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The result was showed that the optimal process conditions were presented as follows: molar ratio of methyl glucose amine to oleic acid 2.5, reaction time 8h, reaction temperature 90℃, and the catalyst dosage 1.5% to the oleic acid reaction.

结果表明，最佳工艺条件为：甲基葡萄糖酰胺和油酸的摩尔比为2.5，反应时间为8 h，反应温度为90℃，催化剂用量占油酸用量的摩尔分数为1.5%。

Certain solid-state properties of the drug substance (e.g., polymorphic form or amorphism, solvation or hydration, various types of inclusion complexes, and particle size or surface area) may profoundly affect dissolution and bioavailability from solid dosage forms or suspension drug products.

一些原料药的固态特性（如：多晶型物或无晶型物，溶剂化作用或水合作用，各种包含物复合体，颗粒尺寸或表面面积），可能极大地影响着固态和悬浮态形式的制剂药品的分解的生物药效率。

Certain solid-state properties of the drug substance (e.g., polymorphic form or amorphism, solation or hydration, arious types of inclusion complexes, and particle size or surface area) may profoundly affect dissolution and bioaailability from solid dosage forms or suspension drug products.

一些原料药的固态特性（如：多晶型或无定型，溶剂化作用或水合作用，各种包涵性复合物，粒度或比表面积），可能极大地影响着固态和悬浮态形式的制剂药品的溶出度与生物利用度。

Results The propfol dosage of smoking cigarette group gained obvious ( P＜0.01), and the anaesthetize result was bad than the matched group.

结果 有吸烟习惯的患者术中异丙酚用量明显增加（P＜0.01），且麻醉效果较对照组差。

Methods 2000 women who desired to terminate pregnancy and operate artificial abortions without pain, were selected to anesthetize with propofol and fentanyl or propofol. The effect of analgesia and the extension degree of cervix were observed, and the time of anesthesia, the dosage of propofol, the time of operation, the time of patients to come around and leave hospital were recorded.

选择要求终止妊娠、自愿接受无痛人工流产术的妇女2 000例，应用丙泊酚复合芬太尼或丙泊酚静脉麻醉，观察镇痛效果、宫颈松弛程度，记录术中出血量、麻醉起效时间、丙泊酚总剂量、手术时间、苏醒时间、离院时间和人工流产综合征的发生情况。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

16Development and production of new products and new dosage forms of antibiotic medical, anthelmintic, insecticide, anti-coccidiosis medicines used for animals

兽用抗菌药、驱虫药、杀虫药、抗球虫药新产品及新剂型开发与生产

Arenaceous qualitative loam is better with medical effect, can decrease appropriately with dosage.

砂质壤土用药效果较好，可适当减少用药量。

The experimental result indicates that the composition can not only enhance the analgesic effect of asarum, but also reduce the dosage of it, therefore ,there will be less toxicity.

实验结果说明这种联合用药不仅能够增强细辛的镇痛效果，而且可以减少细辛的用量，从而减少毒性。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。