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The drug design method based on the target structure is an important means to design lead drugs. Chemogenomics, the combination of combinatory library and high throughput screening accelerates the proceeding of drug research.

摘 要:基于靶标结构的药物设计方法是先导药物设计的重要手段,化学基因组学结合了组合化学和高通量筛选,加快了药物研发的进程。

Pharmaceutical manufacturers interact with regulatory agencies in developing new drug substances and new drug products, and cooperate with the compendia in writing official monographs for the compendial articles the manufacturers produce.

制药生产商和法规管理部门在开发新原料药和新药物制剂方面相互交流,并在编写由生产商生产的药典物品的官方专论方面通力合作。

Elimination of conjugative drug resistance plasmids and nonconjugative drug resistanceplasmids from 20 and 19 Shigella strains respectively by norfloxacin and berberine in vitro were analysed.

用氟哌酸和黄连素对20株携有接合传递耐药性质粒及19株携有非接合传递耐药性质粒志贺氏菌进行体外消除研究。结果显示,可被消除的耐药性质粒大多数在24小时内被消除。

The structures of drug-target complexes obtained by X-ray crystallography provide direct and convictive evidences for drug design.

利用晶体X射线衍射的方法获得药物与靶标复合物的结构,为药物设计提供最直接有力的依据。

Possible drug-drug interactions due to induction or inhibition of CYP enzymes in the small intestine are also addressed.

本文重点讨论小肠CYP450s活性与表达及其在药物代谢中的作用以及由CYP450s的诱导或抑制引起的药物相互作用。

The disposable ringed cystiform closed anal tube was used to 58 cases of analconserving operation,34 cases of sigmoid fistulation and 68 cases of blind enema and drug effusion and compared with cases of the use of single-cavity cylindrical anal tube in respect of anastomotic leakage,infection of fistula and drug effusion.

将一次性环囊肛管用于58例保肛式手术、34例乙状结肠造瘘手术及68例肛管排气及药物灌肠病人,并与应用单腔圆柱式肛管病人从吻合口瘘、吻合口狭窄、造瘘口感染、药液外溢、肛管脱出发生率方面进行比较。

Methods:The Caco-2 cell monolayer model was used to study the bi-directional transport of daphnetin and the effects of time,temperature,pH,drug concentration and P-gp inhibitor on the daphnetin absorption.Drug concentration was measured by HPLC and the apparent permeability coefficients were calculated.

采用Caco-2细胞单层模型研究祖师麻甲素的摄取和跨膜转运,采用HPLC法检测药物浓度,计算其表观渗透系数,考察时间、温度、pH值、药物浓度以及P-gp抑制剂对祖师麻甲素吸收的影响。

The rate of drug abuse in Taiwan is decreasingly amongst adolescents but drug abuse in adolescents remains certain.

青少年滥用药物的趋势虽有下降的倾向,但青少年使用非法药物的现况仍不容忽视。

RESULTS:The automatic drug dispensing system could raise the speed and accuracy of drug dispensing, improve the health condition,decrease medicine pollution,decurtate waiting time of nurse, improve the quality of pharmaceutical service.

结果:全自动口服药品摆药机可提高摆药的速度和准确性,改善卫生状况,减少药品污染,缩短护士领药时间,改善药学服务质量。

In order to understand the drug resistance mechanism of HIV-1 integrase mutually existed for multiple drug-resistant strains to the most potent IN inhibitors diketo acids, three S-1360-resistant HIV-1 strains were selected and molecular docking and molecular dynamics simulations were performed to obtain the inhibitor binding modes.

为了解DKAs引起的多种耐药株共有的耐药性机理,选择3种S-1360引起的IN耐药突变体,用分子对接和分子动力学模拟,研究了野生型和突变型IN与S-1360的结合模式,基于该结合模式探讨了3种耐药突变体所共有的耐药性机理。

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