查询词典 drg

SP can affect the function of DRG neurons by activing the non-selective cation channels combining with its selective NK1 receptor. ATP depolarize DRG neurons and make some sodium channels closed so that the amplitude of action potentials and Vmax decreased which result in decreaced releasing of neurotrasmitters from DRG neurons, the way is same like GABA-induced presynaptic inhibition by activing the non-selective cation channels possibly combining with P2X2/3-receptor.

SP可能通过开放非选择性阳离子通道从而影响DRG神经元膜的兴奋性；ATP通过与P2X2/3-R结合开放非选择性阳离子通道，使得A类神经元膜预先去极化，引起膜钠通道部分关闭，动作电位幅值降低，斜率Vmax减小，使神经末梢递质释放减少，其作用与GABA介导的突触前抑制类似。

Results from whole-cell patch clamp showed: 1 BmK Ⅰ(α-like neurotoxin) was found to prolong the duration of action potential and promote the amplitude of action potential. The effects could be attributed to the selective action of BmK Ⅰ on the TTX-S Na〓 channel: slowing the inactivation process of Na〓 channel, increasing the amplitude of peak Na〓 currents; 2 BmK abT, a new-type neurotoxin with higher sequence homology to β-type scorpion neurotoxin, was found to slow the inactivation process of Na〓 channel and prolong the duration of action potential in DRG neurons.

全细胞膜片钳研究发现：1）类α型哺乳动物毒素BmK Ⅰ可延长部分DRG神经元全细胞动作电位的时程，增加动作电位的幅度，这些效应可归咎于BmK Ⅰ选择性地作用于DRG神经元TTX—S钠通道，延缓TTX—S钠电流的失活化相，峰钠电流幅度增加；2）BmK abT，一个与β型毒素同源性较高的新型蝎毒素可抑制DRG神经元全细胞钠电流失活化过程，使动作电位时程增加。

The present work was therefore designed to record single unit discharging from afferent fibers of DRG neuron, collect the interspike interval sequence of neuronal discharges, sum and analyze the rhythmic pattern of neuronal discharges, and finally perfuse the injured DRG neuron with different potassium channel blockers in order to identify the underlying dynamic rules of variations in the rhythmic patterns of neuronal discharges.

本研究从损伤DRG传入纤维中引导单根神经纤维放电，采集神经纤维放电的动作电位间期interspike interval，ISI）序列。归纳和分析神经元放电的节律形式，应用不同〓通道阻断剂灌流损伤DRG，观察神经元放电节律变化的动力学规律。主要结果如下

The present work was therefore designed to record single unit discharging from afferent fibers of DRG neuron, collect the interspike interval sequence of neuronal discharges, sum and analyze, the rhythmic pattern of neuronal discharges, and finally perfuse the injured DRG neuron with different potassium channel blockers in order to identify the underlying dynamic rules of variations in the rhythmic patterns of neuronal discharges.

归纳和分析神经元放电的节律形式，应用不同K~+通道阻断剂灌流损伤DRG，观察神经元放电节律变化的动力学规律。

And then the arthritis gradually alleviated and recovered on day 28. In addition, GAL-LI greatly rised in DRG, but decreased in laminae Ⅰ,Ⅱ of the dorsal horn following the development of polyarthritis (n=3 or 5). In the arthritic rats (n=5 or 6), EA at points could alleviate hyperalgesia and ongo- ing pain, and prevent the rats suffering from polyarthritis, meanwhile the in- crease of CGRP-, SP-and GAL-LI was reduced.Ⅱ. Expression of α-CGRP,β-CGRP and GAL mRNAs in DRG neurons of the arthritic rats and acupuncture effects

实验还观察到在动物形成变态反应性关节炎时，DRG中GAL-LI明显增加，但在背角却明显减少（n=3）；3、经电针治疗（佐剂后20天内隔天电针双环跳穴一次，持续15min）关节炎动物炎症反应减轻，同时脊髓背角和DRG中CGRP-和SP-LI的增强反应减弱，GAL-LI在DRG中的增加和在背角中减少的反应也均有所减弱，并使关节炎动物以及脊髓背角和DRG中上述递质的变化恢复加快。

