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Article 100 If the drug applying for registration is in any of the following cases, it may apply for being nonprescription drug at the same time

第一百条申请注册的药品属于以下情形的，可以同时申请为非处方药

1Manufacturing or import of a nonprescription drug with existing state drug standard

已有国家药品标准的非处方药的生产或者进口

In a study of Medicare beneficiaries who were eligible for drug benefits from 1999 to 2004, Dr. Solomon's team assessed the occurrence of cardiovascular events (MI, stroke, heart failure, and cardiovascular death) in 76,082 new users of COX-2 inhibitors, 53,014 new users of nonselective NSAIDs, and 46,558 who didn't use either type of drug.

在 一个对1999至2004年适宜应用该药的医疗保险受益人的研究中，Solomon博士的团队评估了76082名新近应用了COX－2受体抑制剂，53014名新近应用了非选择性非甾体抗炎药，和46558名两类药物均没有应用的患者的心血管事件（心肌梗死，中风，心衰和心血管死亡）发生情况。

Nucleonics, Inc., a biotechnology company focused on the development of novel expressed interfering RNA based therapeutics, announced today that it has received clearance from the US Food and Drug Administration for its Investigational New Drug application to begin a Phase 1 human safety study of Nucleonics' investigational eiRNA therapy for the treatment of chronic hepatitis B infection.

nucleonics公司，该公司是一家生物技术公司，专注于开发新型表达干扰核糖核酸方法根据疗法今天宣布，它已收到了手续，由美国食品和药物管理局，其在研新药应用展开第一阶段人体安全性研究nucleonics的侦查eirna疗法治疗慢性肝炎乙感染。

Preparation of the prescription of gu yan was divided into drug granule and capsule by the primary study of preparation. Nux vomica was made into capsule according to 0.33g per granulation and the other was made into drug granule according to 15g per bag.

制剂研究初步确定"骨炎方"的制剂分为颗粒剂与胶囊剂两部分，将"骨炎方"中马钱子制成胶囊、余药按一定工艺制成颗粒剂，颗粒剂15克/袋，胶囊0.33克/粒。

The solubilities in some solvents were investigated and solubilization abilities of OCC for water-insoluble drugs were evaluated. The results show that the degree of substitution of carboxymethyl groups and octyl groups are determined to be 115.9% and 58.0%, respectively. OCC are insoluble in organic solvents while show a much better solubility in water and formed opalescence solutions, which increased the solubility of paclitaxel up to 500 folds in water. The drug loading and drug encapsulation efficiency of OCC are 34.6% and 89.9%, respectively.

所制备的OCC羧甲基取代度为115.9%，取代主要发生在6位羟基上；辛基取代度58.0%，取代主要发生在2位氨基上；与壳聚糖相比，OCC分子间／内氢键作用减弱；OCC在常用的有机溶剂中不溶，但在水中溶解度增加，能够形成具有淡蓝色乳光的纳米胶体溶液，对难溶性抗肿瘤药物紫杉醇具有优越的增溶能力，使紫杉醇在水中的溶解度提高近500倍，载药量34.6%，包封率为89.9%。

A orption rate is important because even when a drug is a orbed completely, it may be a orbed too slowly to produce a therapeutic blood level quickly enough or so rapidly that toxicity results from high drug concentratio after each dose.

吸收速率很重要。

In addition, 25 cases of ADR may be related to irrational drug use, including overhigh drug concentration (11 cases), over dose (5 cases), inappropriate choice of solvent (4 cases), and so on.

另外，25例ADR可能与不合理用药有关，包括药物浓度过高（11例）、药物剂量过大（5例）、溶媒选用不当（4例）等。

After the incubation of the parasite culture with the drug for 12h, 24h and 48h, respectively, the parasitemia was determined as an index of the drug effects.

分别作用12h，24h和48h后，检测虫体感染率的变化分析药物的作用效果。

Methods The cognitive impairment rat model was induced by hypodermic D-galactose injection and half fat feeder (6 weeks), the Morris water maze was used to screen the model rats, which were divided randomly into 4 groups (12 rats in each group): the model group, the hydrochloricdonepezil group (0.4 mg/kg, weight, sic passim), the low-dose Huannao Yicong Fang group (7 g crude drug/kg), the high-dose Huannao Yicong Fang group (14 g crude drug/kg), they were treated respectively by intragastric administration. Besides, a control group of 12 rats was set up, they were given tales doses of distilled water. After 4 weeks, the behavior of the rats was detected, the contents of plasma P-selectin and PAI-1 were measured by ELISA, also the hemorrheology was measured.

采用皮下注射D-半乳糖及喂饲半高脂饲料（6周）的方法造成大鼠认知功能障碍，Morris水迷宫行为学测试确定模型成功的动物，随机分成四组（每组12只：模型对照组给予等量水，盐酸多奈哌齐组（0.4mg/kg，体质量，下同），还脑益聪方低剂量组（7g生药／kg），还脑益聪方高剂量组（14g生药／kg），同时灌胃给药，并设立正常对照组，给予等量水。4周后，对大鼠行为学检测，应用酶联免疫法检测大鼠血浆P-选择素及PAI-1含量和血液流变学各项指标。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！