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RESULTS The proliferation of fibroblasts was inhibited by K102 in vitro. A dose-dependent antagonistic effect was found between K102 and bFGF. The serum levels of ALT, AST and the liver hydroxyproline level in the treated groups were lower than that in the CCl4 model group. Pathological examination showed a slight fatty degeneration and hydropic degeneration was observed in the group treated with the high dose K102, the low dose K102, and the control group.

结果体外生物活性检测：K102明显抑制成纤维细胞的生长，bFGF对K102有一定拮抗作用，且具有剂量依赖性；体内生物活性检测：治疗给药组血清ALT，AST和肝组织羟脯氨酸含量较CCl4模型组明显改善。

Methods: Gastric cancer model of nude mice were established by transplanting human gastric cancer cell line (BGC-823) into hypoderm at right armpit, and then the cancer-beating mice were divided randomly into 5 groups: model group, cyclophosphamide group, and 3 Ad treated groups (high-dose, middle-dose, and low-dose groups).

将人胃癌细胞BGC-823接种于裸鼠右侧腋皮下，建立荷瘤裸鼠模型。

If the expected positions of the minimum and maximum dose are known from a previous irradiator performance characterisation, some dosimeters could be removed from regions of average dose and replaced to form a 10 cm grid in the regions of extreme dose.

如果从先前的辐照器的特征试验得到各测量位置的最大剂量和最小剂量，一些辐射量测定器可从平均剂量的区域处移走并能在极端剂量区域里放置排列成一个10厘米格子。

The conventional dose, 3 times the dose kelp and Prunella are caused by iodine deficiency in rats hyperthyroidism, conventional doses of kelp with the dose increased the degree of severe hyperthyroidism, Prunella laminarin compared with hyperthyroidism minor.

常规剂量、3倍剂量昆布和夏枯草均致碘缺乏大鼠甲状腺功能亢进，常规剂量昆布随着剂量增加甲亢程度严重，夏枯草与昆布相比甲亢程度轻微。

The method uses tall fat emulsion to build bandicoot tall lipemia model of sexual fatty liver, experimental cent is group of high dose of drink of fat of regular set, model group, disappear and small dose group, treasure liver peaceful is electropositive group to the south of, with drink of fat of disappear of tall, small dose peaceful of He Dongbao liver undertakes intervention, determine branch content exceeds to cross oxide in liver fat content and liver enzymatic active, third 2 aldehyde content and vitamin E level.

方法采用高脂乳剂建立大鼠高脂血症性脂肪肝模型，实验分为正常组、模型组、消脂饮高剂量组和低剂量组，以东宝肝泰为阳性组，以高、低剂量消脂饮和东宝肝泰进行干预，测定肝脂含量及肝中超歧物过氧化物酶活性、丙二醛含量和维生素E水平。

In order to observe the effects of mercuric chloride to physiological and biochemical indexes of blood at low doses in SD rats, 24 SD rats were separated into control group, low dose group of mercury (50 mg/L), middle dose group of mercury (100 mg/L), high dose group of mercury (200 mg/L), which were given in the drinking water.

为了研究低剂量汞对SD大鼠血液生理生化指标的影响，24只SD大鼠被随机分为4组，分别为对照组，汞低剂量组（50 mg/L），汞中剂量组（100 mg/L），汞高剂量组（200 mg/L），采用自由饮水染毒，染毒时间为21d。

Results ①Compared to sham group, ISH and IHC of rat hypothalamic CRHshow positive cells numbers increase, positive areas enlarge and average gray scaledecreases, which reveals the expression of hypothalamic CRH neurons enhances afterPX;②The enhancement of ISH and IHC of hypothalamic CRH in PX rats aftermelatonin supplementation dose-dependently recovers, but it can't return to be normaleither in high dose group or in low dose group and either at 4th week or at 8th week;③IHC of CRH in median eminence of neurohypophysis shows positive areas enlargeand average gray scale decreases, which reveals the releasing of CRH fromhypothalamic CRH neurons increases;④ELISA of CRH in serum shows thedifferences of CRH concentrations among all groups are not significant, which indicates PX and melatonin supplementation have no significant effect on CRH levels.

结果： ①松果体摘除后大鼠下丘脑室旁核CRH 原位杂交和免疫组化的结果与假手术对照组相比均显示阳性细胞数增多、阳性面积增加、平均灰度降低，提示松果体摘除后下丘脑CRH 神经元的表达增强；②松果体摘除大鼠补充褪黑素后，下丘脑CRH 原位杂交和免疫组化染色增强呈剂量依赖性恢复，不过不论是低剂量组还是高剂量组，也不论是术后4 周还是术后8周，均不能恢复至正常；③松果体摘除后神经垂体正中隆起CRH 免疫组化结果显示阳性面积增加、平均灰度降低，提示下丘脑CRH 神经元释放CRH 增加；④ELISA 法检测血清CRH结果示各组血清CRH 浓度差异没有显著性，表明松果体摘除及补充褪黑素对血清CRH 水平没有显著影响。

Results ①Compared to sham group, ISH and IHC of rat hypothalamic CRHshow positive cells numbers increase, positive areas enlarge and average gray scaledecreases, which reveals the expression of hypothalamic CRH neurons enhances afterPX;②The enhancement of ISH and IHC of hypothalamic CRH in PX rats aftermelatonin supplementation dose-dependently recovers, but it can't return to be normaleither in high dose group or in low dose group and either at 4th week or at 8th week;③IHC of CRH in median eminence of neurohypophysis shows positive areas enlargeand average gray scale decreases, which reveals the releasing of CRH fromhypothalamic CRH neurons increases;④ELISA of CRH in serum shows thedifferences of CRH concentrations among all groups are not significant, whichindicates PX and melatonin supplementation have no significant effect on CRH levels.