Recently, it is proved that SP is also involved in pain modulation, acupuncture analgesia and immunoin- hibition. However, the role of CGRP in them is unclear Therefore, the dy- namic changes of CGRP-, SP-like immunoreactivity and expression ofα- CGRP,β-CGRP mRNAs in dorsal root ganglion and spinal cord in the arthritic rats were observed by using immunohistochemistry and in situ hybridization techniques combined with behavioral tests, respectively. Subsequently, the effects of this peoptide on the develoment of polyarthritis were investigated by intrthecal injections of CGRP and its antagonist in the rats. In addtion, GAL is a novel neuropeptide which coexists with CGRP and SP, but it may play a different role in the primary sensory system. Thus, we also observed the changes of GAL and GAL mRNA in DRG neurons and the spinal cord. The results were as follows

为此本文拟在大鼠佐剂性关节炎模型上，结合行为学测定、用免疫组织化学、原位核酸分子杂交技术观察脊髓背角及DRG中CGRP、SP、α-CGRP mRNA、β-CGRPmRNA的动态变化及电针的影响，此外，用鞘内和外周注射CGRP的工具药探讨了CGRP在佐剂性关节炎发生发展中的可能作用；甘丙肽（Galanin，GAL）也是新近发现的一个神经肽，并与CGRP和SP共存于DRG及初级传入末梢中，在神经损伤模型中脊髓CGRP、SP减少，GAL则明显增加，显示GAL与CGRP和SP的作用可能不同，因此在佐剂性关节炎模型上也同时观察了GAL和GAL mRNA的变化，实验结果如下

In the normal rats (n=5、6), CGRP-LI were mainly present in small and some medium-sized neurons and the primary afferent fibers and ter- minals in laminae Ⅰ,Ⅱ,Ⅴ,Ⅹ and Lissauer's tract of the spinal cord; GAL- and SP-LI were mainly present in small neurons and the superficial layers of the dorsal horn. After the adjuvant injection both CGRP-and SP-LI were in- creased corresponding to the development of arthritis. On day 2, CGRP-and SP-LI were moderately increased in laminae Ⅰ,Ⅱ and the posterior commis- sure of the spinal cord and small neurons in DRG, while SP was obviously in- creased in the superficial layers and DRG. On day 14, CGRP-LI were marked- ly enhanced in the above regions with the development of polyarthritis. Some- times many strongly stained long fibers could be seen in the posteriot commis- sure.

在DRG中，CGRP主要分布于小和中等神经元之中，SP和GAL主要分布于小神经元之中；2、注入弗氏完全佐剂（含冻干结核菌0.5mg）后第2天动物（各5~6例）产生具有明显红、肿、热、痛和痛敏的急性关节炎，免疫组化实验观察到注射侧脊髓背角和DRG中CGRP-和SP-LI明显增加；在佐剂后第14天，动物患肢肿胀、痛敏和自发痛均进一步加重，部分动物健肢也出现红肿，产生多发性关节炎时，脊髓背角浅层和DRG中CGRP-和SP-LI增加更为明显，并且在灰质后联合中可见许多深染的CGRP-LI长纤维；在佐剂后第21和28天，随着佐剂性关节炎的逐渐恢复，脊髓背角和DRG中CGRP-和SP-LI也接近正常。

The distribution and the number of NT-4 and IGF-I positive neurons in bilateral spared DRG (L6) in operated/acupuncture side and unoperated/acupuncture side, spinal lamina II (L3, L5, L6) and Clarke' nucleus (L3) of each animal were oberserved and counted.

结果：1.NT-4与IGF-Ⅰ在部分去背根组和针刺组备用DRG的表达变化 1.1 NT-4和IGF-Ⅰ在成年猫L_6 DRG的大、中小神经元均有表达。

under the effect of aconitine, spontaneous activity in injured drg neurons can change firing patterns.

在阻断钠通道失活门之后，受损drg神经元的自发放电可以发生模式转化，并且乌头碱对drg神经元的作用具有活动依赖性。

Electron microscope findings were compared between DRG grown in control medium containing 10% calf serum, DRG incubated in the same medium exposed to the blood compartment of capillary flow or plate dialyzers and DRG grown in medium supplemented with 10% dialysis patient serum.

对下列基质中生长的DRG的电镜发现进行比较：即DRG在含有10%牛血清的对照基质中生长、然后在暴露于毛细流血隔室或平板过滤膜（ blood compartment of capillary flow or plate dialyzers）的相同基质中孵育；DRG生长于加有10%血透病人血清的组织培养基内。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。