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A major UPR protective response is the induction of the ER chaperone GRP78/BiP, which is expressed at high levels in a variety of tumors and confers drug resistance in both proliferating and dormant cancer cells.

该模型的小鼠Grp78的表达水平是正常的一半,模拟了抗Grp78药对Grp78表达的部分抑制作用。

If that were the birthmark of genius, he said, genius would be a drug in the market.

177"倘若那是天才的胎记,"他说,天才就成了市场上的滞销货啦。

Methods Normal group,HepG2 model group,groups of HepG2 cells treated with compound methionine and choline bitartrate at different concentrations,L02 model group,and model groups of L02 cells treated with drug at different concentratrions were set up.

目的 对比油酸诱导肝癌细胞株HepG2、正常肝细胞株L02建立的肝细胞脂肪变性模型,通过检验复方蛋氨酸胆碱的防治作用,寻找简便、稳定的体外药物筛选模型。

Results The optimum preparation formulation:drug/PC:1∶30,liposomes were pH 7.4 outside and incubated at 30℃.The encapsulation rate of Vinorelbine Bitartrate in liposomes was above 85%.

结果 制备重酒石酸长春瑞滨脂质体的最佳条件是药物与磷脂的质量比为1∶30,胆固醇与磷脂质量比为1∶4,脂质体外水相pH值最终调至7.4,孵育温度为30℃,此时的包封率可以达到85%以上。

Preparation for drug serum: 20 Wistars mouses were at random divided intofour group that were fed with regular dosage baoganning (wascomposed of Milkvetch Root, Peach Seed, Baical Skullcap Root, WhitebackleafMallotus Root, Turtle Shell, Dan-Shen Root, RadixBupleuri, White Peony Root,Immature Bitter Orange,1.77g/ml),double dosage baoganning(3.54g/ml),Colchicine(0.05g/ml) and saline for seven days respectively. They were normalmouse serum,serum of baoganning regular dosage, serum of baoganning doubledosage and serum of Colchicine.

研究方法一、药物血清的制备:给正常20只Wistar大鼠随机分组,每组5只,采用血清药理学方法,分组给予保肝宁(由黄芪、桃仁、丹参、黄芩、鳖甲、柴胡、白芍、枳实等组成)等剂量煎剂(1.77g/ml),保肝宁二倍剂量组煎剂(3.54g/ml),秋水仙碱(0.05g/ml)灌胃7天,正常对照组大鼠给予生理盐水,常规方法制备含药血清及正常大鼠血清。

Although bivalency may play a role, others have observed a plateau in drug uptake with the Fab′ fragments of the human chimerized version of the antibody, albeit over a more limited range of ligand numbers.

虽然抗体的二价性可能可能在此发挥作用,但其它人还观察到在使用人嵌合抗体的Fab′片段时,纵然配体数大大超出了限界,仍然能明显提高细胞对药物的摄取。

The bivalent radical CO.Indocin is the trade name of this nonsteroidal anti-inflammatory drug.

氯苯基甲氧基甲基吲哚乙酸是一种非固醇抗炎药物的商标名称。

"Black money: Money in the economy obtained through illegal means, such as money from the drug trade."

黑钱:在经济中通过非法手段取得的金钱,如从毒品交易中获得的金钱。

However, a drug known as Gaviscon , containing magnesium carbonate and alginic acid derived from bladderwrack, has been shown helpful for heartburn in a double-blind trial.

然而,药物称为Gaviscon ,含有碳酸镁和海藻酸来自bladderwrack ,已被证明有助于灼热的双盲试验。

Other tissue content decreased largely with the exception of blind gut and large intestin at 4 hours.The total excretion of parent drug in urine and faeces was 52.4% and 6.2 % of the dose respectively.

尿和粪的排泄试验表明:尿和粪24小时以原型药物的排泄量分别占给药量的52.4%、6.2%。

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She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了,但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场,你等着挨绳子吧!

Several theories about reigniting and extinguishing of the arc have been refered.

本文综合考虑了几种电弧重燃和熄灭理论。