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Ten dosages of La2O3 , 10, 20, 30, 40, 50, 60, 100, 150, 200 and 300 mg of La2O3 in 1 kg of wheat bran was used. Newly eclosion larvae and adults were continuously reared in the La2O3 food with different dosages.

用40mg氧化镧/kg麦麸的剂量处理79d后幼虫体重比对照组增加43%,同样的剂量使产卵高峰期的雌虫日平均产卵量增加59%,是最佳的处理剂量。

objective compare the ill effect and valence of analgesia of morphia with the same dosages and 1.5 times dosages of tramadol after the thoracotomy.

目的 比较与吗啡等效剂量及1.5倍等效剂量的曲马多,用于开胸术后pcia的镇痛效价与副作用。

The group disposed by Acetylspiramycin doesn"t show parallel results; The strip gray scale of exotoxin A decreased gradually with the increasing dosages of Azithromycin and Roxithromycin, which doesn"t show in group disposed by Acetylspiramycin and group PAO-JP2; The strip gray scale of lasR, detected by RT-PCR, decreased gradually with the increasing dosages of Azithromycin, which doesnt show in group PAO-JP2.Conclusions: There were obvious differences between PAO1 and PAO-JP2 in biology characteristics in vitro.

本研究发现大环内酯类药物在生物被膜培养过程中分别处理PAO1、PAO-JP2,结果提示大环内酯类药物(14、15元环)通过对QS系统的影响可有效抑制铜绿假单胞菌生物被膜的形成;通过QS系统有效抑制铜绿假单胞菌的毒力因子的产生,16元环的大环内酯类药物乙酰螺旋霉未见上述结论;lasR基因的反转录结果提示阿奇霉素可在转录水平抑制QS系统发挥其作用。

ERαhad a weaker expression inraloxifene of 1mg/kg/d with estradiol valerate of 0.02mg/kg/d group than the othergroups 1 Raloxifene combined with different estradiol dosages hasdemonstrated the same protecting effect on bone as raloxifene alone. Combinedadministration does not decrease the protecting effect. 2 Raloxifene combined with different estradiol dosages has not demonstratedstimulatory effect on uteri and breasts and has maintained normal aorta structure.

1雷洛昔芬和不同剂量雌激素配伍对去卵巢大鼠的股骨效应与雷洛昔芬相同,两种药物合用不减弱对骨的保护作用。2雷洛昔芬和不同剂量雌激素配伍对去卵巢大鼠的子宫和乳腺无刺激性,能够维持主动脉内皮和平滑肌的正常形态和功能。

Methods The experimental arrhythmia models were induced with barium chloride (BaCl2),uabaina and aconitine in rats and cobayaes.The incidence rate and mortality rate of arrhythmia,the emergence time and the duration of arrhythmia induced with BaCl2 were recorded in rats pretreated with CASI (in dosages of 25,50, and 100 mg·kg-1 sublingual vein injection).At the same time,the dosages of uabaina and aconitine were observed when the ventricular premature contraction,ventricular tachycardia,ventricular fibrillation and cardiac asystole were appeard in rats and cobayaes pretreated with CASI (in dosages of 25,50, and 100 mg·kg-1 sublingual vein injection).

制备氯化钡(BaCl2)、哇巴因及乌头碱诱导的大鼠及豚鼠实验性心律失常模型,CASI按25、50、100 mg·kg-1分为3个剂量组,舌下静脉给药1次,不给CASI作为对照组,记录大鼠给BaCl2后心律失常的发生率、出现时间、持续时间及动物的死亡率;观察豚鼠及大鼠出现室性早搏、室性心动过速、心室颤动及心脏停搏时哇巴因及乌头碱的用量。

Observe all the patients ingested dosage, treatment time after poisoning, cholinesterase activity on admission and the mortality; Observe the survived patients' duration of the recovery of CHE activity, the time interval to achieve atropinization from admission, the cumulative dosages of atropine to achieve atropinization, the cumulative dosages of atropine in the hospital and the incidence of intermediate syndrome.

