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The 20S catalytic core of the 26S proteasome has the shape of a barrel made of four rings which are composed of seven differentαsubunitsα_1-α_7 at two outer rings and seven differentβsubunitsβ_1-β_7 at two inner rings at which the catalytic sites locate. Three of theβsubunits contain proteolyses sites, which are sequestered in the hollow interior of the 20S particle. Substrates enter the 20S through a narrow channel formed by theβsubunits, whose N-termini, depending on their conformation, can either obstruct or allow substrate entry and thus function as a gate. This entry channel is narrow and only permits passage of unfolded, linearized polypeptides.

哺乳动物26S蛋白酶体是由一个20S催化颗粒(catalytic particle，CP)和两个19S调节颗粒(regulatory particle，RP)组成的ATP(adenosine-triphosphate，ATP)依赖性蛋白水解酶复合体。20S CP是26S蛋白酶体的催化核心，它是由4个圆环堆叠形成的桶状复合物，其中两侧外环每个环是由α_1-α_7亚基组成，两个内环每个环是由β_1-β_7亚基组成，4个环的中央形成一个狭窄的内腔。2个β内环形成了20S CP的催化中心空腔，其内壁为催化活性位点所在地；外侧α环中心的孔道是底物到达催化中心空腔的通道，一般被α亚基上的N末端所封闭，阻止胞内非目的靶蛋白进入20S CP内被降解破坏。

As Ray Barrell, senior research fellow at the National Institute of Economic and Social Research, the think-tank, says:"Either growth will have to slow markedly or the exchange rate must fall to cover the deficit." But there is no immediate imperative for this to happen.

正如智囊机构国家经济社会研究院(National Institute of Economic and Social Research)的高级研究员雷·巴雷尔所言："要弥补赤字，要么必须明显放缓经济增长，要么必须降低汇率"但是，这一切还不是很紧迫。

As Ray Barrell, senior research fellow at the National Institute of Economic and Social Research, the think-tank, says:"Either growth will have to slow markedly or the exchange rate must fall to cover the deficit."

正如智囊机构国家经济社会研究院(National Institute of Economic and Social Research)的高级研究员雷。

"It's either that or cut teachers," Barrette said. Schools are about kids.

"要么这样，要么就得减少教师人数，"巴雷特说，学校是为孩子们开的。

Let's you modify the base font size to either make it larger or smaller.

"="让你修改基础字型的大小。

For example, if you set the angle values here to Start Angle=0 and End Angle=45, the particles are emitted within a total of a 90-degree cone, with 45 degrees on either side of the base vector.

例如，如果用户设置起始角度值为0，结束角度值为45。那么粒子将在总共为90度的锥角内发射。也就是在基本向量两边都为45度角的椎体体积内。

His face is as red as an apple. Nobody knows either his bashfulness or the alcohol makes it.

他的脸红得像苹果，也不知是羞怯，还是酒精闹的。

It probably reflects either male boasting or female bashfulness, but though it affects totals it does not seem to affect trends.

这可能反映了男性的自夸或者是女性羞赧，虽然它影响到了总数但是似乎没有影响到趋势。

Several years later, out of the palace where such a thing: a few farmers sold the timber to empty parked in the palace before either of these cars pulled cattle, some with horse-drawn, in which a farmer, he spent a 3 Malay pull carts, there is a Basho had a small pony, small pony ran to pull another car the middle of the two cows.

几年之后，王宫里出了这样一件事：几个农民卖完了木材，把空车停在了宫前，这些车有的是用牛拉的，有的是用马拉的，其中一个农夫，他用了三匹马来拉车，有一匹马生了一头小马驹，小马驹跑到了拉另外一辆车的两头牛中间。

And in regards with Portia, who is also faced with a choice among the rich princes and the poor yet romantic Bassano, she doesn't hesitate, either.

片中，一个美国女人被阿拉伯国家练枪的小孩打伤，而他的猎枪则是一名日本游客送给他爸爸的礼物。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。