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Hydrosalpinx is detrimental to the outcome of IVF-ET and may cause the increase of abortion,appropriate procedure should be adopted to deal with the problem before the IVF-ET and may improve the outcome of IVF-ET and may decrease the abortion rate.Compared with the salpingectomy,the proximal tubal ligation with distal tubal salingostomy may be a better option in this situation and it may cause less interference to the ovarian function.

输卵管积水对IVF-ET有不良影响，增加了流产率及异位妊娠率，在IVF-ET前对输卵管积水进行适当的处理有助于提高临床妊娠率，降低流产率；与输卵管切除术相比，输卵管近端结扎伞端造口术对卵巢功能影响较小，不增加流产率及异位妊娠率。

By superfusion of ET-1,the hypoxia-induced decrease in RPF was remarkably potentiated and the occurrence of pacemaker arrest was shifted to an earlier time. The h3,poxia-induced effects could be effectively attenuated after pretreatment with BQ-123,implying the role of endogenous ET-1 release in hypoxia-induced effects.

ET-1可显著加重缺氧所致的RPF降低，使起搏细胞停跳时间前移；而以ET*受体阻断剂BQ-123预处理窦房结标本后，则能有效地缓解缺氧对起搏细胞的效应，提示内源性ET-1的释放在缺氧效应中的作用。

Methods: Five 10-23 deoxyribozymes (DZ1-DZ5) with 2 phosphorothioate groups at 5' and 3' end were designed and synthesized. Full sequence ET-1 RNA was transcripted and FAM-labeled 10-23 deoxyribozyme was used to select cleavable 10-23 deoxyribozyme in vitro and to detect intracellular uptake. The content of ET-1 mRNA was measured by semi-quantitative RT-PCR after 10-23 deoxyribozyme was transfected into cultured neonatal rat cardiomyocytes.

体外转录ET-1全长RNA底物，设计并合成5条ET-1 10-23脱氧核酶(DZ1~DZ5)，其5'及3'端各有2个核苷酸硫代修饰，体外切割ET-1RNA底物，筛选有效脱氧核酶；5'标记荧光素FAM的10-23脱氧核酶瞬间转染新生大鼠心肌细胞以观察对10-23脱氧核酶的摄取；采用半定量RT-PCR检测ET-1基因的表达。

Cato says, the master of a family must have in his rustic villa "cellam oleariam, vinariam, dolia multa, uti lubeat caritatem expectare, et rei, et virtuti, et gloriae erit," that is,"an oil and wine cellar, many casks, so that it may be pleasant to expect hard times; it will be for his advantage, and virtue, and glory."

卡托说，一个家庭的主人（patr emfa-milias）必须在他的乡居别墅中，具有&cellam oleariam，vinariam ，dolia m ulta，uti lubeat caritatem expectare，etrei，et virtuti，et gloriae erit，&也就是说，&一个放油放酒的地窖，放进许多桶去预防艰难的日子，这是于他有利的，有价值的，光荣的。&

There are four kind of isoforms of endothelin in human and other mammals named ET-1, ET-2, ET-3 and ET-β, which are slightly different in construction and pharmacological effect. In human beings, ET-1 is the dominative subtypes. ET-1 remains in blood at a low level about 5ng per liter on physical state. It is synthesized, stored, released and metabolized locally. The half-life of ET-1 is about 1 hour. ET-1 is the most potent vasoconstrictive factor till now, and it is more functional in vein than in artery. In vascular bed, there are two kind of ET receptors. Type A mainly located in smooth muscle cells, whereas type B in endothelial cells. The latter can stimulate intimal hyperplasia via a parasecretion way and activate some oncogenes such as c-fos and c-myc and then enhance their expression. These alterations result in constriction of blood vessels, thus the SMC steps into proliferate state from silent state.

