查询词典 erk

OBJECTIVE: To investigate the role of ERK activation in establishment and maintenance of chronic neuropathic pain.

目的：研究ERK在慢性压迫性损伤引起的神经痛形成和维持中的作用。

The objective of the present study is to explore the effect of inhibition of ERK on arsenic trioxide - induced apoptosis in gastric cancer cell line.

本研究的目的是通过检测抑制ERK对As_2O_3诱导的胃癌细胞凋亡有无影响，探讨ERK在As_2O_3诱导胃癌细胞凋亡的信号转导途径中的作用。

It is concluded that the inhibition of ERK may be involved in sodium butyrate inducing differentiation in SKM-1 cells.

ERK通路抑制是丁酸钠诱导SKM-1细胞分化的重要分子机制。

These results indicate that the ERK pathway may participate in the molecular mechanism of depression.

这些结果提示ERK信号通路可能参与了抑郁行为的调节，但并不能得出ERK信号通路损伤是导致抑郁行为产生的原因的结论。

Methods: Immunohistochemistry and image analysis techniques are applied to examine the phosphorylated extracellular signal－regulated kinase in epidermis of non－expanded skin and expanded skin. Results:Phosphorylated ERK expressed in basal cell layer of epiderm including non－expanded skin and expanded skin are expressed. But in expanded skin they are expressed significantly and densely compared to non－expanded skin. There are significant difference in relative to location of expanded skin and regions of expanded skin.

结果： 1扩张皮肤和正常皮肤表皮基底层都有磷酸化ERK 的表达和分布，但扩张皮肤中的磷酸化ERK的分布和表达较明显，染色较深且密，部分阳性细胞呈多层排列，有散在的增殖团区；2扩张皮肤的顶部和侧部差别不十分明显，而侧部和顶部与基底部有一定的差别，基底部染色较深，多为细胞核着色；3 经图像分析不同部位的正常皮肤和扩张皮肤以及扩张皮肤的不同部分的相对灰度值和阳性细胞密度，进一步证实了上述观察结果。

The blots were probed with anti-Cdx-2, anti-JNK (Santa Cruz Biotechnology, Santa Cruz, California), anti-ERK, anti-phospho -ERK, antip38MAPK,anti-p-p38MAPK, anti-p-JNK (Cell Signaling, Beverly, Massachusetts) and anti-actin (Amersham Life Sciences,Piscataway, New Jersey) antibodies, and then incubated with appropriate species specific secondary antibodies labeled with horseradish peroxidase.

Blots分别与抗CDX-2抗体，抗JNK抗体（圣克鲁斯生物技术，圣克鲁斯，加州），抗ERK抗体，抗phospho -ERK抗体，抗p38MAPK抗体，抗p-p38MAPK抗体，抗p-JNK抗体（Cell Signaling， Beverly，美国马萨诸塞州）和抗actin抗体（ Amersham生命科学，皮斯卡塔韦，新泽西州）作用，然后在与辣根过氧化物酶标记的第二抗体孵育。

In conclusion , ERK and telomerase serve a function to some extent in drug resistance of leukemia and ovariancarcinoma cells. The inhibition of ERK signal transduction pathways led to reduction of phosphorylated ERK1 and ERK2protein expression level , and successionally down2regulated the telomerase activity.

通过阻抑ERK通路，降低磷酸化ERK1/ 2蛋白表达水平，进而下调端粒酶活性，可以达到增强白血病和卵巢癌耐药细胞对HRT 或DDP 敏感性的目的。

Rats were bilaterally implanted with cannulas in the dHP or mPFC and were microinjected with U0126, a specific inhibitor of ERK upstream activator, or vehicle for 7 consecutive days.

结果表明海马ERK信号通路阻断大鼠表现了抑郁症的核心症状快感缺乏和明显的焦虑行为；前额叶皮质ERK信号通路阻断大鼠表现为快感缺乏和活动水平的降低。

METHODS: The level of intracellular calcium of human microglia grown on coverslip,which was loaded by calcium-probe,Fluo-4,and then treated in various experimental processing,was detected by confocal microscopy with time resolution mode.The binding of gp120 to human microglia was determined with confocal microscopy or flow cytometry after treatment with gp120 and stained with anti-gp120-FITC antibody.Phosphorylation of ERK within human microglia with or without gp120 stimulation was analyzed with confocal microscopy following the direct immuno-staining with anti-phosphorylated ERK antibody.

用钙离子探针Fluo-4标记粘附在盖玻片上的人小胶质细胞，运用共聚焦显微镜以荧光强度为指标实时观察各种条件下的细胞内钙离子水平的变化；用gp120处理并用anti-gp120-FITC进行染色，运用共聚焦显微镜术和流式细胞术分析人小胶质细胞与gp120结合情况；用抗磷酸化ERK 抗体免疫荧光方法进行染色，运用共聚焦显微镜术和流式细胞术进行ERK磷酸化水平分析。

With the increase of age, expression of basal ERK decreased, but phospho-ERK increase in SHR.

随年龄增加，SHR大鼠基础ERK表达量有所减少，但活化水平增加。

Plunder melds and run with this jewel!

掠夺melds和运行与此宝石！

My dream is to be a crazy growing tree and extend at the edge between the city and the forest.

此刻，也许正是在通往天国的路上，我体验着这白色的晕旋。