查询词典 dystrophin

Some of the recessive forms have been associated with defects in proteins that make up the dystrophin-glycoprotein complex.

一些隐性的形式已与缺陷的蛋白质，弥补肌营养不良蛋白糖复杂。

Whatever mutations are, they all lead to defect of dystrophin on sarcolemma.

由于二者病程和功能影响程度不同，正确区分非常必要。

Transcription, western, and immunohistochemical analysis showed increased levels of dystrophin transcript and protein, and correct localization at the sarcolemma.

用免疫组织化学分析用纳米作为载体进行寡聚核苷酸递送的实验鼠抗肌萎缩蛋白基因RNA和抗肌萎缩蛋白的水平得到提高，而且恢复了抗肌萎缩蛋白在肌肉细胞膜上的正确位置。

Deletions that terminate in in-frame codons, do not prevent translation of dystrophin and result in a truncated protein, still able to bridge actin and sarcolemma.

缺失的终止在框架密码子，并没有妨碍在截短的抗肌萎缩蛋白翻译和结果，仍然能够弥合肌动蛋白，肌膜。

ObjectiveDuchenne and Becker muscular dystrophy is the most common human X-linked recessive inherited disease.The absence of dystrophin on the sarcolemma results in DMD,which is the essential physiopathologic mechanism.

假肥大肌营养不良是男性最常见的X-连锁隐性遗传病，而肌营养不良蛋白在DMD患者肌细胞上的表达异常是导致该病发生的最根本的病理生理机制。

Methods:The whole mature protein coding sequence of three truncated dystrophin gene was amplified by RT-PCR method applied to human muscle cDNA. The fragment was inserted into prokaryotic expression vector pET28a plasmid.

以人肌肉组织cDNA为模板，采用RT-PCR扩增三个截短的肌营养不良蛋白cDNA，分别克隆入原核表达载体pET28a中，经限制性内切酶双酶切及DNA序列分析鉴定目的基因。

A solid-phase assay using the dystrophin glycoprotein complex showed that the mutation did not affect the binding of agrin to alpha-dystroglycan.

通过肌营养不良蛋白复合体的固相测定显示，突变没有影响α-肌营养不良蛋白聚糖。

Dystrophin was strongly expressed on arrector pili muscle cells of all control patients (94.6%) except two cases in whom it was weakly expressed.

在utrophin蛋白表达方面杜氏进行性肌营养不良和贝克型进行性肌营养不良和对照组都有强的表达。

Cell-based therapy is a promiseful option.This review will focus on the present status of cell-based therapy.Myoblast transfer therapy is hindered by minimal distribution of cells after injection,immune rejection,and poor cell survival.The drawback of bone marrow...

成肌细胞移植面临的主要限制是注射后细胞分布差，免疫排斥和细胞存活率低；骨髓干细胞移植需要解决横向分化的低效率问题；而肌源性干细胞看来能更有效地再生表达dystrophin的肌纤维。

Background and Objective Pseudohypertrophic muscular dystrophy is a kind of lethal X-chain recessive inherited disease. The etiological factor is mainly due to gene mutation of Xp21 which induce the structural and functional abnormality of a kind of cell skeleton protein: dystrophin.

背景和目的假肥大型肌营养不良症(pseudohypertrophic muscular dystrophy，PMD)是一种常见的致死性X-连锁隐性遗传病，病因主要是由于X染色体短臂2区1带(Xp21)的基因突变而导致一种细胞骨架蛋白——抗肌萎缩蛋白的结构和功能异常所致。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失