查询词典 episomes

The cutoff value of E2/E6, used to distinguish the pure episomal form from a mixed form of episomal and integrated HPV16 DNA, was 0.81 in the multiplex real-time PCR test. c） HPV16 existed as episomes in most of the CIN Ⅰ lesions, and 42.9% of them had mixed episomal/integrated HPV16. The integrated form of HPV16 constituted the majority in most of the CIN Ⅱand CIN Ⅲ cases. In squamous cervical carcinomas, the HPV16 was mostly integrated into the host chromosome. d） The rate of HPV16 integration was associated with the degree of cervical lesions and the rate increased with the progression of cervical disease, e） The rate of pure integrated HPV16 in stage Ⅱ and Ⅲ（88%） was higher than that in stage Ⅰ（33.3%）. Conclusions: a） Multiplex real-time PCR is a rapid and sensitive method for detection of the integration state of HPV16 DNA. b） The integration of HPV16 DNA is a very early event in the development of cervical cancer and may act as an activation mechanism for progression from preinvasive to invasive cervical cancer, c） The pure integrated HPV16 in cervical cancer may be a useful prognostic indicator.

HPV—16E2、E6标准曲线相关系数均为1.00，扩增效率均在95％以上：2）确定0，81作为多重实时PCR区分游离型和混合型HPV-16的界值、3）CINⅠ中HPV—16大多以游离方式存在，但仍有整合的发生（42，9％）；CINⅡ和CINⅢ中HPV—16以混合型为主：浸润癌中以整合型HPV—16为主。4）HPV-16整合发生率与不同程度的宫颈病变有关，并且随着宫颈病变级别的升高HPV-16整合发生率呈上升趋势-5）Ⅱ＋Ⅲ期宫颈癌中整合型HPV—16所占比例显著高于Ⅰ期宫颈癌结论：1）多重实时定量PCR是一种敏感性高、简便快速的HPV—16病毒存在状态的检测方法2）HPV-16整合是宫颈癌变的早期事件，与宫颈癌前病变的进展有关。3）宫颈癌中整合型HPV—16的发生可能具有预后价值

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。