查询词典 effect binding

Study on molecular characters of atagonist indicated that neonicotinoids insecticides and the active pharmaceutical group displayed electro-negative and electro-positive, and study on the interaction between atagonist and nAChR at the complex of subunit of insect and subunit of mammalian indicated that the effect of basic aminoacid in D ring of binding location of ACh is very obvious, and the YXCC in C ring of binding location also attracted the attention too.

激动剂的分子特点研究表明，新烟碱类杀虫剂和ACh药效基团在静电性上分别显示负电性和正电性。用昆虫亚基和脊椎动物亚基组成的杂合受体同激动剂相互作用的研究，主要集中在受体亚基上不同氨基酸残基与不同激动剂结合电生理效应的特点上。

11 The facilities hereby expressed to be granted to the Borrower may be utilized or drawn down by all or any one or more of them AND the repayment and other obligations of the Borrower hereunder shall continue to be binding upon all of them notwithstanding that not all of them may from time to time or at any time have been making use of the facilities hereby expressed to be granted or that such facilities may be utilized by all or any one or more of the Borrower in different proportions AND shall continue in full force and effect and be binding upon all the persons comprising the Borrower and any of them not released by the Lender from their obligations hereunder notwithstanding the liquidation or cessation of business of any of the Borrower or the release by the Lender of any one or more of the Borrower from any or all of their obligations hereunder AND no arrangement between the Borrower and their successors or assigns shall prejudice the right of the Lender to pursue the remedies against any one or more of them and in such order and manner as the Lender may think fit and the relationship between the Lender and/or the Borrower shall be that of principal and debtors and no giving of time or indulgence to or release of any one or more of the Borrower shall affect the right of the Lender to pursue the remedies against the other or others as if such giving of time indulgence or release had not been made

18.11 根据本契据明文规定批予借款人的信贷安排，可由借款人全部各人或任何一人或多人使用或提取，而借款人根据本契据承担的还款及其他义务须继续对全部各人具约束力，即使并非全部各人皆不时或在任何时间利用根据本契据明文规定批予的信贷安排，或即使信贷安排可能由借款人全部各人或任何一人或多人按不同比例使用，借款人根据本契据承担的还款及其他义务仍须继续对全部各人具约束力。即使借款人任何一个清盘或停业，或贷款人已解除借款人任何一个或多个在本契据中的任何或全部责任，借款人根据本契据承担的还款及其他义务须继续有效，并对借款人所包括的全部各人及当中任何未获贷款人解除本契据义务的人士具约束力；借款人、其继承人或受让人之间的安排，不得妨碍贷款人以其认为合适的次序及方式针对借款人及其继承人／受让人任何一人或多人采取补救方法的权利，而贷款人及／或借款人之间的关系须为债权人与债务人之间的关系，借款人任何一人或多人获延期、宽限或免除责任，均不得影响贷款人针对其他一人或多人采取补救方法的权利，犹如从未作出延期、宽限或免除责任一样。

In Chapter 6, an extensive kinetic study of the inhibition of ribonuclease A and papain by urea has been performed. The results suggest that the effect of urea on activities of these enzymes can be well described by the denaturant binding model. The binding constants of urea determined by the present method are nearly identical to that determined from a variety of different studies on model compounds and proteins.

我们在第六章中研究了脲作用下核糖核酸酶A和木瓜蛋白酶的抑制动力学，发现变性剂结合模型可以很好地描述脲对这两个酶活力的影响，而且用我们自己建立的方法测得的脲与蛋白质的结合常数与前人通过对模型化合物和某些蛋白质的研究所获得的数值基本一致。

Now we have known that SARS-CoV encoded 11 varietal proteins. They have 4 constitutive proteins: spike protein, membrane protein, envelope protein and nucleocapsid protein. Spike protein trimer form spike and exsertion? virus peplos on the surface. Spike protein is archi-surface antigen component of virus, it has acceptor binding and membrane fusion activity. Spike protein has important effect at tissue tropism, cell-fusion and toxicity. Nucleocapsid protein can bind genome RNA to shape neucleocapsid. Membrane protein and envelope protein are necessary constituent to shape virus peplos. Spike protein is I-type membrane glycoprotein, it mediate virus binding with host cell epimembranal acceptor and to fuse host cell membrane.