观察全部病例的服用量,首诊时间,初诊时胆碱酯酶活力和死亡率,存活病例的CHE恢复时间,达阿托品化的时间,阿托品化的阿托品用量,病程中阿托品的总量及中间综合徵发生率。

Results: Tyroserleutide can significantly increase the life span of H22 tumor-bearing mice by 50-70% in dosages of 20ug/kg/d-80ug/kg/d,specially the high dosage of 80ug/ml can significantly increase the life span by 69.24%; Tyroserleutide can inhibit the growth of transplanted hepatocellular tumor BEL-7402 in nude mice,the rate of tumor inhibition was25-50% in dosages of 40-320ug/ml ,the inhibition rate of 160ng/ml was 44.03%; Tyroserleutide could inhibit the growth of H22 and BEL-7402 tumor in a dose-dependent manner. Simultaneously, tumoricidal activity of tyroserleutide against BEL-7402 cell line in vitro was observed hinger when compared with the control group(P.05).The inhibition effect of 72hrs was higher than 24hrs,48hrs,96hrs.And specially the high dosage of 160ug/ml can significantly inhibit growth of tumor cell by 19.36%. Tyroserleutide can activated PEM and marked enhance cytotoxicity andphagocytosis functions in vitro and in vivo. The OD values of cytotoxicity were observed hinger when compared with the control group(P.05).The cytotoxicity of macrophages activated by tyroserleutide against BEL-7402 and B16-F10 was 35.58%,61.2% in vitro and21.39%,47.63% in vivo. The cytotoxicity rate of nude mice PEM was 32.86%,73.07% in vivo. Furthermore, tyroserleutide alone could stimulated the production of IL-1B TNF- a and NO by M . Tyroserleutide and LPS could synergistically activated M producing more cytotoxicity effectors. Conclusion: Tyroserleutide had inhibition functions against hepatoma carcinoma .Its possible mechanisms were related to the affect that Tyroserleutide could inhibit tumor cell directively and induce tumor cells apoptosis or death effectively.

结果:酪丝亮肽能显著延长腹水型肝癌H_(22)小鼠的生存时间,给药剂量为80μg/kg/d时疗效最显著,达到69.24%,在20μg/kg/d-80μg/kg/d剂量范围内生命延长率为50-70%,给药剂量与荷瘤鼠生存时间呈现一定量效关系;酪丝亮肽能显著抑制人肝癌BEL-7402移植瘤裸鼠的肿瘤生长,给药剂量为160μg/kg/d时疗效最显著,抑制率为44.03%,并且在40-320μg/kg/d剂量范围内抑制率为25-50%,给药剂量与肿瘤抑制率呈现一定量效关系;酪丝亮肽体外对人肝癌BEL-7402细胞生长有一定的抑制作用,在作用72hrs时各浓度酪丝亮肽对肿瘤细胞的抑制作用较24hrs、48hrs、96hrs明显,其中浓度为100μg/ml时抑制率达19.36%;酪丝亮肽体内外均能增强小鼠腹腔巨噬细胞对肿瘤细胞的杀伤:体外作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强,与效应细胞对照组相比有显著性差异(P<0.05)杀伤率分别达到35.58%、61.2%;体内作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强,与生理盐水对照组相比有显著性差异(P 。05),杀伤率分别达到21.39%、47.63%;裸鼠腹腔巨噬细胞经酪丝亮肤作用后对BEL一7402、B 16一F10杀伤功能明显增强,与生理盐水对照组相比有显著性差异(P.05),最高杀伤率分别达到32.86%、73.07%;酪丝亮肤能增强单核巨噬细胞系统的吞噬功能,吞噬指数与生理盐水组比较有显著性差异(P.05);酪丝亮肤体外作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO,与效应细胞对照组相比有显著性差异(P.05);酪丝亮肤体内作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO,与生理盐水对照组相比有显著性差异(P.05);酪丝亮肤能促进鼠巨噬细胞株R戌W264.7分泌合成IL一1p和NO,IL一1日、NO水平分别在酪丝亮肤作用24hrs、12hrs时达到高峰,酪丝亮肤单独应用能提高巨噬细胞的分泌合成功能,而且酪丝亮肤能与LPS协同作用刺激巨噬细胞的细胞毒效应分子分泌合成。

