查询词典 erythroid

The aim of this study was to investigate the curative effects of amifostine combined with recombinant human β-erythropoietin on patients with pure erythroid aplasia.

本研究旨在观察氨磷汀联合重组人β红系生成素对单纯红系再生障碍性贫血患者的近期疗效及副作用。

Pure red cell aplasia is a haematological syndrome characterize by profound anemia and absence of erythroid precursors in the bone marrow.

纯粹红血球发育不全为血液学之症候群，其特徵为严重贫血，骨髓中缺少红血球前导细胞。

The precipitates of alpha-globin chains in major beta-thalassemia erythroid cells were lessened after treatment with ASON,particularly in early erythroblast stage.There were no changes in those of control group.

此外，透射电镜结果也证实ASON组中红系细胞内过剩α-珠蛋白肽链沉积有所减少，特别是在早期幼红细胞中；在空白对照组中沉积物无任何变化。

On the basis of observation on the denucleation process of mammalian erythroid cells in vito and in vitro, the present study was designed to investigate the regulatory effect and its mechanism of mammalian erythroblast cytoplasmic factor on malignant phenotype and gene expression of hybrid cells formed by cellular engineering fechnique of cell hybridization between the mouse plasmocytomas SP (2/0) cell line and rat erythroblasts.

本研究选用正常大鼠中幼、晚幼成红细胞与小鼠浆细胞瘤（SP2/0）细胞进行异种细胞杂交，研究哺乳动物红细胞胞质因子对肿瘤细胞恶性调控的效应及其机制。

We found that NaBu stimulated ALAS2 gene expression not only in erythroid K562 cells, but also in non-erythroid 293T cells with a concurrent increase in acetylation level of histone H3 and dimethylation level of K4 at the same histone at ALAS2 gene promoter.

同时ALAS2基因启动子的组蛋白H3乙酰化水平以及组蛋白H3的第4位赖氨酸的双甲基化水平升高。

objective effects of plant tannins,chebulinic acid and tellimagrandin i on chemically induced hemoglobin synthesis in k562 cells were investigated.methods the hemoglobin synthesis situation was assayed with benzidine staining.erythroid antigens glycophorin a expression on the surface of k562 cells was labeled by direct immunofluorescence using fluorescein isothiocyanate-conjugated anti-gpa antibodies.then flow cytometric analysis was performed to detect gpa expression levels on surface of the cells.results both chebulinic acid and tellimagrandin i could inhibit the hemoglobin synthesis of butyric acid and hemin-treated k562 cells in a concentration-dependant manner.however,the ba-induced k562 cells were more sensitive to two tannins than heroin-induced cells.conclusion chebulinic acid and tellimagrandin i have inhibitory effect on the erythroid differentiation.

目的 研究可水解单宁诃子酸和特里马素i对氯化高铁血红素和丁酸钠诱导k562细胞红系分化的影响。方法四甲基偶氮噻唑蓝法分析诃子酸和特里马素i对k562细胞生长的影响，联苯胺染色法检测血红蛋白合成情况，应用免疫荧光和流式细胞术检测血型糖蛋白a在细胞表面的表达。结果诃子酸和特里马素i在0.04～0.09？mmol／l浓度下均可显著抑制k562细胞的生长增殖。2种单宁化合物(0.002～0.01？mmol／l)可显著抑制丁酸钠诱导的k562细胞血红蛋白合成，2种单宁化合物(0.01～0.05？mmol／l)还可显著抑制氯化高铁血红素诱导的血红蛋白合成，特里马素i(0.01？mmol／l)还抑制丁酸钠诱导的gpa在细胞表面表达。结论诃子酸和特里马素i对红系分化有抑制作用。

One of its roles is to change the BFU-E(burst-forming unit-erythroid) cells, which are the earliest erythrocyte precursors in the erythrocytic series, into the CFU-E (colony-forming unit-erythroid).

其中一个重要作用是使BFU-E（爆式红细胞集落形成单元）细胞（在红细胞系中是一种早期前驱红细胞）向CFU-E细胞转变。

Objective To explore the cell growth and the expression of erythroid hematopoesis associated gene during erythroid differentiation.

目的 探讨红系细胞分化中细胞生长及相关转录因子表达的变化。

Healthy kunming mice mate to produce embryo. sacifice prognant mice at 14dpc, make preparation of fetal liver and born marrow. then proceed 40%-70% percoll gradient seperation to obtain nucleated erythroid cells. resuspend the purified erythroid cells in DMEM medium without serum, adjust cell concentration to 5×10〓.

正常健康昆明小鼠交配，待胚胎发育至14天时，处死怀孕母鼠，取胎鼠肝脏，用另一组成年小鼠制备骨髓；然后应用40％-70％Percoll梯度分离法分离胎肝和骨髓中的有核红细胞，纯化后的细胞用无血清DMEM培养基悬浮，调整细胞浓度为5×〓／ml。

Meanwhile,HDAC1 acetylation level is significantly increased.The overexpression of HDAC1 can promote erythroid cell proliferation and inhibits induced differentiation,the knockdown of HDAC1 or 2 inhibits erythroid cell proliferation and promotes induced differentiation.We also found that HDAC1 affects GATA1 mediated transcription activity.Thus our data revealed that HDAC1 may negatively regulate GATA1 mediated transcription and suggest that the dynamic regulation of GATA1 associated NuRD/MeCP1/HDAC1/HDAC2 complex may determine the onset of erythroid differentiation programs.Moreover,this study will eventually help to design new therapeutic approaches in treatment of leukemia.

研究发现在被诱导分化的小鼠红细胞白血病细胞中与GATA1相结合的HDAC1被乙酰化并失去活性，在血细胞中过表达HDAC1能够促进血细胞的增殖并抑制分化，反之在血细胞中敲除HDAC1或HDAC2能抑制血红细胞的增殖并促进分化，而且HDAC1能够负调控GATA1的转录活性，GATA1与NuRD/MeCP1复合体之间的动态调控，决定血红细胞分化的发生和发展，并为探索白血病的致病机理奠定了理论基础。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失