SARS-CoV属于巢状病毒目、冠状病毒科，为单正链RNA病毒，基因组全长约29.7kb，已知编码11种蛋白，其中包括4种结构蛋白，分别是刺突蛋白、包膜蛋白、小包膜蛋白和核蛋白或核壳体蛋白。S蛋白三聚体形成突起，伸出包膜表面。S蛋白是病毒的主要表面抗原成分，具有受体结合和膜融合活性，在组织嗜性、细胞融合和毒力等方面起重要作用。N蛋白与基因组RNA结合形成核衣壳。M蛋白和E蛋白是包膜形成所必需的成分。

Using HPLC separation and receptor binding assay, the present study demonstrated that the principle in the water extract of Huangqin acted on the BDZ binding site was not baicalin, wogonin or chrysin. In vivo study, WEH had no significant effect on pentylenetetrazol-induced clonic seizures in mice, although it could inhibitmaximal electroshock-induced tonic seizures with an ED50 of 3.6g/Kg.

本研究中，藉由高效率液相层析术与接受器结合实验评估，证实黄苓水抽提物中作用在BDZ结合处之主要成分，并不是黄苓甘、泛黄苓素或chtysin。

Objective: To observe the effect of plasmid DNA binding to sarcoplasmic reticulum non-nuclear DNA binding proteins on SR function.

目的：观察DNA与骨骼肌肌质网蛋白结合后对肌质网功能的影响。

In the second part, the current-voltage characteristics of the sensors were measured, their charge ionic mobilities were measured with polar inversion method and their ionic numbers were computed. It has found that ionization effect of some binding ions against a critical humidity took place in switchable humidity-sensitive materials, the effect is that some binding ions in materials turn into free ions when a given ambient humidity is reached called a critical humidity, avalanching conduct electricity occurs in materials.

在第二部分中，测试了高分子电阻型湿敏元件和开关型湿敏元件的伏—安特性，并用极性反转法测试了其导电离子的迁移率以及计算了相关的导电离子数目，发现了开关型湿敏元件的束缚离子的最小湿度电离效应：当环境湿度达到或者大于一特定湿度时，这一特定湿度称之为最小湿度，材料中某些束缚离子才电离成自由的导电离子，形成雪崩式导电。

Moreover, the result about the inhibitory effect on ryanodine binding of concentrated chelators indicates that using proper concentrations of chelators is essential in ryanodine binding assays.

此外，高浓度螯合剂抑制ryanodine结合的结果还表明，在ryanodine结合实验中，使用的螯合剂浓度不能过高。

The dose-dependent experiment revealed that Id1 antagonised E47 and Ets1 mediated transcriptional activation in a dose-dependent manner. With pGL3-870 as a template, site-directed mutagenesis of E-box and / or ETS-binding site was introduced into p16 promoter. E47 could not activate the transcription of p16 promoter with E-boxes mutated, and Ets1 could not activate the transcription of p16 promoter with EBS mutated. The synergy effect between E47 and Ets1 would occur only if the E-boxes and EBS were present. These facts demonstrated that E47 and Ets1 proteins were not recruited to the promoter by binding to other cis-elements or through interaction with other protein factors, however, they bound to DNA directly through respective consensus sequences in p16 promoter.

以pGL3-870为模板，构建了E-box或/和EBS点突变的p16启动子报告基因载体，将野生型和突变型的报告载体分别与pI-E47、pI-Etsl以及pI-E47+pI-Ets1共转染，发现E47和Ets1所诱导的转录激活作用依赖于启动子DNA上存在的各自的特异结合序列，二者的协同作用也只有当两个结合位点都存在时才会发生，说明E47和Ets1不是与其它作用元件或其它蛋白质因子相作用而被招募到该启动子的，它们是通过启动子上各自的特异结合位点与DNA直接结合的。

The stimulatory effect on the MMP-13 promoter was partially inhibited by mutation of the osteoblast-specific element 2 (OSE-2) binding site ⑸ Core binding factor-1 (Cbfa-1) expression peaked at 7 days ⑹ of differentiation, and was phosphorylated by PKG in itro.

免疫组织学检查揭示在17天大的embryo iNOS缺乏的老鼠MMP-13和Cfba-1表达水平均降低。Cfba-1 mRNA的沉默阻滞MMP-13的表达，不影响内源性的NO产生，肯定了他在MC3T3-E1细胞中NO诱导的MMP-13的表达中的作用。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。