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Despite current therapies for multiple myeloma, clinical outcome is often poor, variable, and unpredictable, writes editorialist Thomas Gilmore, PhD, from Boston University, in Massachusetts. Hence, much effort has been devoted recently to using genetic approaches to define MM molecular subtypes and how these may be used to direct and predict susceptibility to various treatment regimens, he adds.

"虽然目前骨髓瘤的临床治疗成果常常是贫乏、多变且不可预计，"来自马萨诸塞州波士顿大学的哲学博士编辑Thomas Gilmore写道，然而，最近许多研究利用基因技术的新突破来确定骨髓瘤的分子亚型以及这些可能在指导和预示对于众多治疗方案敏感性的方面的得到应用。

In the hands of Watt, the instrument maker, who devoted almost a life to the subject, the condensing engine acquired gigantic strength; and George Stephenson, the colliery engineman, was certainly not the least of those who have assisted to bring the high- pressure engine to its present power.

煤矿机械师乔治·斯蒂芬森当然也只是那些曾经努力使高压力发动机获得目前的力量的人员之一。海纳百川，有容乃大；壁立千仞，无欲则刚！

I, who have made literature my profession, and devoted my life to it, and have never for a moment repented of the deliberate choice, think myself nevertheless bound in duty to caution every young man who applies as an aspirant to me for encouragement and advice against taking so perilous a course.

虽然我已把文学作为自己的事业，而且将为此献出我毕生的精力，绝不会对自己深思熟虑后的选择后悔片刻，然而，我还是感到自己有责任向每一位有抱负的青年求助者和讨教者提出忠告：不要走这条危险的道路。

As a result of the deficit of in successive years, at present capital is not worth badly, difficulty of have enough to meet need, add the effect of the macroclimate before be duped, effective supply of goods is insufficient, customer money volume drops somewhat, carriage income is serious coast, transform in what want devoted carriage hardware already, again many is in circuit disease to want a variety of circumstances such as punish to fall, the situation is very grim.

由于连年的亏损，目前资金严重不足，周转困难，加上当前大气候的影响，有效货源不足，客货运量有所下降，运输收入严重滑坡，在既要投入运输硬件的改造，又有多处线路病害要整治等多种情况下，形势十分严重。

Mr Singh has devoted plenty of effort during his prime ministership to trying to improve relations with Pakistan, and to moving the endless argument between the two countries over the disputed state of Kashmir forward a little.

在其总理任期内，辛格先生为了改善同巴基斯坦的关系，推动双方有关克什米尔这个有争议地区的无休止的争论向前稍有发展，做出了许多努力。

The second chapter describes Tess as a pure woman, arguing that it is Tess"s sense of duty to her family on the decline that leads her to become Alec"s sexual object and later it is her devoted love to Angel that makes her the murderess of Alec.

第二章论述苔丝的纯洁形象，认为是苔丝对其贫困家庭的高度责任感和牺牲精神导致她的沉沦，是她对丈夫忠诚的爱导致她最后杀死了亚力克。

Joseph of St. Mary (Nicholas Rider, 1600-82), after many years of fruitful activity, devoted his old age to the training of aspirants to the order; these were sent abroad for their novitiate and studies and on their return were appointed to one or other of the missionary stations belonging to the order.

约瑟夫的圣玛丽（尼古拉莱德， 1600年至1682年），经过多年的富有成效的活动，致力于自己的晚年生活，以培养有志成为该命令；这些被送往国外，为他们novitiate和研究，他们在回港后获委任进入一个或其他的传教站属于该命令。

"Sire," said Villefort, the suddenness of this event must prove to your majesty that the issue is in the hands of Providence; what your majesty is pleased to attribute to me as profound perspicacity is simply owing to chance, and I have profited by that chance, like a good and devoted servant--that's all.

"陛下，"维尔福说，事态变化之迅速足以向陛下证明：只有上帝掀起一阵风暴才能把它止祝陛下誉臣有先见之明，实际上我纯粹是出于偶然，我只不过象一个忠心的臣仆那样抓住了这个偶然的机会而已。

PHYSIOGRAPHIC BASIS OF THE PLACE NAME COVER To place name cover in relation to the earth's surface itself less attention has been devoted by American students than to its histonrcal and social aspects.

地名覆盖的地文学基础对于地名覆盖与地球表面本身的关系，美国学生一直不像对历史和社会方面那么给予那么大的注意。

Powder Mill is a high-pressure resistant equipment company technical experts in the many years of research based on the industrial mills, drawing on the fineness of Germany and Japan advanced classification technology, according to fluid mechanics, devoted themselves to developing out with Jet Mill powder mill efficiency comparable to solve the domestic use of the high cost of jet mill problem, solve the ultrafine classification difficulties.

商品简介：高压微粉磨粉机是我公司耐磨设备技术专家在多年的研究工业磨粉机的基础上，吸取了德日先进的细度分级技术，根据流体力学原理，潜心研制出的可与气流磨相媲美的高效微粉磨机，从而解决了国内采用气流磨成本高的难题，解决了超细粉分级难关。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。