查询词典 dose rate

In a 2-week, double-blind, placebo-controlled study of 186 people with intermittent allergic rhinitis, use of butterbur at a dose of three standardized tablets daily, or one tablet daily, reduced allergy symptoms as compared to placebo.34 Significantly greater benefits were seen in the higher dose group.

在为期2周的，对186名患有间歇性过敏性鼻炎患者进行安慰剂控制的双盲研究中，分别给患者服用每天3片和每天1片的剂量，将结果与安慰剂试验进行比较，高剂量能明显减轻过敏症状，2个剂量的不同肯定了这种治疗是有效的。

The resultsshowed that CAs and CaMAs could both enhance the intracellularDoxorubcine level and decrease the membrane P-Gp expression of K562/VCRcells,indicating there existed significant difference with the control group(P＜0.01).And the changes of the intracellular Doxorubcine concentrationinduced with CAs and CaMAs had positive dose-responses relationship withCAs and CaMAs concentration in K562/VCR cells(P＜0.01),while thechanges of membrane P-Gp expression had no dose-responses relationshipwith CAs and CaMAs concentration in K562/VCR cells.

结果表明：CAs或CaMAs既能提高K562/VCR细胞内Dox的浓度，又能降低K562/VCR细胞膜P-Gp的表达，与对照组相比，存在着明显差异（P＜0.01）；CAs和CaMAs各浓度间引起的K562/VCR细胞内Dox浓度的变化也存在着明显的差异（P＜0.01），呈正的量效关系；但CAs和CaMAs各浓度间引起的P-Gp表达的变化无明显差异。

Except for 2μmol/L Verapamil,other concentrations ofCAs and CaMAs could decrease mdr1 mRNA expression level of K562/VCRcells,indicating significant difference from those of control group(CAs:P＜0.05;CaMAs:P＜0.01),but the changes of mdr1 mRNA expression levelcaused by CaMAs had negative dose-responses relationship with CaMAsconcentration(P＜0.05),while the changes of mdr1 mRNA expression levelinduced with CAs had no dose-responses relationship with the CAsconcentration.

除〓的Ver外，其它浓度的CAs和CaMAs均可降低K562/VCR细胞mdr1 mRNA表达水平，与对照组相比，存在着明显差异（CAs：P＜0.05；CaMAs：P＜0.01）；并且CaMAs各浓度间引起的mdr1 mRNA表达水平的变化也存在着差异（P＜0.05），呈负的量效关系，而CAs各浓度间引起的mdr1 mRNA表达水平的变化无明显差异。

Methods :Sixty patients with CHF were randomly divided into routine therapy group(control group,n=18),which were administered cardiotonic,diuretic and vascellum expander;low dose atorvastatin group (n=20)and high dose atorvastatin group (n=22),which were supplemented by atorvastatin 10mg/day and 40mg/day separately, besides the routine therapy for 8 weeks.

60例CHF患者分为3组，对照组(n=18)常规予强心、利尿和血管扩张剂治疗，小剂量阿托伐他汀组(n=20)在前者基础上加用阿托伐他汀片(10mg/d)，大剂量阿托伐他汀组(n=22)则在基础治疗上加用阿托伐他汀片(40mg/d)，各治疗8周。

Pae (25-100mg/kg, ip) not only inhibited the swelling of mouse pinnea induced by xylene in a dose-dependant manner, but also suppressed the edema of rat hind paw induced by injection of 1% carrageenin at a higher dose (100 mg/kg, ip).

Pae(25-100mg/kg，ip)可剂量依赖性地抑制二甲苯所致的小鼠耳肿胀，高剂量(100mg/kg，ip)时可抑制角叉菜胶所致的大鼠足跖肿胀。

A new study just published in the International Journal of Cancer examined the activity of chlorophyllin and found that, on a dose-by-dose basis , it was 10 times more potent at causing death of colon cancer cells than hydroxyurea, a chemotherapeutic drug commonly used in cancer treatment.

