查询词典 drynaria rhizome

Methods We isolated and cultured the MSCs, then induced MSCs into osteoblast and checked the osteoblast by RT-PCR; the conditioned medium in different concentration was prepared containing diphosphonate or assemble flavone of drynaria rhizome; with the conditioned medium the osteoblast was cultured; then the growth curve was analyzed and the cytogene (collagenase col Ⅰ) col Ⅰ and ALP expression was detected.

使用诱导方法作用于骨髓基质干细胞，使之转化为成骨细胞；用RT-PCR检验成骨细胞；不同浓度的二磷酸盐或骨碎补总黄酮配制成条件培养基，作用于成骨细胞，并分析生长曲线，分析细胞基因碱性磷酸酶和胶原酶Ⅰ(collagenase col Ⅰ)表达情况。

Objective To study effects of diphosphonate and assemble flavone of drynaria rhizome on the osteoblast at the level of molecule.

目的 探索二磷酸盐和骨碎补总黄酮联合作用如何在分子水平发挥作用于成骨细胞，揭示其效果如何。

The results of empirical study to illustrate that the flavone of rhizome drynaria has considerable significance to improve the bone formation action of SOP.

实验研究结果说明，骨碎补总黄酮对增强老年性骨质疏松症成骨作用具有重要的意义。

To illustrate that the flavone of rhizome drynaria can improve proximate of femur bone strength, and prevent fracture of hip.

说明骨碎补总黄酮对老年性骨质疏松症具有提高整体骨量的作用，同时能够提高股骨近端骨强度，预防髋部骨折。

To illustrate the flavone of rhizome drynaria can extently amend the lumbodosal pain and lumbodynia with SOP, the pain obviously released after 3 months.

说明骨碎补总黄酮在一定程度上能够改善老年性骨质疏松症引起的腰背痛及腰痛，缓解疼痛的幅度以治疗的前3个月最为明显。

Senile Osteoporosis;flavone of rhizome drynaria;osteogenesis;clinical study;experimental study

老年性骨质疏松症；骨碎补总黄酮；成骨作用；实验研究；临床研究

From the theoretical angle, to analyze and summarize the morbility reason of Senile Osteoporosis, to approach the effect of the flavone of rhizome drynaria on the lipidision of marrow stroma cell, as well as the senescence and apoptosis of osteoblast through the experimental study; from the clinical angle, to observe the clinical effect of the flavone of rhizome drynania on Senile Osteoporosis, to supply scientific theory basis for clinical application.

从理论角度分析总结老年性骨质疏松症的发病原因，并通过实验研究探讨骨碎补总黄酮对骨髓基质细胞脂质化的影响，以及对成骨细胞衰变和凋亡的影响，从临床角度观察其治疗老年性骨质疏松症的效果，为临床应用提供科学理论依据。

Results We can induce MSCs into osteoblasts which can express gene col Ⅰ and ALP. Through analysis growth curve, we demostrateed the diphosphonate or assemble flavone of drynaria rhizome with 10^(-4)~10^(-6)mmolL^(-1) had the inhibition on the osteomast; it with 10^(-8)mmolL^(-1) had a promotion on the osteoblast; it with 10^(-10)~10^(-12)mmolL^(-1) had a restraint on osteoblast. Conclusion Through gene analysis, we found the diphosphonate or assemble flavone of drynaria rhizome can have the promotion on the osteoblast.

结果 骨髓基质细胞经过4周诱导可转化为表达colⅠ和ALP的成骨细胞，经过生长曲线分析，二磷酸盐和骨碎补总黄酮10^(-4)~10^(-6)mmolL^(-1)时，对诱导后的成骨细胞有抑制作用；10^(-8)molL^(-1)有促进作用；10^(-10)~10^(-12)mmolL^(-1)不明显，其中10^(-8)mmolL^(-1)作用最强；基因分析后，发现二磷酸盐和骨碎补总黄酮促进成骨细胞表达colⅠ和ALP，且两者合用效果大于单独用药。

After 6 months treated, the SOP patients' ICTP lowered extently, to illustrate that the flavone of rhizome drynaria can delay the bone resorption.

运用骨碎补总黄酮治疗6个月后，ICTP有一定程度上降低，说明骨碎补总黄酮具有减缓低转换型骨质疏松症骨吸收状况的功效。

Experimental study indicated: the flavone of rhizome drynaria can improve the cytoactive of marrow stroma cell of rats, promote its multiplicative division, and protect the marrow stroma cells' apotosis with lipidsion.The flavone of rhizome drynaria's serum can extently protect the osteoblast apoptosis of rats induced by TNF-α and the osteoblast senescence of rats induced by t-BHP.

实验研究表明：骨碎补总黄酮能够提高大鼠骨髓基质细胞的活性，促进其增殖分裂，并对脂质化大鼠骨髓基质细胞凋亡具有保护作用，而且骨碎补总黄酮含药血清对TNF-α诱导的大鼠成骨细胞凋亡和t-BHP诱导的大鼠成骨细胞衰老均具有一定的保护作用。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。