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Article 16 Investigational study of new drugs conducted for application for drug registration shall include the synthetic techniques, extraction methods, physical and chemical properties, purity, choosing of form of this drug, selection of prescriptions, preparation techniques, inspection methods, quality indications and stability, pharmacology, toxicology, nuclein animal dynamics etc.

第十六条为申请药品注册而进行的药物临床前研究，包括药物的合成工艺、提取方法、理化性质及纯度、剂型选择、处方筛选、制备工艺、检验方法、质量指标、稳定性，药理、毒理、动物药代动力学等。

PEG-PBLG micelles are characterized by solubilizing hydrophobic drug, increasing the nano-particles stability, avoiding the uptake by MPS at some extent, and decreasing opsonization by plasma proteins, sustained-release drug and decreasing the side effect.

PEG-PBLG载体材料结构明确，合成产率高，可生物降解；PEG-PBLG胶束可增溶疏水性药物，增强微粒制剂的稳定性及一定程度避免MPS的摄取，减小血浆蛋白的调理；载药胶束可缓释药物，降低药物毒性。

Methods: forty nine patients with prostatic cancer, 14 patients at pathologic stage c, 35 stage d, were analyzed retrospectively. twenty one of them were treated by bilateral orchidectomy and castration of drug; twenty three of them were treated by consist castration of drug;five patients were treated by intermittent androgen suppression.

对49例中晚期前列腺癌患者的临床资料进行回顾性分析。49例分为a、b、c 3组，a组21例行双侧睾丸切除+药物去势，b组23例给予持续性药物雄激素阻断，c组5例行间歇性药物雄激素阻断，分析3组的症状缓解率、影像学评价有效率、前列腺特异抗原psa）反应率及1、2、3年的生存率。

Any special design features of the drug product (e.g., tablet score line, overfill, anti-counterfeiting measure as it affects the drug product) should be identified and a rationale provided for their use.

需应标明制剂的所有设计特性（如：药片标记线、过度充填、反伪造措施），并提供使用他们的理由。应提供这些特性的适宜性的支持信息。

This paper is mainly comprised of two components:preparation of models of rats suffering from deficiency of spleen Yang;comparison of the pharmacodynamics impacts of different Lizhong Pills formulations made up by dried ginger or its different components in Lizhong Pills to the different groups of the models.1 Establish the model of deficiency of spleen YANG induced by " cypsum fibrosum and anemarrhenae " with complex factors1.1 ObjectivesWith using heat-clearing and fire-purging drug cypsum fibrosum and anemarrhenae,insteading of the common usage of rhubarb and folium sennae,accompanied with irregular diet and overstrained,the model of deficiency of spleen-YANG is to be established,which is much close to the pathopoiesis theory of " frigidity and chilly damaging yang,irregular diet injuring qi,overstrain impairing the spleen" in TCM.1.2 MethodsModel rats is fully fed every other day,given the molding drug of cypsum fibrosum -anemarrhenae(concentration 4:1) with 3 different frequency,and arranged to swim everyday in 25℃water until exhausted(performing as spitting bubble 3 times continuously or sinking unable to float by itself).

全文共分为脾阳虚模型的制备和干姜及其成分对理中丸药效学影响的比较两大部分。1&石膏-知母&复合法脾阳虚模型的制备1.1目的以清热泻火药石膏-知母代替常用的大黄、番泻叶类苦寒泻下药，并结合饥饱失常、劳倦过度的方法进行造模，以期建立更符合中医&寒凉伤阳、饥饱伤气和劳倦伤脾&致病思路的中医脾阳虚证候模型。1.2方法模型动物隔日足量喂食，每日在25℃水中游泳，直至大鼠连续三次吐泡下沉，或沉入水底，3秒内不能自行浮出水面，并以三种不同给药频率灌胃给予石膏一知母煎液，比较石膏-知母不同给药方法对制备脾阳虚模型的影响。

Electroencephalographys were detected in SE and SC groups after 2 h of drug injection. Long term potential at perforant pathway and dentate gyrus and EEG were recorded in LE and LC groups after two weeks of drug injection.

注射药物2 h后，SE和SC组检测脑电图；药物注射后2周，LE和LC组检测内嗅区前穿通纤维-海马齿状回长时程增强和EEG。

To facilitate the applications of biologically functional protein in drug design, it is necessary to have a thorough understanding of their conformations and their interactions with the receptors. NMR spectroscopy has the unique ability to retrieve information about 3D structures of proteins and their interactions with the target proteins in solution. Many NMR techniques have been used to study a number of pharmaceutically important proteins and characterize their interactions with the targets. In this review, we will introduce these NMR methods and show how to utilize them for protein drug design.

为了设计具有生物功能性的蛋白质来当作药物，我们必须对其蛋白质结构与其受体在结合时的作用有完整清楚的了解，而核磁共振光谱具有独特的能力，可以获得溶液状态下蛋白质结构以及蛋白质与标的蛋白质交互作用间的资讯，目前已有许多核磁共振光谱技术运用到蛋白质药物的研究，并确认它们与其标的蛋白质间的作用模式，笔者将在本文中介绍这些技术，以及如何运用它们来获取重要资讯，俾设计蛋白质药物。

This drug must have a dual purposes on cure and prevention, so the selection of pharmacokinetical and pharmacodynamical functional group should be prior to endogenous substances in human body, and the drug should have the feature of low poison.

铅中毒是一种严重危害人类健康的疾病，它对机体的损害早在出现临床症状以前已经存在，从而提出了亚临床症状性铅中毒的概念。

In the preformulation studies, UV absorption characteristics, solubility and stability of the drug in the different media were determined, the physico -chemical compatibility between the drug and nine kinds of excipients was observed using DSC analysis.

在处方前研究中，对盐酸尼卡地平的紫外吸收特性、不同介质中的溶解度和稳定性进行了测定，并利用DSC法考察了该药物与九种辅料（EC，HPMC，PVP，PEG6000，MCC，乳糖，淀粉，硬脂酸镁，SLS等）间的物理化学相容性。

The main three parts of the present study are: the preformulation study involving screening the proper enhancers for transdermal aborption of α-asarone;Formulation study and developing a drug-in-adhesive transdermal patch of α-asarone using Eudragit E100 as pressure sensive adhesives;The α-asarone reservoir patch was prepared using 1 %HPMC of ethanol solution as medium and EVA membrane for controling the release of drug, and do the research its bioavailability.

主要内容有以下三个方面：药物经皮吸收制剂开发的处方前研究工作；采用Eudragit E100为压敏胶材料，进行了α-细辛醚胶粘剂分散型贴片的研究；以1%的HPMC的醇性溶液为储库介质，以EVA膜为控释膜，进行了α-细辛醚储库型贴片和生物利用度的研究。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。