人及哺乳动物体内有四种结构及药理学性质略有差异的异物体，分别为ET-1、ET-2、ET-3、ET-β，而在人主要是ET-1，在生理条件下，ET-1在血浆中含量较低，约为5ng〓，故ET-1不是一个循环激素，而是局部合成释放，局部起作用的活性物质，半衰期约1小时，ET-1是目前已知的最强的血管收缩剂，对静脉的作用比动脉强，在血管床，ET受体有A、B两型，A型主要分布在平滑肌细胞，B型主要分布在内皮细胞，它可以通过旁分泌途径刺激内膜增生，具有有丝分裂原效应，可以激活某些癌基因如C-fos、C-myc使其表达增强引起血管收缩，使静止期SMC进入增殖期，还可以通过信号传导途径，与bFGF、GTF-β、PDGF等生长因子协同作用，起共有丝分裂原作用。

Objetive:To investigate the histopathological features and detect the mutation of JAK2V617F in PV、ET and IMF;to analyze the effects of the stages of myelofibrosis and the mutation on the number of leucocyte in PV and ET patients;Methods: the morphological features of 69 patients who dignosed in the first time were studied by HGF and Gomori stains ; the mutation of JAK2V617F was detected in 38 blood or marrow samples of PV、ET and IMF patients by real-time PCR;the effects of the stages of myelofibrosis and the mutation on leucocytes were analyzed;Results: Different stages of reticulin were observed in 15 PV and 15 ET patiens'marrow sections,and the cytosis、the pleomorphism and the bone trabecula side location of megakaryocytes were observed in all PV、ET and IMF patients;the means of leucocyte in patients with and without JAK2V617F were 20.4×109/Land 11.4×109/L respectively;the P value was 0.367 as comparing the leucocytes among different stages of reticulin increasing.

目的：探讨PV、ET、IMF患者的骨髓病理特点并且检测JAK2V617F突变的发生率，分析骨髓中纤维增生程度以及JAK2V617F对PV、ET患者白细胞数的影响；方法：69例初诊患者的骨髓切片经HGF染色以及Gomori染色后进行形态学研究；并利用real-time PCR法测38例患者的骨髓或者外周血的JAK2V617F突变；分析骨髓切片中纤维组织增生程度以及JAK2突变对患者白细胞数的影响；结果：15例PV和15例ET患者的骨髓切片中可以观察到不同程度的纤维组织增生，所有PV、ET、IMF患者骨髓病理中可见到巨核细胞增多、巨核细胞多形性改变以及巨核细胞定位于骨小梁旁；12例PV、4例ET、4例IMF中检测到JAK2V617F；有突变和无突变患者发病时白细胞数均值分别为20.4×109/L和11.4×109/L，比较不同纤维增生程度的PV、ET患者的白细胞数均值，P值为0.367。

The results were as follows: ET〓-RNA expression levels in hypothalamus, hippocampus and temporoparietal grey and white matters of the low and high speed injury groups were elevated significantly than that of control group (p＜0.05), but in the above areas of brain, ET〓-RNA expression in hypothalamus and hippocampus were the highest (p＜0.01), especially in the high speed injury group; ET〓 contents in hypothalamus and hippocampus in the two injury groups, especially in the high speed injury group, increased very significantly than that of control group (p＜ 0.01); ET〓 contents in CSF and plasma in the two injury groups, also especially in high speed injury group, increased markedly after 2 hours, and lasted for 8 hours after injury; ET〓 contents in the abovt areas of brain were of highly positive correlation with that in plasma or in CSF.

实验显示：致伤犬伤后海马、丘脑下部、颞顶叶灰、白质内皮素—1RNA表达较对照组显著增强（p＜0.01，p＜0.05），其中以海马和丘脑下部最显著（p＜0.01），高速组最明显（p＜0.01）；海马和丘脑下部ET〓含量较对照组显著升高（p＜0.01）；血浆、CSF中ET〓含量在伤后2h即极显著升高（p＜0.01），并持续至伤后8h，上述各组均以高速组最为显著（p＜0.01）；各脑区和血浆，CSF中ET〓含量间呈显著正相关。

The crystallization behavior of polyethylene terephthalate ; random poly (ethylene/tetramethylene terephthalate) P (ET/BT ; poly (ethylene terephthalate/ isophthalate) P (ET/EI and poly (ethylene terephthalate/adipate) P (ET/EA copolyesters; and block polyethylene terephthalate/polyethylene glycol and polyethylene terephthalate/polytetramethylene glycol were studied by DLI ; DSC; WAXD; PLM and IR technique.

