查询词典 dox

The resultsshowed that CAs and CaMAs could both enhance the intracellularDoxorubcine level and decrease the membrane P-Gp expression of K562/VCRcells,indicating there existed significant difference with the control group(P＜0.01).And the changes of the intracellular Doxorubcine concentrationinduced with CAs and CaMAs had positive dose-responses relationship withCAs and CaMAs concentration in K562/VCR cells(P＜0.01),while thechanges of membrane P-Gp expression had no dose-responses relationshipwith CAs and CaMAs concentration in K562/VCR cells.

结果表明：CAs或CaMAs既能提高K562/VCR细胞内Dox的浓度，又能降低K562/VCR细胞膜P-Gp的表达，与对照组相比，存在着明显差异（P＜0.01）；CAs和CaMAs各浓度间引起的K562/VCR细胞内Dox浓度的变化也存在着明显的差异（P＜0.01），呈正的量效关系；但CAs和CaMAs各浓度间引起的P-Gp表达的变化无明显差异。

And the interaction mechanism of DOX with malignant hepatocytes and side-effect of DOX to the normal hepatocytes were studied.

研究了药物与肿瘤肝细胞的作用机制和对正常肝细胞的毒副作用。

The concentration of DOX in tumor and the apoptotic rate in cancer cell were all higher in DOX plus CWQ group than that in other groups.

结果 阿霉素和肠胃清单独给药均不能抑制肿瘤组织的生长，阿霉素与肠胃清联合能显著减少肿瘤组织的重量，增加肿瘤组织内的阿霉素浓度，诱导肿瘤细胞发生凋亡。

WE CAN DO 40 FCL OUT OF CHINA CLEAR CUSTOMS AS GLOVES, COMPUTER PARTS, ONCE IT IS CLEAR ALREADY AT THE AIRPORT WE CHANGE DOX WITH REAL DESCRIPTION .

我们想要一个40尺柜的当做手套和电脑配件产品通过中国海关，一旦它在机场的清关结束，我们就会和真实的货名用DOX对调

The results indicate that A54 can improve the cytotoxicity of DOX to malignant hepatocytes and decrease the side-effect of DOX to normal hepatocytes.

实验结果表明A54能够提高阿霉素对肿瘤细胞的毒性并降低对正常肝细胞的毒副作用。

Results DOX pre-conditioning and IP significantly decreased serum AST,ALT and LDH,furthermore interaction of DOX preconditioning and IP had statistical significance and associating application of the two methods decrease serum AST,ALT and LDH to a lower level.IP significantly decreased plasma ET and serum TNF-α;DOX and IP significantly increased serum NO;DOX preconditioning improved the expression of HSP70in liver.

结果 阿霉素预处理、缺血预处理、阿霉素+缺血联合预处理能明显抑制AST、ALT、LDH水平升高，其中以阿霉素+缺血联合预处理作用最显著；缺血预处理能显著降低ET、TNF-α水平；阿霉素预处理和缺血预处理使NO显著升高；阿霉素预处理能使肝细胞HSP70显著增加。

Methods:Doxorubincin-resistant human hepatoma cell subline (HepG2/DOX) was induced by doxorubincin-gradually increasing concentration.

以浓度梯度递增方法，用DOX诱导HepG2产生耐药性。

Preinduction of MT by zinc protects the heart from DOX-induced cardiotoxicity, and this effect is possibly correlated with the property of MT on scavenging free radicals in vivo.

Zn诱导MT表达对DOX心脏毒性具有明显的保护作用，其机制可能与MT体内清除自由基功能有关。

①Rat MSC and VSMC were cultured and identified, respectively. MSC were labeled with DAPI firstly, and then co-cultivated with VSMC. The changes of morphology and ultrastructure of co-cultured cells were observed. Immunfluorescence analysis was performed by using monoclonal antibodies against specific antigen.②We established the regulatable system in two steps: a stable MSC line expressing rtTA has been constructed and characterized firstly by transfected with pUHD 17-1hyg and then selected by hygromycin B; in a second step, this line was used for trandfer the AT2R gene to MSC to get the well establishing double stable MSC lines;③The expression of AT2R regulated by doxycycline was evaluated by western blot;④The MSCs were transduced into rat carotid arteries with regulatable AT2R gene after the establishment of rat carotid balloon injury restenosis model. The intimal/medial area ratio were measured by digital analysis system.

研究方法：(1)密度梯度离心法及胶原酶消化法分别培养原代大鼠MSC及VSMC，细胞共培养并行免疫荧光化学染色和透射电镜观察超微结构；(2)组成受Dox调控的哺乳动物表达系统的四种成分的转化、扩增及提纯并酶切鉴定；(3)采用常规分子生物学方法连续两个回合转染体外培养的MSC，并分别采用发光计检测不同细胞克隆萤光素酶活性改变以及RT-PCR方法检测AT2R目的基因mRNA表达情况，根据各个细胞克隆受Dox调控表达的程度，选择低背景、高诱导表达AT2R的细胞系，作为双重稳定MSC细胞系；蛋白免疫印迹法观察该细胞系在Dox调控下AT2R表达的时相性、持续性及在不同浓度Dox调控下的表达情况；(4)建立大鼠颈动脉球囊损伤动物模型，将双重稳定MSC在术中导入血管，分别于14 d、28 d进行病理切片，检测可调控AT2R对新生内膜增生的影响；采用RT-PCR免疫组织化学免疫荧光等技术观察AT2R基因在新生内膜中的表达以及细胞外基质成分表达的改变，TUNEL法检测血管组织中细胞凋亡的变化情况。

LC3-FITC had been used to monitor autophagy by immunofluorescence. It showed that there are a high level of LC3 puncta in HCQ+DOX or BAF +DOX treated cells, and in rapamycin treated cells, moderate level in HCQ, BAF, or DOX singly treated cells, and low level in 3-MA+DOX, and there was diffuse fluorescence in untreated or 3-MA treated cells.

内源性LC3免疫荧光染色显示，羟氯喹+阿霉素、BAF+阿霉素及雷帕霉素处理组MM细胞胞浆可见大量颗粒状荧光，羟氯喹、BAF、阿霉素单用组仅有中等量颗粒状荧光，而3-MA及3-MA+阿霉素组胞浆荧光信号基本呈弥散分布，类似于未处理对照组。5。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。