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In this paper, the stable Au complexes are classified according to the coordination atoms and their characteristic structure. The recent development of the researches on the antitumor activity of Au complexes including the structure-activity relationship, biological targets and the mechanisms of action are reviewed. The structure of the coordination ligand and the leaving group have great impact on the in vitro cytotoxicity of the Au complex. Many physical and biological methods are introduced to study the interaction between the Au complexes and the suspected bio-target, such as DNA, protein, mitochondrion, thio-containing biomolecules, etc. The interaction modes (intercalating, electrostatic interaction, covalent bonding, etc.) are focused to illustrate the reason for the antitumor activity of Au complexes.

本文按配位原子的不同总结了稳定三价金配合物的结构特征,按其生物活性的构效关系、生物靶点和作用机制综述了三价金配合物抗肿瘤活性研究的最新成果:配体的结构特点以及离去基团对三价金配合物的体外细胞毒性影响较大;介绍了用于检测三价金配合物与可能的生物靶分子之间的相互作用的多种物理和生物学方法,重点关注了相互作用的模式,如嵌入/静电吸引/共价结合等,并解释了三价金配合物抗肿瘤活性的原因。

In this paper, the stable Au complexes are classified according to the coordination atoms and their structural characteristics. The recent development of the researches on the antitumor activity of Au complexes including the structure-activity relationships, biological targets and the mechanisms of action are reviewed. The structure of the coordination ligand and the leaving group have great impact on the in vitro cytotoxicity of the Au complex. Many physical and biological methods are introduced to study the interaction between the Au complexe and the suspected bio-target, such as DNA, protein, mitochondrion, thio-containing biomolecules, etc. The interaction modes (intercalating, electrostatic interaction, covalent bonding, etc.) are focused to illustrate the reason for the antitumor activity of Au complexes.

本文按配位原子的不同总结了稳定三价金配合物的结构特征,按其生物活性的构效关系、生物靶点和作用机制综述了三价金配合物抗肿瘤活性研究的最新成果:配体的结构特点以及离去基团对三价金配合物的体外细胞毒性影响较大;介绍了用于检测三价金配合物与可能的生物靶分子之间相互作用的多种物理和生物学方法,重点关注了相互作用的模式,如嵌入/静电吸引/共价结合等,并解释了三价金配合物抗肿瘤活性的原因。

The journal publishes original research articles, reviews, editorials, commentaries, case reports and letters to the editor, on all branches of medicine and dentistry including basic sciences (anatomy, biochemistry, physiology, pharmacology, psychology, etc) and clinical sciences (internal medicine, surgery, obstetrics and gynaecology, dental surgery, child health, laboratory sciences, radiology, community medicine, etc), as well as the intermediating and background social factors influencing health in developing countries.

杂志刊载原始研究文章,评论,社论,评注,病例报告和写给编辑的信,内容涉及医学和牙科的所有分支,包括基础科学(解剖学,生物化学,生理学,药理学,心理学等),和临床科学(内科医学,外科,产科学和妇产科学,牙外科,儿童健康,实验室科学,放射学,社区医药等),以及影响发展中国家健康的中间和背景社会因子。

The life-relatedness of poems of the early Tang Dynasty is seen in theexpression of the rise-and-fall theme of Urban Poems, the pursuit of individual valueof one's life of the Frontier Poets and Chivalry Poets, and the hope placed on lifeconsciousness in the intoning poems and peacefulness of life of the landscape poems,etc. In addition, it can also be seen in the expression of emotions and ambitions in aparticular image, the pursuit of and the persistence in integrity on the part of the poets,and in the choice and application of the different poetic forms like the Hepta-cantusand the sao style, etc.

初唐诗歌生命化现象普遍存在于都市诗对盛衰主题的表现、边塞诗和咏侠诗对诗人个体生命价值的追求、咏物诗对生命意识的寄寓和山水诗对生命的安顿等方面;此外,还体现在特定意象对情志的抒发,诗人对&风骨&的自觉追求和坚持,对诗歌形式诸如七言歌行、骚体诗等的有意识的选择和运用。

