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"Apraclonidine, a selective alpha-2-agonist, was developed to lower intraocular pressure and minimize the systemic side effects associated with the use of its parent drug, clonidine," write Patrick Watts, MBBS, MS, from the University Hospital of Wales in Cardiff, United Kingdom, and colleagues."An investigation of the site of action of apraclonidine incidentally uncovered a reversal of anisocoria in patients with absent sympathetic innervation of one pupil due to its alpha-1-effect on a pupil with denervation supersensitivity.... The easy availability of apraclonidine, its mild alpha-1-agonist activity, and its hitherto benign safety profile has encouraged its use as a first-line drug in the diagnosis of oculosympathetic paralysis."

英国加地夫市威尔斯大学附设医院的外科学硕士Patrick Watts及研究同仁指出，Apraclonidine是一种选择性的α-2-拮抗剂，是用来降低眼内压，并减少其母系药物降保适使用上的相关全身性副作用；在一项针对apraclonidine作用位置的研究中，因其单侧瞳孔神经切除之α-1-效应，而附带提出单侧瞳孔无交感神经支配患者之瞳孔大小不等为可逆转，apraclonidine之高可利用率，其轻微的α-1-拮抗活性，以及迄今良好的用药安全档案，更强化其作为视交感神经瘫痪诊断第一线药物的使用率。

OBJECTIVE To study the inhibitory effects of diterpenoid compound ( drug A.drug B) isolated from Annona glabra Linn on the proliferotion of SMMC-7721 cells lines and its mechanism .

目的 研究光叶番荔枝中二萜类化合物药A-kaur-16-en-19-oic acid、药B-kauran-19-al-17-oic acid对人肝癌细胞株SMMC-7721的抑制作用及其机理。

Antituberculosis treatment is complicated by frequent drug-interactions with highly active antiretroviral therapy and adverse drug reactions are more common among HIV-infected patients.

抗结核药物与高效抗逆转录病毒药物的副作用及时常发生的相互作用使得HIV-TB合并感染的治疗更趋复杂化。

Abstract］ Objective To study the curative effect on atrophia nervi optici treated by Chinese crude drug and meridian method.Methods Selfmade Chinese crude drug was used combined with meridian injection method and Western medicine for promoting microcirculation by mouth in order to improve activeness of cellula nervosa.

采用自制研究的中药1、2、3号活血化瘀药剂，口服改善视神经组织的微循环同时配合肝、肾俞药物注射经络调整神经细胞膜活跃性改善其传递介质的通透性。

RESULTS Among 327 specimens, cultures were positive in 320(97.9%),included 328 aerobe strains and 436 anaerobe strains.Most of the pathogenic bacteria were Gram negative.In aerobes,E.coli was the first (176 strains),while bacteroides were the first(216 strains) for anaerobes. In the positive cases, aerobic and anaerobic mixed infection were 64.7% while unitary aerobic and unitary anaerobic infection were only 25% and 10.3%, respectively.The drug sensitive rate of aerobes to the third generation cephalosporine was exceed 90%.The drug sensitive rate to metronidazole was 97.9%.

结果 32 7例标本中 32 0例有细菌生长，其中需氧菌 32 8株，厌氧菌 4 36株，以 G-菌为主；在需氧菌中以大肠埃希菌为主，占 176株；厌氧菌中以类杆菌属为主，占 2 19株；大多数为需氧菌和厌氧菌的混合感染，占 6 4 。7%；单纯需氧菌和单纯厌氧菌感染分别占 2 5 %和 10 。3%；需氧菌对第三代头孢菌素的敏感率在90 %以上，厌氧菌对甲硝唑的敏感率在 97.7%。

Drug mule （More Chinese women duped to bedrug mules--Foreign drug traffickers are duping an increasing number of Chinese women, especially young victims, into carrying drugs into China, the General Administration of Customs has said.

更多的中国妇女受骗成&毒骡&——海关总署表示，越来越多的中国妇女，特别是年轻女子，受外国毒贩的诱骗后将毒品带进中国。

Drug muleMore Chinese women duped to bedrug mules--Foreign drug traffickers are duping an increasing number of Chinese women, especially young victims, into carrying drugs into China, the General Administration of Customs (GAC has said.

更多的中国妇女受骗成&毒骡&--海关总署表示，越来越多的中国妇女，特别是年轻女子，受外国毒贩的诱骗后将毒品带进中国。

F$ p '毒骡 drug muleMore Chinese women duped to bedrug mules--Foreign drug traffickers are duping an increasing number of Chinese women, especially young victims, into carrying drugs into China, the General Administration of Customs (GAC has said.

更多的中国妇女受骗成&毒骡&——海关总署表示，越来越多的中国妇女，特别是年轻女子，受外国毒贩的诱骗后将毒品带进中国。

Clinical therapy to skin lesion could be treatedby systematic or typical application while drug concentration in skin lesion should beknown in both conditions, such as the drug concentration in blood should be knownwhen the pathogenesis of skin disease is some systematic factor.

其中药物与受体之间的亲和力由药物的结构和理化性质决定，因此靶组织的药物浓度是调节药物药效作用的主要手段。

Dialectic retinopathy,the most common microvascular complication of diabetes is the leading cause of blindness.Many drugs have been used to prevent the development of it.The primary drug treatment includes the intensive control of blood glucose,blood pressure and the reducing ofblood-fat. The directed against drug treatment includes advanced glycation end products inhibitor, vascular endothelial growth factor inhibitor,inhibitive factor promoter,supplement of inosital, aldose reductase , protein kinase C inhibitors, GH inhibitors,improvement of retinal microcirculation, DAG-PKC inhibitor, ginkgo blibe extract, antioxidant.

糖尿病视网膜病变是最常见的糖尿病微血管病变，目前有很多致力于延缓糖尿病视网膜病变的药物研究，包括严格控制血糖、血压，降低血脂的基础药物治疗，以及蛋白非酶糖基化终末产物抑制剂、血管内皮生长因子抑制剂和抑制因子促进剂、肌醇的补充及醛糖还原酶抑制剂的应用，及蛋白激酶C抑制剂、生长激素抑制素、改善视网膜微循环药物、DAG-PKC抑制剂、银杏叶提取物、抗氧化剂等针对性药物的应用。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！