查询词典 endosome

This review focuses on the development and means of the modification of polymeric gene vectors making them have multifunction, i.e. the ability to maintain stability outside of cell, the ability of cell entrance, endosome escape, and the ability of nuclear membrane traversing. The main challenges remain and the future direction of polymeric vectors research are discussed.

本文在分析基因治疗过程的基础上，详述了基因载体应具有的4种基本功能－在细胞外保持稳定的功能、进入细胞的功能、逃离溶酶体的功能和进入细胞核的功能，并详细介绍了有关基因载体功能化修饰的方法和目前国际上的进展情况，总结了高聚物载体目前存在的主要问题及未来的发展方向。

It exists in early endosome, multivescular bodies and perinuclear recycling compartment.

胆固醇耗竭剂能改变它的分布，提示它与膜和蛋白的分选有关。

The LDL and its cholesterol separate in the endosome; the LDL is sent on to the lysosome, where it is degraded, and the cholesterol is released for use by the cell.

LDL和胆固醇在内吞体中是分离的；LDL被发送到溶酶体，在溶酶体中它被降解，并且细胞释放胆固醇供使用。

This review focuses on the development and means of the modification of polymeric gene vector making them have multi-function—the ability to maintain stability outside of cell、the ability of cell entrance、the ability of endosome escape and the ability of nuclear membrane traversing, at last, we highlight the main challenges that remain and the future direction of polymeric vectors research.

本文在分析基因治疗过程的基础上，详述了基因载体应具有的四种基本功能——在细胞外保持稳定的功能、进入细胞的功能、逃离溶酶体的功能、进入细胞核的功能，并详细介绍了有关基因载体功能化修饰的方法和目前国际上的进展情况，最后本文总结了高聚物载体目前存在的主要问题及未来的发展方向。

Results①The Rab9 and NPC1 colocalized in cytoplasm of microglia.②Rab9 expressed in lysosome,Golgi apparatus and late endosome.

结果Rab9和NPC1共定位于小胶质细胞胞浆内，Rab9表达于溶酶体、高尔基体和晚期内体。

The ESCRT-III complex mediates membrane budding away from the cytosol in endosome biogenesis, cytokinesis, and viral budding.

ESCRT-III复合体能够在没有内涵体胞浆、胞浆移动和病毒芽殖的情况下，介导细胞膜的芽殖。

The researchers have confirmed, in a wide range of cells, that nanoparticles are taken into a region called the endosome, where this essential coating is degraded by cathepsin L.

赛尔博士表示，利用纳米粒子作为药物传递工具是很有前途的应用，但要使这样的生物疗法奏效，粒子外层蛋白就要保持高度完整，但组织蛋白酶L的降解作用将会致使药效减弱。

On the other hand, immunoGrB was found inactive in transient and stable transfection research until when translocating from endosome in HER-2 positive tumor cells, it turned into an active form.

另一方面，从瞬时转染和稳定转染角度研究证实，immunoGrB分子不具有杀伤活性，它只有当特异性内化入HER-2阳性肿瘤细胞后才转变为活性形式。

These results indicate that DENV is transported to the autophagosome by early endosome and triggered membrane fusion in the amphisome. This study also suggests that time-lapsed dual fluorescent microscopy system can be a powerful tool to investigate the intracellular trafficking of virus.

除此之外，透过本研究说明时间序列萤光影像显微技术为一个有力的应用工具，在未来能藉由此技术，进一步厘清病毒与宿主细胞在病毒生活史上每一个环节之间的关系。

Meanwhile, we found the colocalization of mRabL5 with WGA-positive endosome by immunofluorescence assay, which further demonstrated that mRabL5 may cycle between cytolsol and membrane system to facilitate endocytosis pathway.

利用该抗体，我们检测到mRabL5是一个广谱表达的蛋白，与TGN共定位，作为一种小G蛋白，循环于膜系统和胞质之间，参与内吞途径。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。