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Objective The anticogant to the endotheliotoxin receptor is a promising drug to treat with the pulmonary arterial hypertension therotically.But in our country there was few systemical clinical trial about the drug used in the disease.We study the curative effect and the side effect of an anticogant to the endotheliotoxin receptor-Tetramethylpyrazine on the pulmonary arterial hypertension.Methods The64newborn patients were continually main line the tetramethylpyrazine by the mini pump and stimutaneously treated with the respiratory machine.The injec-tion speed was controlled from5μg/kg·min to10μg/kg·min,or to20μg/kg·min.

目的 探讨内皮素受体拮抗剂—阿魏酸钠微量泵持续静脉注射治疗新生儿肺动脉高压的疗效和不良反应方法对64例肺动脉高压的新生儿在呼吸机械通气的情况下同时用微量泵持续静脉注射阿魏酸钠，阿魏酸钠微量泵静脉注射的速度由5μg/开始，在保证体循环血压的基础上可以逐渐加量至10μg/，直至20μg/。

This investigation provided a new theoretical tool for studying the diffusional release of drug from an erodible polymeric matrix and designing the controlled released drug .

这对研究药物从高聚物基质内的释放问题以及控释制剂的设计具有重要的意义。

Researchers found that maternal illicit drug use and pre-eclampsia were associated with a significantly increased risk for hypothermia in preterm neonates. In hypothermic preterm neonates, 4.2% of mothers reported illicit drug use, compared with 2.5% of euthermic neonates ( P ?=.04). Maternal pre-eclampsia occurred in 33% of hypothermic neonates and in 17% of euthermic neonates P ?.

研究者发现，母亲使用非法药物与先兆子痫和早产儿增加低温风险有关；低温的早产儿中，4.2%的母亲有使用非法药物，适温新生儿的母亲则只有2.5%(P=。04)；低温的早产儿中，33%的母亲发生先兆子痫，适温新生儿则只有17%(P.001)。

The application of CNI drug avoidance protocols to high-risk recipients (retransplants, highly sensitized, etc.), extrarenal allograft recipients, or alternative drug regimens such as steroid or MMF elimination should be subjected to controlled trials.

对于高危患者（再次移植、高度致敏等等）、除肾脏外其他器官移植患者、采用激素或MMF撤除的药物调整，该项避免CNI类药物应用的方案仍需要进一步对照实验。

Part at giving drug before (T1), time of zymogen of the blood pressure of the 5 Min(T2) after giving drug, 30 Min(T3), 60 Min(T4) that monitor, serous cruor (enzymatic time of work of cruor of PT), fractionary activation , thrombin , fibrinogen and plaque computation .

分别于给药前(T1)，给药后5 min(T2)、30 min(T3)、60 min(T4)监测血压、血浆凝血酶原时间、部分激活凝血活酶时间、凝血酶时间、纤维蛋白原含量及血小板计数。

The thermosensitive drug-loading to PNIP/AAm nanogel and drug release profile of in situ gelable PNIP/AAm nanogel dispersion were studied.

3研究了PNIP/AAm纳米凝胶粒对药物的温敏性负载及可原位凝胶化的纳米凝胶分散体原位凝胶对药物的释放行为。

Anti-hypertension drug usage in cases accounted for 22.45%, ranking first, and lower glucide drug and the traditional chinese medicine usage follewed in order, accounting for 11.56% and 10.88% of the total case medicine usage, respectively.

病例组长期服药史中以服用抗高血压类药物最多(22.45%)，其次为降糖类药物(11.56%)和中药类药物(10.88%)。

Key words: non gonococcal urethritis; ureaplasma urealyticum; mycoplasma hominis; drug tolerance; drug sensitivity

关键词］非淋菌性尿道炎；解脲支原体；人型支原体；药物敏感性

Medicines GMP certification of enterprise, the production of a new drug, pharmaceutical supervisory and administrative departments shall accept: hacky priority to 30 June 1998 any medicines GMP authentication enterprise, the pharmaceutical supervisory and administrative departments will no longer accepts drug production application.

取得药品gmp认证证书的企业，在申请生产新药时，药品监督管理部门予以优先受理：迄至1998年6月30日未取得药品gmp认证的企业，药品监督管理部门将不再受理新药生产的申请。

Drug sensitivity tests showed that the resistance to gentamycin,levofloxacin,trimethoprim/sulfamethoxazole,rifampin,erythromycin,elindamycin and tetracycline were hish among MuH and MuL strains,and most of these strains were multi-drug resistant.All strains were susceptible to vaneomycin.

药物敏感性试验显示，MuH和MuL菌株对庆大霉素、左氧氟沙星、复方磺胺甲恶唑、利福平、红霉素、克林霉素、四环素的耐药率都较高，且呈多药耐药，但对万古霉素全部敏感。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。