查询词典 erythroid

The experiment confirmed the important role of SOCS-3 in erythropoietic development and provided a useful new way for production of erythroid lineage cells.

研究结果证明，SOCS-3在造血发育中有重要调控作用，而对其表达进行干涉或沉默将在规模化的红细胞诱导研究中发挥重要作用。

In the biological functionaddition, both biochanin A and hesperitin might inhibited the colony -formation forming ability of K562 cells through up-regulated Notch signaling. Besides,The treatment with biochanin A and hesperitin enhanced the erythroid-differentiation of K562 cells. It is important to investigate Tthe molecular mechanisms of biochanin A and hesperitin to regulate the endogenous CBF1-dependent Notch signaling will be further investigated.

在生物功能方面，biochanin A与hesperitin可能经由Notch讯息传导的活化，抑制了K562细胞群落的形成，除此之外，这两种药物均明显促进K562细胞往红血球分化。biochanin A与hesperitin对於CBF1所媒介之内生性Notch讯息传导的分子调控机制仍有许多问题尚未厘清，需要更多的实验与研究来讨论。

We aim to screen and identify the key potential trans-factors during hemoglobin switch. We firstly analyzed differential expression of mRNAs in erythroid induction cultures of CD34+ cells derived from normal umbilical cord blood, adult bone marrow, and bone marrow of a heterocellular hereditary persistence of fetal hemoglobin patient. We identified ZF (HCF-binding transcription factor, Zhangfei) and SH3GLB1(SH3-domain GRB2-like endophilin B1) that had differential expression in the above three cultures. Furthermore, we confirmed the different expression of the above two genes by quantitative real-time PCR.

为鉴别影响珠蛋白基因表达和开关的新的重要调节因子，我们首先分析了人脐带血、正常成人骨髓和异细胞型胎儿血红蛋白持续存在综合症患者骨髓细胞红系诱导培养物中基因表达的差异，发现ZF(HCF-binding transcription factor，Zhangfei)和SH3GLB1（SH3-domain GRB2-like endophilin B1）在这三种不同来源的红细胞内具有显著的表达差异，并通过实时定量PCR方法验证了差异的真实性。

In this study, Mono-nuclear cells containing hematopoietic stem/progenitor cells were isolated from umbilical cord blood of normal full-term deliveries, healthy adult and heterocellular HPFH patient bone marrow by density gradient centrifugation. After simple purification and expansion in vitro, MNCs were induced to erythroid cell differentiation using different culture systems and cytokines including Epo, IL-3 and GM-CSF.

本研究首先利用密度梯度离心方法，从正常成人和异细胞型遗传性胎儿血红蛋白持续存在综合症家系患者的骨髓组织、健康足月正常分娩胎儿脐带血中分离得到了含有造血干／祖细胞的单个核细胞(Mono-Nuclear Cell，MNC)，进行初步纯化及体外扩增后，组合使用Epo、IL-3、GM-CSF等细胞因子，将造血干／祖细胞向红系方向进行诱导培养。

EPO was considered to be excreted only by the kidney and responsible for the proliferation,maturation,and differentiation of the precursors of the erythroid cell line incretory hormone.

EPO以往一直被认为仅在肾脏分泌，是一种作用于骨髓造血细胞，促进红系祖细胞增生、分化、最终成熟的内分泌激素。

EPO was considered to be excreted only by the kidney and responsible for the proliferation, maturation, and differentiation of the precursors of the erythroid cell line incretory hormone.

在大鼠脑损伤模型中，EPO对抗损伤后炎症反应，并起到神经保护作用；在实验性自身免疫性脑脊髓炎大鼠模型和大鼠大脑中动脉梗塞模型的研究中发现，EPO可明显抑制促炎性细胞因子和趋化因子的产生，进而减轻炎症反应。

Most importantly, we show that corrected Fanconi-anaemia-specific iPS cells can give rise to haematopoietic progenitors of the myeloid and erythroid lineages that are phenotypically normal, that is, disease-free.

血液疾病有可能成为基因修正疗法的第一目标，因为这些修正细胞可经骨髓移植很容易地植回患者体内。但在利用iPS源性细胞进行任何临床试验前都必须解决一些严重相关的问题，其中最重要的就是致癌问题。

Beta-thalassemia major is a serious hereditary hemolytic anemia which does great harm to human being.It is a monogenic disease characterised by a reduced synthesis of beta-globin chains,which dues to the Doint mutation or deletion of beta-globin gene and its control region.It not only decreases the hemoglobin level,but breaks the balance of alpha/beta synthesis ratio.The major cellular pathogenetic mechanisms in beta thalassemia are based primarily on the deleterious effects produced by the accumulation of the excess alpha globin chain.These excess alpha-globin chains cannot form stable tetrameric structure and deposit in erythroid cells.They cause large ineffective erythropoiesis on their own,accelerate red cells destruction,and lead to hemolysis.

地中海贫血是一种对人类健康危害严重的遗传性溶血性贫血病，是因β-珠蛋白基因及其调控序列的点突变或缺失致使β-珠蛋白肽链合成减少或完全停止，这不仅使患者血红蛋白水平降低，而且使原来在数量上与之持平的α-珠蛋白肽链相对过剩，这些相对过剩的游离α-珠蛋白肽链并不能形成稳定的四聚体，它们沉积在红细胞中导致了大量无效红细胞生成和红细胞寿命缩短，引起了严重的溶血性贫血。

To get more informationon gene regulation during erythroid differentiation of K562 cells, we applied modifieddifferential display reverse transcription polymerase chain reaction methodto identify genes showing differential expression in uninduced and hemin-induced K562cells.

为进一步获得分化过程中相关基因表达的信息，我们应用改良的差异显示RT-PCR技术，分析K562细胞在Hemin诱导的红系分化前后的基因表达变化，共获得357条差异表达带。

Note the presence of megakaryocytes, erythroid islands, and granulocytic precursors This marrow is taken from the posterior iliac crest in a middle aged person, so it is about 50% cellular, with steatocytes admixed with the marrow elements.

可见巨核细胞、红细胞岛和粒细胞前体细胞。这是从一中年人的后髂嵴中取出来的骨髓，故约50%是细胞，并和骨髓成分混在一起。

In the negative and interrogative forms, of course, this is identical to the non-emphatic forms.

。但是，在否定句或疑问句里，这种带有"do"的方法表达的效果却没有什么强调的意思。

Go down on one's knees;kneel down

屈膝跪下。。。下跪祈祷