本文通过缩聚反应合成了不同分子量的聚对苯二甲酸乙二酯；聚对苯二甲酸酯P(ET／BT、聚（对苯二甲酸／间苯二甲酸）乙二醇酯P(ET／EI和聚乙二醇酯P(ET／EA等系列的无规共聚酯以及PET／PBG和PET／PEG等系列的嵌段共聚酯，并采用DLI、DSC、WAXD、IR和NMR等实验技术着重研究了它们的结晶行为与共聚酯的序列结构。

The crystallization behavior of polyethylene terephthalate ; random poly (ethylene/tetramethylene terephthalate) P (ET/BT ; poly (ethylene terephthalate/ isophthalate) P (ET/EI and poly (ethylene terephthalate/adipate) P (ET/EA copolyesters; and block polyethylene terephthalate/polyethylene glycol and polyethylene terephthalate/polytetramethylene glycol were studied by DLI ; DSC; WAXD; PLM and IR technique.

中文题名PET及其共聚酯的结晶行为副题名外文题名 The crystallization behavior of PET and its copolyesters 论文作者边界导师封麟先叶胜荣教授学科专业高分子化学与物理研究领域\研究方向学位级别博士学位授予单位浙江大学学位授予日期2001 论文页码总数10，159页关键词聚对苯甲酸乙二酯聚酯结晶馆藏号BSLW /2003 /O633 /1 本文通过缩聚反应合成了不同分子量的聚对苯二甲酸乙二酯；聚对苯二甲酸酯P(ET／BT、聚（对苯二甲酸／间苯二甲酸）乙二醇酯P(ET／EI和聚乙二醇酯P(ET／EA等系列的无规共聚酯以及PET／PBG和PET／PEG等系列的嵌段共聚酯，并采用DLI、DSC、WAXD、IR和NMR等实验技术着重研究了它们的结晶行为与共聚酯的序列结构。

RESULTS:(1) ET-1 could increase total protein production, surface area, ERKs activity and ［Ca2+］i in cultured cardiomyocyte in dose-dependent manner at concentrations ranging from 10-9 to 10-7 mol/L. And this effect could be abolished by BQ123, an antagonist of ETA receptor, partly inhibited by PTX, but not by BQ788, an antagonist of ETB receptor.（2）The activation of ERKs and the increase of ［Ca2+］i induced by ET-1 were obviously inhibited by PD98059, a selective ERKs kinase inhibitor, and nifedipine, a calcium channel blocker, respectively. Both antagonists partially inhibited ET-1-stimulated cardiomyocyte hypertrophic response.(3) Staurosporine, a selective PKC inhibitor, could inhibit ET-1-stimulated cardiomyocyte hypertrophic response and increase of ［Ca2+］i, but not affect the activation of ERKs.

结果： ①ET-1浓度依赖性增加新生大鼠心肌细胞蛋白质含量和心肌细胞表面积、ERKs活性及［Ca2+］i浓度，以上作用可被ETA受体拮抗剂BQ123所完全抑制，被百日咳毒素部分抑制，而ETB受体拮抗剂BQ788则无效；②ERKs激酶特异性抑制剂PD98059可完全抑制ET-1激活ERKs的作用，钙通道拮抗剂硝苯地平可明显抑制ET-1介导的［Ca2+］i浓度增加，但二者皆仅部分抑制ET-1介导的心肌细胞肥大反应；③蛋白激酶C选择性抑制剂staurosporine并不能明显抑制ET-1介导的ERKs激活，但可抑制ET-1介导的的［Ca2+］i浓度增加及心肌细胞肥大反应。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。