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The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system, such as neurodegenerative diseases, The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.

本发明的化合物还可用于预防和治疗TRX-介导的疾病，例如自身免疫性、变应性和炎性疾病，并且用于预防和/或治疗中枢神经系统疾病，例如神经变性性疾病。本发明还提供了包含所述异羟肟酸衍生物的药物组合物以及这些药物组合物的易于依从并且在体内产生治疗有效量的所述异羟肟酸衍生物的安全剂量方案。

Results It showed that the serum active enzymatic of 5′-NT in hepatic and gall diseases,osteal diseases levels were increase, especially the more significant increase of the serum active enzymatic of 5′-NT in level appeared in the patients with hepatic and gall diseases,osteal diseases .

目的 检测各型肝胆疾病、骨骼疾病患者血清5′-核苷酸酶(5′-NT)，谷丙转氨酶和γ-谷氨酰转肽酶，碱性磷酸酶酶活性的变化，观察在肝胆疾病和骨骼疾病中的临床意义，同时与正常健康者作对照。

Results It showed that the serum active enzymatic of 5′-NT in hepatic and gall diseases,osteal diseases levels were increase, especially the more significant increase of the serum active enzymatic of 5′-NT in level appeared in the patients with hepatic and gall diseases,osteal diseases .

结果 发现在肝胆疾病和骨骼疾病时，血清5′-NT酶活性升高，尤其是急性黄疸型肝炎、肝癌、胆道疾病患者血清5′-NT酶活性差异有非常显著性（ P ＜0.01）时，随病情好转，血清5′-NT酶活性有所降低。

Results It showed that the serum active enzymatic of 5′-NT in hepatic and gall diseases,osteal diseases levels were increase, especially the more significant increase of the serum active enzymatic of 5′-NT in level appeared in the patients with hepatic and gall diseases,osteal diseases .

作者：李顺君，黄文方，饶绍琴目的检测各型肝胆疾病、骨骼疾病患者血清5′-核苷酸酶(5′-NT)，谷丙转氨酶和γ-谷氨酰转肽酶，碱性磷酸酶酶活性的变化，观察在肝胆疾病和骨骼疾病中的临床意义，同时与正常健康者作对照。

Male chronic disease is related to hyperlipidemia. Aging is related to higher number of related diseases. Those lived alone with divorce status have a higher percentage of unawared hyperlipidemia. BMI value correlates positively with related diseases and number of diseases. Job holders reported less related diseases. Those who report having hyperlipidemia also register a higher percentage of diabetes. Population in Tauyuan, Shinchu, Miali, Taichung, Chunghua and Nantou counties have higher awareness of self-reporting hyperlipidemia, while population in Kaohsiung, Pingtung and Penhu counties have much lower self-awareness. Furthermore, those having self-reporting hyperlipidemia are statistically significant with their conditions in heart-disease, high-blood pressure, diabetes and kidney disease.

而男性慢性病与高血脂罹患率较高；年龄越大，相关疾病罹患率越高且疾病数越多；离婚分居丧偶自述不知道高血脂疾病状况者较多；BMI值与相关疾病及疾病数成正比；有工作者相关疾病较少；自述有高血脂者，其自述有糖尿病比例最高；桃、竹、苗及中、彰、投地区较清楚自身高血脂疾病状况，而高雄、屏东、澎湖为自述不知道有高血脂机率最高地区；另外自述高血脂疾病状况对心脏病、高血压、糖尿病及肾脏病均达统计显著水准。

This paper first reviews definitions of new infectious diseases and the status of emerging and reemerging infectious diseases. Then it describes the worldwide distribution of new infectious diseases. Finally, it presents an analysis of important factors contributing to new infectious diseases including a combination of biological, environmental, ecological, social and economic factors.

本文先讨论「新兴传染病」的定义及新现与再现两类传染病的目前情况；再论述「新兴传染病」的全球分布趋势；最后，分析「新兴传染病」与人类健康相关的研究，初步归纳出：生物、环境、生态、社会及经济等因素与「新兴传染病」崛起的相互关系。

Group C report the incidence of infectious diseases Habitat top three diseases were: other infectious diarrhoeal diseases, hand, foot and mouth disease and mumps, or C incidence of infectious diseases reported a total of 98.5 percent.

丙类传染病报告发病数居前三位的病种为：其它感染性腹泻病、手足口病和流行性腮腺炎，占丙类传染病报告发病总数的98.5%。

Objective:To observe the changing trend of chronic di seases incidence rate in Chengdu and provide scientific data for effective int erven tion of chronic diseases Methods:Used EXCEL/SAS software to an alyze the surveillance data of chronic diseases in recent ten years Result:Three chronic diseases incidence rate was going up,male incidence rate was higher than that of female Malignant Nepolasm incident rate was first o ne, but Carebrovacular diseases increase was the fastest Diebetes Mellitus...

目的 ：了解成都市 1990～ 2 0 0 0年慢性非传染性疾病发病率的变化趋势，为慢性非传染性疾病的有效干预提供科学的数据。方法：采用 EXCEL、 SAS统计分析 1990～ 2 0 0 0年慢性非传染性疾病监测数据。结果：该市 3种慢性非传染性疾病(恶性肿瘤、脑卒中、缺血性心脏病)发病率呈上升趋势，且男性高于女性，其中恶性肿瘤发病率最高，脑卒中增长最快，恶性肿瘤中以肺癌发病率最高。糖尿病发病率女性高于男性。结论：成都市慢性非传染性疾病发病率正呈上升趋势，必须加强预防控制

Nowadays, cardio/cerebrovascular diseases, cancer, diabetes, mental diseases, traumata and the diseases caused by environmental pollution have markedly increased, while the current medicine always has little effect on such diseases.

现在，心、脑血管病、癌症、糖尿病、精神性疾病、意外伤残及污染性的慢性病明显增加，而目前的医学对这些疾病常无良策。

Nowadays, cardio/cerebrovascular diseases, cancer, diabetes, mental diseases, traumata and the diseases caused by environmental pollution have markedly increased, while the current medicine always has little effect on such diseases. Thus, a medicine that makes people protect their health emerged as required and this medicine is the Fourth Medicine.

现在，心脑血管病癌症糖尿病精神性疾病意外伤残及污染性的慢性病明显增加，而目前的医学对这些疾病常无良策在这种情况下，自己设法维护自身健康的医学必然兴起，是任何力量也阻挡不了的必然趋势，自我保健这一兴起的医学第四医学，也就瓜熟蒂落，应运而生了

The basic concept of FOP can be summarized as to further optimize effective prescription according to the standard of curative effects and with the aid of modern science and technology and theories of traditional Chinese medicine.

其基本内涵可概括为：以确有疗效的中药复方为研究对象，以现代科学技术和传统中医药理论为技术支持，以该复方所治病证的药效响应为评价标准，以优化重组疗效更优的新复方为研究目的。

Ever since our world has been a world, native forests have been indiscriminately exploited by man.

自从我们的世界一直是世界原生森林被任意剥削人。