查询词典 dicer

RNA interference represents a common biological phenomenon of double-stranded RNA mediated post-transcriptional gene silencing, which lies in altitude plants and animals. The mechanism of this process is described as that: the dsRNA in cells are cut into double-stranded small interfering RNA. By joining with an effector complex termed RISC (RNA-induced silencing complex), siRNA binds to the cellular RNA with homologous sequences, and contributes to the degradation of the corresponding mRNA, the inhibition of specific gene expression.

RNAi技术是双链RNA(double strand RNA，dsRNA)介导的序列特异性的转录后基因沉默，广泛存在于高等植物和动物中，其机制是细胞内的dsRNA被Dicer剪切成双链的小分子干涉RNA (small interfering RNA，siRNA)与RNA诱导的基因沉默复合物结合，降解与之互补的靶mRNA，特异性抑制靶基因表达。

The amazing Nicer Dicer from Genius will make your life easier, safer and more fun in the kitchen.

这一切都来自奇妙的发明，令人惊叹的多功能切菜器。它将使你的生活变的更加容易，更加安全和更加有趣。

In this review, we discuss the general mechanisms of RNAi and the recent progresses in the study of Dicer protein.

后来的研究表明，RNAi现象存在于几

DGCR8, Dicer and Ago2 are essential factors for miRNA homeostasis.

DGCR8， Dicer 和 Ago2 是维持miRNA稳态的重要因子。

Methods We measured messenger RNA levels of Dicer and Drosha in specimens of invasive epithelial ovarian cancer from 111 patients, using a quantitative reverse-transcriptase–polymerase-chain-reaction assay, and compared the results with clinical outcomes.

我们用定量RT-PCR的方法检测了111例侵袭性上皮卵巢癌标本中Dicer 和Drosha酶的mRNA的水平，并且分析其与临床预后的关系。

Genetic silencing of Dicer and Drosha significantly reduced capillary sprouting of endothelial cells and tube forming actiity.

结果发现，siRNA将Dicer 和 Drosha沉寂后，能显著减少内皮细胞毛细血管出芽形成和门管形成活性。

Cleavage by Dicer creates short double-stranded RNAs that are characterized by two nucleotide long, 3' overhangs.

Dicer切割后会产生一类在3'端有2个核苷酸突出之小段双股RNA，即siRNA，意为「小片段的干扰RNA」。

In vivo, CD11b+-cre/Dicer-null mice had mild osteopetrosis due to decreased osteoclast number and bone resorption.

体内实验发现，由于破骨细胞数目减少以及骨吸收作用降低，CD11b+-cre/Dicer-null小鼠表现出轻微的骨硬化症。

Different from the siRNAs or miRNAs, which are derived from double-stranded or short-hairpin RNA precursors, piRNAs are derived from single-stranded RNA precursors or two non-overlapping and divergently transcribed precursors without the involvement of Dicer endonucleases.

与来自于双链RNA的siRNA和发卡结构miRNA不同之处是piRNA来自长单链RNA前体，或者是两股非重叠的反向转录前体，其生成与Dicer无关。

Although the specific mechanism is poorly understood, it is known that the ribonuclease enzyme Dicer binds to and cleaves short double-stranded RNA molecules to produce double-stranded fragments of 21-23 base pairs with two-base single-stranded overhangs on each end.

虽然具体机制很难懂，它知道，核醣核酸酵素Dicer 束缚对和劈开短的double-stranded 核糖核酸分子导致21-23 基本的对的double-stranded 片段以二基地唯一搁浅的突出物在各个末端。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。