结果： ①松果体摘除后大鼠下丘脑室旁核CRH 原位杂交和免疫组化的结果与假手术对照组相比均显示阳性细胞数增多、阳性面积增加、平均灰度降低，提示松果体摘除后下丘脑CRH 神经元的表达增强；②松果体摘除大鼠补充褪黑素后，下丘脑CRH 原位杂交和免疫组化染色增强呈剂量依赖性恢复，不过不论是低剂量组还是高剂量组，也不论是术后4 周还是术后8周，均不能恢复至正常；③松果体摘除后神经垂体正中隆起CRH 免疫组化结果显示阳性面积增加、平均灰度降低，提示下丘脑CRH 神经元释放CRH 增加；④ELISA 法检测血清CRH结果示各组血清CRH 浓度差异没有显著性，表明松果体摘除及补充褪黑素对血清CRH 水平没有显著影响。

Accuracy between two groups was calculated byχ~2 test.Calculate the average effective radiation dose of the 30 patients.Results In group A,seventeen patients underwent both DSCT coronary angiography and SCAG,among 255 segments of 17 patients,105 lesion sites of 70 segments were diagnosed stenosis or obstruction,of them,95 lesion sites were confirmed by SCAG.The accuracy of DSCTCA was 90.48%.The agreement of two methods have a high agreement(Kappa =0.853).In group B,13 patients underwent both DSCT coronary angiography and SCAG,among 195 segments of 13 patients,73 lesion sites of 57 segments were diagnosed stenosis or obstruction, of them,65 lesion sites were confirmed by SCAG.The accuracy of DSCTCA was 89.04%.The agreement of two methods have a high agreement(Kappa =0.835). There was no significant difference(χ~2=0.098,p＞0.05) between the accuracy of two groups.The effective radiation dose of 30 patients was 3.67±0.43 mSv.Conclusion Compared with SCAG,prospectively ECG-gated transverse DSCT is a valuable examination to detect and diagnose coronary artery disease with a low dose coronary angiography.The accuracy of the DSCT is approximate to the SCAG.There was no significant difference between the accuracy of two groups.

结果200例患者均成功完成了适应性前瞻性心电门控双源CT冠状动脉血管成像；30例同期行SCAG检查的患者，A组17例：HR≤75 bpm，可评价冠状动脉节段255个，70个冠状动脉节段有105处不同程度的狭窄，95处狭窄程度与金标准SCAG相符，其阳性诊断准确率为90.48%；2种方法的诊断结果得到了较高的一致性(Kappa值=0.853)。B组13例；HR≥91 bpm，可评价冠状动脉节段195个，57个冠状动脉节段有73处不同程度的狭窄，65处狭窄程度与SCAG相符，其阳性诊断准确率为89.04%；2种方法的诊断结果得到了较高的一致性(Kappa值=0.835)。2个心率组间的诊断准确率无明显统计学差异(x~2=0.098，p＞0.05)。30例患者的平均有效辐射剂量为3.67±0.43 mSv结论适应性前瞻性心电门控双源CT冠状动脉成像是一种有效减低辐射剂量的扫描方式，其诊断准确率与金标准SCAG相比得到较高的一致性，且高、低2个心率组间诊断准确率无明显统计学差异。

The results showed that the population administered with free adjuvant cholera vaccines,both low dose group and common dose group,occurred the weak adverse reaction with 10￣25% rate.The reaction rates between two dose groups of the same vaccine have not significant difference;The reaction rate of the first inoculation(19￣25%) is higher than those of the second inoculation(10￣15%)(P 05);The inoculating local reaction is very light ,only the very few subject occurred the scleroma with 15 mm of diameter.The reaction of aluminum absorbed cholera vaccine is slightly stronger than those of other groups.

结果表明，不加铝佐剂的O139型霍乱菌苗及O1群霍乱菌苗，不论是低剂量组（两剂全程接种45亿菌体）抑或常剂量组（全程接种90亿）接种人群均可产生10～25％的体温呈轻度升高的弱反应，并且同种菌苗的两剂量组的反应率无显著差异；第一剂接种的反应率（19～25％）较第二剂接种的（10～15％）高，P＜0.05；接种局部反应轻微，只有个别受试者出现直径小于15mm的硬结；加佐剂的O1群吸附霍乱菌苗的反应较其它组强。

Were used by medieval physicians...

被中世纪的医师用来。。。

Article 19 Where the shareholders of a limited liability company or the directors and controlling shareholders of a joint stock company or the actual controllers of a company maliciously dispose of company properties and thus cause losses to any creditors after the company dissolution, or fail to make liquidation and cheat the company registration organ to deregister the legal person by means of a false liquidation report, if any creditors claim that the aforesaid shareholders, directors and controlling shareholders or actual controllers shall assume the corresponding civil liability for the debts of the company, the people' s court shall support the claim.

第十九条有限责任公司的股东、股份有限公司的董事和控股股东，以及公司的实际控制人在公司解散后，恶意处置公司财产给债权人造成损失，或者未经依法清算，以虚假的清算报告骗取公司登记机关办理法人注销登记，债权人主张其对公司债务承担相应赔偿责任的，人民法院应依法予以支持。