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Once overdose gentamicin given can cause acute renal injury in rats. The increase of Hsp70 expression at earlier period suggested that the toxic drug of kidney can cause alarm reaction in epithelial cell of nephric tubulethe.Self-protective mechanism of cells might explain it.

一次大剂量注射庆大霉素可引起急性肾损伤，在损伤的早期HSP70的表达亦显著增加，提示肾毒性药物早期即可引起肾小管上皮细胞的应激反应，可能与细胞的自我保护机制启动有关。

The effect of ARL-1 on cell growth and apoptosis induced by anticancer drug consisting of active aldehyde group were observed.

观察ARL-1基因对细胞生长的影响，和对含有活性醛基的抗肿瘤药物的细胞毒性及其所诱导的细胞凋亡的影响。

Advances on the drug development against the diabetes complications, including aldose reducta...

另外笔者还介绍了一些防治糖尿病并发症的中药和治疗对策。

The slow-release performance of these films and the factors influence the slow-release performance of films were also studied. The time that algaecide need to release out from film completely was between 20 min and 48 h, indicating all of the drug films had the slow-release property.

此外，本论文以异噻唑啉酮作为除藻剂，甲壳素、壳聚糖、聚乙烯醇等高分子材料作为载体，研究了异噻唑啉酮缓释药膜的制备、缓释性能以及各因素对其缓释性能的影响。

The structure of cell wall was not destroyed by the algaecide. So we could know: after being contacted with the algae, the algaecide could penetrate the cell wall and reacted with the protein directly, damaging the function of cell and killing the cell at last.Furthermore, we blended the isothiazolone with the high polymer, such as chitin, chitosan and poly, and prepared the slow-release drug films.

实验发现，异噻唑啉酮对棕囊藻的细胞形态结构破坏程度不大，表明了异噻唑啉酮对藻体的细胞壁、细胞膜具有很强的穿透作用，能够快速穿透细胞壁和细胞膜，与细胞内部的蛋白质作用，抑制细胞生理功能的正常发挥，导致藻体死亡。

The study drug was administered intranasally after baseline observations of modified Observer Assessment of Alertness/Sedation Scale, visual analog scale of sedation, bispectral index, visual analog scale of anxiety, pain pressure threshold measured by an electronic algometer, systolic blood pressure and diastolic blood pressure, heart rate, respiratory rate, and oxygen saturation.

在进行了基础的各项改良评估如警觉/镇痛比度表，视觉直观疼痛比度表，脑电双频指数，视觉直观焦虑比度表，电子测痛仪测得的疼痛阈，收缩压和舒张压，心率以及呼吸频率，氧饱和度后给药。

After the cold war, traditional security and nontraditional security coexisted. The nontraditional security, such as financial crisis, network information crimes, natural environmental deterioration, illegal weapon business, and aliment spread and drug trade, was very urgent. That affected world security and regional stability.

冷战后，传统安全与非传统安全并存，非传统安全凸显，从经济金融危机、网络信息犯罪、生态环境恶化到非法武器交易，以及走私贩毒和疾病蔓延，都在不同程度上威胁着全球安全和地区稳定。

These results are showed that ERCC1 is the important part of human nucleotide excision repair system, which is relevant to drug resistance of ovary and the alimentary canal tumors.

ERCC 1是人类核苷酸切除修复系统的重要组成部分，其表达水平与卵巢肿瘤、消化道肿瘤的耐药性有关。

After two to three days of usage, the diuretic effects of this drug decline because of increased downstream reabsorption of ions and water by the renal tubules; however, the alkalinization of urine persists, and this basic urine attracts weak acids such as uric acid and cystine into the urine, thus increasing their urinary excretion.

在使用两到三天之后，这种药物利尿的效果会下降由于增加了下游肾小细管离子和水再吸收；然而，坚持碱化尿，而这种基本的吸收了弱酸例如尿酸和胱氨酸到尿里，因而增加了尿的排泄

Methods: from prepation of crude drug as start, study the technology of extract and defat with L9 (3~4) orthogonal test. With EtOH extraction and water sed, alkali washing, EtOAC extraction as main methods of eliminate dopant. Finally with alky AlzO3 chromatographic column, rich and gain anticancer active site. The maximum response was achieved at a 40 min extracting time with 10 times volume 90% EtOH added to the sample for the first time and 30 min for the second time. Adding 10 times water will produce precipitation; Place the precipitation into 6 times petroleum benzin to de-fat at 60℃.

云南红豆杉中抗癌活性物制备工艺研究方法：利用正交设计试验L9(3~4)确定原料药提取工艺为：10倍量90％乙醇提取两次，第一次40分钟，第二次30分钟；醇提液用10倍量水沉；沉淀加6倍量石油醚40℃脱脂；用1mol／L的NaOH溶液碱洗，除去酸性杂质；以碱性氧化铝柱，以环己烷／丙酮为洗脱溶剂，在环己烷-丙酮(6：4)段富集到所需活性部位，洗脱剂用量为3VB。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！