The counsel for the defence had spoken tolerably well, in that provincial tongue which has long constituted the eloquence of the bar, which was formerly employed by all advocates, at Paris as well as at Romorantin or at Montbrison, which to-day, having become classic, is no longer spoken except by the official orators of magistracy, to whom it is suited on account of its grave sonorousness its majestic stride; a tongue in which a husband is called a consort, a woman a spouse; Paris, the centre of art civilization; the king, the monarch; Monseigneur the Bishop, a sainted pontiff; the district-attorney, the eloquent interpreter of public prosecution; the arguments, the accents which we have my.ssbbww.com listened to; the age of Louis XIV., the grand age; a theatre, the temple of Melpomene; the reigning family, the august blood of our kings; a concert, a musical solemnity; the General Commandant of the province, the illustrious warrior, who, etc.; the pupils in the seminary, these tender levities; errors imputed to newspapers, the imposture which distills its venom through the columns of those organs; etc.

那个辩护士谈得相当好,他那种外省的语句,从前无论在巴黎也好,在罗莫朗坦或蒙勃里松也好,凡是律师都习惯采用,早已成为律师们的词藻,但今天这种语句已成古典的了,它那种持重的声调、庄严的气派,正适合公堂上的那些公家发言人,所以8ttt8现在 dd dtt。 com 只有他们还偶然用用;譬如称丈夫为&良人&,妻子为&内助&,巴黎为&艺术和文化的中心&,国王为&元首&,主教先生为&元圣&,检察官为&辩才无碍的锄奸大士&,律师的辩词称&刚才洗耳恭听过的高论&,路易十四的世纪为&大世纪&,剧场为&墨尔波墨涅殿&,在朝的王室为&我先王的圣血&,音乐会为&雍和大典&,统辖一省的将军为&驰名的壮士某&,教士培养所里的小徒弟为&娇僧&,责令某报该负责的错误为&在刊物篇幅中散布毒素的花言巧语&等等。

The contents of this Act include:General Provisions;The Application for Registration and the Processing thereof;Period of Validity of the Design Registration;Licencing,Assignment,etc.;Termination of the Registration,etc.;Duty of Disclosure and so on.

其内容包括:注册的申请及其处理;外观设计注册的有效期;许可,转让等;注册终止等;披露责任等等。

Because of those animails and the effect of aurelias,jellyfishes they ate,they may kill me as well,they used niddles to harm my eye and many other parts of my body,gave poisonous drugs,cockroaches,centipedes,mantises etc for me to eat while I am sleeping,all the harm they've done to me is etc.

由于这些动物和他们吃的水母,海蜇等等的影响,他们也可能杀了我,他们也用针在我晚上睡觉时候扎我的眼睛等等很多部位,给我吃毒药,蟑螂,蜈蚣,螳螂等等,所作所为也是等等。

Because of those animails and the effect of aurelias,jellyfishes they ate,they may kill me as well,they used niddles to harm my eye and many other parts of my body,gave poisonous drugs,cockroaches,centipedes,mantises etc for me to eat while I am sleeping,all the harm they've done to me is etc.

由于这些动物和他们吃的水母,海蜇等等的影响,他们也可能杀了我,他们也用针在我晚上睡安达窃听觉时候扎我的眼睛等等很多部位,给我吃毒药,蟑螂,蜈蚣,螳螂等等,所作所为也是等等。

Because of those animails and the effect of aurelias,jellyfishes they ate,they may kill me as well,they used niddles to harm my eye and many other parts of my body,gave poisonous drugs,cockroaches,centipedes,mantises etc for me to eat while I am sleeping,all the harm they've done to me is etc.

由于这些动物和他们吃的水母,海蜇等等的影响,他们也可能杀了我,他们也用针在我晚上睡焦作窃听觉时候扎我的眼睛等等很多部位,给我吃毒药,蟑螂,蜈蚣,螳螂等等,所作所为也是等等。

An infinitive can be the complement of be able to, begin, and like, etc, and it takes no prefixes except ka-. A nominalized verb can be the complement of see, and know, etc.

动词不定式在做为'能','开始','喜欢'等动词的补语时不接任何前缀,而名物化前缀则可以接趋向前缀表完成体,这构成两者最大的不同。

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推荐网络例句

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气,收缩臀部肌肉;拱起身体,尽量抬起头来,右腿伸直朝向天花板(膝微屈,以避免肌肉紧张)。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化,但却比去年同期高8%。

However, to get a true quote, you will need to provide detailed personal and financial information.

然而,要让一个真正的引用,你需要提供详细的个人和财务信息。