根据国际癌症杂志的一项对叶绿酸的活性研究，发现同等剂量下，它比常用的化疗药物羟基脲在杀死结肠癌细胞的作用要强10倍。

The expression level of metabolitic enzyme (CYP1A1, CYP1B1) and its correlation with cell differentiation /apoptosis were studied as well. The influence of resveratrol in cell cycle was determined with FCM. Results 1 Resveratrol not only suppresses the growth of medulloblastoma cells in a dose and time related fashion but also induces cell differentiation and apoptosis. Resveratrol promotes differention of UW228-1,-2 cells to forward glia, UW228-3 and Med-3 cells to neuron. A treatment of resveratrol in the concentration of 100μM for 48hrs comit most of cells die of apoptosis. 2 Among the four cell lines Fas and Caspase-3 were constantly expessed, whereas FasL was absent irrespective to the drug treatment. 3 ICC, RT-PCR, Western-blot hybridization and EROD enzymatic activity assay demonstrated that expression of CYP1A1 is different after treatment with resveratrol in four cell lines, up-regulated in three UW228 cell lines in a dose dependent manner but down-regulated in Med-3 cells. Suppressive effect of resveratrol on CYP1B1 expression is the same among four medulloblatoma cell lines. 4 Cell cycle distribution of UW228-3 was greatly changed after treatment.

结果：1、白藜芦醇以时间和剂量依赖性方式抑制髓母细胞瘤细胞生长，同时促进细胞的分化和凋亡：白藜芦醇促使UW228-1、-2靶细胞向神经胶质细胞方向成熟分化，UW228-3、Med-3细胞向神经元细胞方向成熟分化，以100μM作用48小时效果显著；2、四个细胞系均有Fas和Caspase-3表达，但无Fas-L基因表达和蛋白活性产生，因此难以形成Fas相关性死亡通路；3、白藜芦醇处理前后CYP1A1基因的表达在各细胞系略有不同：UW228-1，-2，-3三个细胞系白藜芦醇以剂量相关性方式上调CYP1A1的表达，而Med-3细胞系，白藜芦醇却抑制CYP1A1的表达；四个细胞系在白藜芦醇处理后CYP1B1的表达均受到抑制；4、UW228-3细胞系经白藜芦醇作用后细胞周期有较大改变，表现在G0/G1期在整个细胞周期中所占的比例增加，而其它时期则相应减少。

Days after a convulsant dose of KA, the seizure susceptibility were found in KA+NS group and enhanced in KA+PL017 group, whereas significantly decreased in KA+β-FNA group (p.01).β-FNA prolonged the latency and reduced the stage of seizures in dose-dependent manner.

结果显示，一次给予惊厥剂量KA后7天，KA+NS组的癫癎发作敏感性形成；MORs激动剂组（KA+PL017）动物出现癫癎发作敏感性增强；与上述两组比较，MORs拮抗剂组动物癫癎发作敏感性明显降低（p.01），β-FNA以剂量依赖方式延长癫癎发作的潜伏期、降低发作级别。

The seizure sensitive rats were made by subcutaneous injection of a convulsant dose (10mg/kg) of KA. Normal saline , PL017 or β-FNA were infused constantly into ventral hippocampus of awakened and freely moving animals for 7 days by mini-osmotic pumps. 7 days later, all rats were given subcutaneously with subconvulsant dose of KA.

皮下注射惊厥剂量（10mg/kg）的KA制备颞叶癫癎模型的癫癎发作敏感大鼠，采用微渗透泵技术分别将生理盐水、PL017和β-FNA连续7天恒速注入清醒自由活动的上述动物的腹侧海马内。7天后皮下注射阈下剂量（5mg/kg）KA检测癫癎发作敏感性形成情况。

Among the 6 recurrent cases, one had new coronary artery lesions; three had expanding coronary artery lesions. Among the 3 cases that recurred within 2 months, IVGG and ASA had not been used in one case, and ASA was reduced to low dose just 3 days after defervescence in 2 cases. The cases that recurred within 2 months were more likely to occur in which ASA was reduced to low dose just 3 days after defervescence than those in which gradually.

再发病例6例，其中1例有新的冠状动脉损害形成，3例原有冠状动脉损害加重。3例在初发病2月内再发者，其中1例未用IVGG及ASA治疗，2例热退后ASA快速减量。

In the days of sailing vessels the crew were afraid they would be becalmed on the ocean.

在使用帆船的时代，船员们担心他们会因为无风而无法在海洋上航行。

As long as foreign donors pay the PA's salary bill, few expect a new intifada.

只要外国继续为巴权力机构的薪水买单，希望发动新暴动的人便寥寥无几。