查询词典 doxorubicin

AIM To investigate whether dihydropyridine calcium antagonists can protect rats from nephrotoxicity induced by doxorubicin.

目的 观察二氢吡啶类钙拮抗剂对多柔比星肾毒性的影响。

After tail iv injection, the blood exposure time of stealth liposomes and the area under blood drug concentration-time curve were pronouncedly increased, compared with the regular liposomes group and the free doxorubicin group,respectively.

以化学梯度法包封脂质体，用两亲性聚乙二醇-二硬脂酰磷脂酰乙醇胺对脂质体膜进行修饰以制备隐形脂质体；用HPLC-UV法测定给药后小鼠体内组织中的药物浓度。

Ciardiello and colleagues tested ZD1839, a quinazoline derivative, in combination with cytotoxic agents that had differing mechanisms of action (cisplatin, carboplatin, oxaliplatin, paclitaxel, Taxotere, doxorubicin, etoposide, topotecan, and tomudex).

Ciardiello及其同事试验了将一种喹唑啉衍生物ZD1839与作用机制不同的细胞毒素药物（顺铂、卡铂、奥沙利铂、紫杉醇、泰索帝、阿霉素、依托泊甙、拓扑特肯等）合用。

In this thesis, we studied the effects of doxorubicin on isolated SR and intact hearts.

为深入这一领域的工作，本论文研究了阿霉素对分离SR及完整心脏的作用。

However, alkylating agents, such as cyclophosphamide, and the topoisomerase II inhibitors, doxorubicin and epirubicin, are associated with two types of cytogenetically distinct leukemias after adjuvant chemotherapy.

然而，烷化剂如环磷酰胺、拓扑异构酶II抑制剂、阿霉素、表阿霉素都与辅助化疗后的两种细胞遗传学不同的白血病的发生相关。

In this research work, the technology of microbial conversion was studied in order to establish an environment friendly method for the production of doxorubicin. A doxA gene encoding Daunorubicin C-14 hydroxylase was cloned from a daunorubicin-producing strain Streptomyces coeruleorubidus SIPI 1482. Some plasmids for the expression of doxA gene were constructed and transformed into S.

本研究对微生物转化法替代现有工艺生产阿霉素进行了探索，从柔红霉素产生菌天蓝淡红链霉菌SIPI 1482中克隆了柔红霉素C-14羟化酶基因，构建了doxA基因的链霉菌表达质粒，导入变铅青链霉菌TK24中获得了柔红霉素转化基因工程菌，并研究了doxA基因在工程菌中的表达，最后还对工程菌转化柔红霉素生成阿霉素的发酵工艺进行了初步研究。

The objective of this study was to investigate the protection by naringenin against doxorubicin-induced oxidative damage in normal blood cells.

本研究探讨柚皮素对化疗药阿霉素损伤的正常血细胞的保护作用。

It is concluded naringenin can protect against doxorubicin-induced oxidative damage in normal blood cells.

柚皮素对阿霉素损伤的正常血细胞具有保护作用，其可能机制是柚皮素提高细胞内抗氧化物酶活性同时降低氧化产物含量。

Followed two-compartment model, the biological half-life of chTNT-3-SL and (chTNT-3/B + SAv-SL) in rats was longer than that of free doxorubicin but shorter than sterically stabilized liposomes.

结果表明，两种主动靶向脂质体给药系统与固定Raji细胞的结合量均显著高于阴性对照组(P＜0.001)。

METHODS: Collaborative meta-analyses were undertaken of 194 unconfounded randomised trials of adjuvant chemotherapy or hormonal therapy that began by 1995. Many trials involved CMF (cyclophosphamide, methotrexate, fluorouracil), anthracycline-based combinations such as FAC (fluorouracil, doxorubicin, cyclophosphamide) or FEC (fluorouracil, epirubicin, cyclophosphamide), tamoxifen, or ovarian suppression: none involved taxanes, trastuzumab, raloxifene, or modern aromatase inhibitors.

对194个开始于1995年的关于辅助化疗或激素治疗的随机试验进行meta分析，许多试验包含了CMF(环磷酰胺、氨甲喋呤、氟尿嘧啶)，蒽环药物为基础的联合化疗比如FAC(氟尿嘧啶、阿霉素、环磷酰胺)或FEC（氟尿嘧啶、表阿霉素、环磷酰胺）及他莫昔芬或卵巢去势；无一包含紫杉烷类、赫赛汀、雷洛昔芬及芳香化酶抑制剂。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。