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One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活,ICAM-1表达升高,与被激活的PMN表面表达的LFA-1相结合,"PMN-EC"相互作用加剧,一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍;另一方面粘附的PMN过度吞噬或激活,当白细胞吞噬的颗粒不能被封闭隔离,连同细胞内的酶被释放出来,其中的PMN-elastase能够降解细胞基质中各种成分,水解多种蛋白,加重胰腺的毛细血管内皮细胞和腺泡的损伤;释放的溶酶体酶使组织蛋白水解,产生的不饱和脂肪酸引发脂质过氧化方应,破坏细胞膜的结构和功能;释放的炎性细胞因子,激发其他的免疫细胞的功能,导致进一步的组织损伤和坏死,加重SAP的病理损伤,最终导致休克、脓毒血症及多器官功能障碍等严重后果。

The alimentary canal of most animals relies very little on lysosomal enzymes in digesting food.

大多数动物的消化道在消化食物时,很少有赖于溶酶体的酶。

Analyzing the change of DH, PCL and active calcium, and selecting each of best method. The results:(1) Dealing with the bone under high pressure ①High content of protein in sheep bone or bone soup:0.05MPa, 2h, 1:2;②Low amino acids in bone powder:0.13MPa, 4h, 1:3; Low amino acids in bone soup: 0.10MPa, 3h, 1:4;(2) Hydrolysis the bone soup with enzymes ①High content of calcium: neutral enzyme, 1500u/L, 6h;②High DH: pancreatic enzyme, 1:100, 6h;③ Low PCL: Pancreatic enzyme, 1:125, 6h; High PCL: alkalescency enzyme,

结果表明:A、高压①骨粉及骨汤蛋白质含量最高:压力为0.05MPa,高压2.0h,骨水比为1:2;②骨粉中氨态氮最低:压力0.13MPa,高压4.0h,骨水比为1:3;骨汤中氨态氮最低:0.10MPa,3.0h,骨水比1:4;B、酶解①游离钙含量最高:中性蛋白酶,酶浓度1500u/L,酶解6h;②水解度最高:胰蛋白酶,酶浓度1:100,酶解6h;③PCL值最低:胰蛋白酶,酶浓度1:125,酶解6h;PCL值最高:碱性蛋白酶,酶浓度1500u/L,酶解8h。

The results:(1) Dealing with the bone under high pressure ① High content of protein in sheep bone or bone soup:0.05MPa, 2h, 1:2;② Low amino acids in bone powder:0.13MPa, 4h, 1:3; Low amino acids in bone soup: 0.10MPa, 3h, 1:4;(2) Hydrolysis the bone soup with enzymes ① High content of calcium: neutral enzyme, 1500u/L, 6h;② High DH: pancreatic enzyme, 1:100, 6h;③ Low PCL: Pancreatic enzyme, 1:125, 6h; High PCL: alkalescency enzyme,

结果表明: A 、高压①骨粉及骨汤蛋白质含量最高:压力为0.05MPa ,高压2.0h ,骨水比为1:2;②骨粉中氨态氮最低:压力0.13MPa ,高压4.0h ,骨水比为1:3;骨汤中氨态氮最低:0.10MPa ,3.0h ,骨水比1:4; B 、酶解①游离钙含量最高:中性蛋白酶,酶浓度1500u/L ,酶解6h ;②水解度最高:胰蛋白酶,酶浓度1:100,酶解6h ;③ PCL 值最低:胰蛋白酶,酶浓度1:125,酶解6h ; PCL 值最高:碱性蛋白酶,酶浓度1500u/L ,酶解8h 。

Benzene undergoes metabolic oxidation by cytochrome P450 enzymes to form an electrophilic epoxide which can alkylate protein and DNA.

苯在细胞色素P450酶氧化代谢下,形成一种能烷化蛋白质和DNA的电环氧化物。

It is created when enzymes break down the amino acid arginine.

这是创建时的酶分解精氨酸的氨基酸。

The results are related, among other things, to starch granule stability in the presence of amylase enzymes.

该结果与淀粉粒在淀粉酶存在条件下的稳定性有关。

Yet amyloid and enzymes are important for health and scientists do not want to destroy them completely.

然而amyloid和酶都是维持健康所必须的,科学家们不想全部摧毁他们。

These include studies of enzymes that act on proteins to produce the plaques, and using antibodies against amyloid.

这包括对作用于蛋白质产生plaques的酶的研究和运抗体抵抗amyloid。

Treated with alkaloid monomers, the activities of protective enzymes showed gradual increasing in prophase and deceasing in anaphase.

在供试的生物碱单体中,保护酶活性表现出前期升高,后期降低的趋势。

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According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。