查询词典 erk

Cell of the HT-29 after result EGCG is handled grows to be restrained apparently, present wither of cell of;HT-29 of dependence of time, dosage to die the phosphation level expression that leads elevatory;EGFR and ERK is reduced.

结果EGCG处理后HT-29细胞生长明显抑制，呈现时间、剂量依靠性；HT-29细胞凋亡率升高；EGFR和ERK的磷酸化水平表达下调。

However,there was no significant difference between the stimulated and unstimulated groups with regard to the phosphorylation of ERK.

与无电刺激组相比，电刺激组OLETF大鼠骨骼肌细胞Akt、AMPK蛋白活性明显增加(P＜0.01)；而ERK蛋白活性无明显改变(P＞0.05)。

Therefore, it is important to ask whether both Oct-2 and NF-κB participate the MEK/ERK dependent G-CSF expression. G-CSFp-(-289~+25)-Luc, CSF-box-deleted G-CSFp-(-145~+25)-Luc, or octamer-mutated Oct-mut-G-CSFp-(-289~+25)-Luc reporter plasmids were used to investigate the importance of CSF-box and octamer in response to LPS.

在G-CSF的启动子上有两段已被发现对其活性相当重要的序列：CSF-box及octamer，根据过去研究及本实验室未发表的实验结果，此两段序列分别由NF-κB以及Oct-2所结合；於是我们推测MEK/ERK讯息传递路径的下游可能透过NF-κB及Oct-2来调控G-CSF表现。

In this study, we investigate further the mechanism as to how glucose activates Erk-1/2 and p70S6K.

在这篇文章中，我们进一步研究了关于葡萄糖如何活化Erk-1/2和p70S6K的机制。

Its absence perturbs the balance between actiation of the JAK–STAT and SHP-2–ERK-1/2–MAPK pathways, resulting in less self-renewal and a greater potential for differentiation into the primitie endoderm lineage.

SOCS-3的缺乏破坏了激活JAK–STAT和SHP-2–ERK-1/2–MAPK信号转导通路之间的平衡，这就导致了较少的自我更新，而是较强的分化成原始内胚层谱系的潜能。

Its absence perturbs the balance between actiation of the JAK-STAT and SHP-2-ERK-1/2-MAPK pathways, resulting in less self-renewal and a greater potential for differentiation into the primitie endoderm lineage.

它的缺乏干扰了JAK-STAT和SHP-2-ERK-1/2-MAPK 通路之间的平衡，最终导致自我更新能力减弱和更易于向原始内胚层分化。

Increasing cAMP levels by GLP-1 potentiated glucose-induced Erk-1/2 phosphorylation via PKA activation.

由GLP-1增加的cAMP 水平经过PKA活化加强了葡萄糖诱导的Erk-1/2 磷酸化。

These results suggest that morphine withdrawal selectively impairs the cued fear extinction through inhibiting the ERK phosphorylation in the amygdale and mPFC. Histamine deficiency not only enhances acquisition the cued and contextual fear conditioning and but also potentiates the impairment of extinction of cued fear memory.

这些结果提示：吗啡戒断能选择性抑制恐惧记忆的消除，此作用是通过抑制杏仁核和mPFC脑区内ERK蛋白磷酸化来实现的；组胺缺乏能增强线索和背景恐惧记忆的获得以及增强吗啡戒断对线索恐惧记忆消除的抑制作用。

In vivo, CXCR4-A549 and A549 cells were injected subcutaneously into nude mice(each group in 6).Four weeks later the mice were scarified and the tumors in situ and the lungs were taken out to be examined histologically.(3) Th cell cycle distribution was measured by flow cytometry to analyse the effect of SDF-1/CXCR4 in the cell proliferation and atoposis. The changes of the intracellular calcium concentration after SDF-1 activation were aslo measured by flow cytometry. Western blot was used to anlayse the phosphorylation of AKT and ERK, and the expression of MMP-2 and VEGF-C.

3为探讨SDF-1/CXCR4在肺癌侵袭和转移中的作用机制：①利用流式细胞仪检测CXCR4-A549与A549两组细胞的增殖和凋亡，分析上调CXCR4的表达后，对细胞生长周期的影响；②利用流式细胞仪检测两组细胞钙离子内流强度，分析SDF-1/CXCR4对钙离子通道活性的调控；③采用Western blot实验检测两组细胞PI3K/AKT、MAPK/ERK相关信号通路的活性，分析SDF-1/CXCR4可能激活的下游信号分子；④采用Western blot和RT-PCR检测两组细胞肿瘤转移相关基因VEGF-C、MMP-2的表达，探讨SDF-1/CXCR4与VEGF-C、MMP-2的相互作用关系。

To explore the reciprocal effects of host-tumor interaction, we developed a system to assess the gene expression patterns and the diversity of gene expression of ERK and PI3K pathway in CAOV3 human ovarian cancer cells and primary carcinoma-associated fibroblasts cocultured with each other for 48 hours with RT-PCR.

方法1。采用逆转录聚合酶链反应的方法分别检测交互作用48小时后的卵巢癌相关成纤维细胞与卵巢癌细胞中基因表达的改变，CAFs及CAOV3细胞外信号调节激酶通路的ERK，PI3K基因表达的变化；2。

Plunder melds and run with this jewel!

掠夺melds和运行与此宝石！

My dream is to be a crazy growing tree and extend at the edge between the city and the forest.

此刻，也许正是在通往天国的路上，我体验着这白色的晕旋。