During using anaerobic fermentation slurry as insecticide, there had many problems that are random using, non-strictly prevention and curing time, non-suitable temperature and consistency mixture ratio ctc. In this research, fristly the different mixtures are made according to the different ratio of slurry to additive. Then the insecticidal effects of the mixture are tested in different conditions so as to find the good matches of slurry and additive in laboratory. According to the up result of the good matches extents of mixture, the field experiment is made to test the mixture's insecticidal chraricter and is further found new dosage form which has many good indexes such as good insecticidal effectiveness, little additive dosis ctc. So as to looking for the dosage form's synergism, the significant analysis is done and the characters of the dosages are tested which are ecological and environmental and the new types of dosage are determined. At last, for proving the dosage's field insecticidal potency, the wide field area experiments are done and four new style dosages are triturated which adapt ecological agriculture development. Aadditionally the effective period of the mixtures are tested when other experiments are done.

本文针对厌氧发酵液作为杀虫剂施用时,随用即配和无严格的增效剂种类、喷施时间及温度、浓度配比等现象,首先对各添加剂与厌氧发酵液配成的不同浓度的混和剂在不同条件下进行实验室测试,确定杀虫率高的浓度范围,进一步细化各混和剂浓度范围作田间试验,选出杀虫效果好,添加剂量少等各项指标都好的剂型并进行显著测定,确定出各剂型的增效情况;然后对选出的剂型进行生态和环保特性测定,以便确定新剂型,最后对选定剂型作大区试验来验证田间杀虫药效,最终研制出了4种适合生态农业发展的新型无污染药肥,并对选出的混合剂进行了有效期实验测定。

Methods: Young female mice of Kunming species were randomly divided into the different dosages groups, including control groups, and detecting estrogenic activity by increasing uterus weight; Young female rabbits of New Zealand were randomly divided into the different dosages groups, including control groups, detecting progestational activity by proliferation of rabbit endometrium.

昆明种雌性未成年小白鼠100只随机分为空白对照组、阳性对照组及结合雌激素低、中、高剂量组,采用小鼠子宫增重试验检测各组结合雌激素的活性;新西兰雌性未成年白兔40只随机分为空白对照组、阳性对照组及醋酸甲羟孕酮低、中、高剂量组,采用兔子宫内膜转化试验检测各组孕激素的活性。

The concents of testosterone and NO of the mouses gavaged with high dosages of Chinese chive extractiong were not significantly more than that of giving middle dosages.This indicated that Chinese chives might be more safe than traditional chinese herbals of sexual improvement function.2、The screening of sexual improvement function chemical substances of Chinese chivesThe crude extract was leached to four phases by petroleum ether, ethyl acetate,n-butanol and water.By doing animal tests to detect the contents of testosterone and NO in serum of mices,the result was showed that the extracts of petroleum ether and n-butanol have sexual improvement function,especial the n-butanol phase.

从小鼠灌喂不同剂量的韭菜提取液试验结果来(来源:ABCa539a5论文网www.abclunwen.com)看,灌胃高剂量的小鼠的睾酮含量和NO含量相对于中剂量来说并不上升,而是保持稳定,因为睾酮含量和NO含量过度上升可能会带来付作用,所以由此可以说明其食用安全性高,副作用小。2、韭菜改善性功能物质的筛选将韭菜粗提物依次通过不同溶剂萃取,分成石油醚、乙酸乙酯、正丁醇和水四个萃取相,通过小鼠灌胃的动物试验,以小鼠血液NO含量和睾酮含量为指标,发现正丁醇和石油醚萃取相中的物质有改善性功能的效果,尤其是正丁醇相效果非常显著。

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