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Beta-thalassemia major is a serious hereditary hemolytic anemia which does great harm to human being.It is a monogenic disease characterised by a reduced synthesis of beta-globin chains,which dues to the Doint mutation or deletion of beta-globin gene and its control region.It not only decreases the hemoglobin level,but breaks the balance of alpha/beta synthesis ratio.The major cellular pathogenetic mechanisms in beta thalassemia are based primarily on the deleterious effects produced by the accumulation of the excess alpha globin chain.These excess alpha-globin chains cannot form stable tetrameric structure and deposit in erythroid cells.They cause large ineffective erythropoiesis on their own,accelerate red cells destruction,and lead to hemolysis.

地中海贫血是一种对人类健康危害严重的遗传性溶血性贫血病，是因β-珠蛋白基因及其调控序列的点突变或缺失致使β-珠蛋白肽链合成减少或完全停止，这不仅使患者血红蛋白水平降低，而且使原来在数量上与之持平的α-珠蛋白肽链相对过剩，这些相对过剩的游离α-珠蛋白肽链并不能形成稳定的四聚体，它们沉积在红细胞中导致了大量无效红细胞生成和红细胞寿命缩短，引起了严重的溶血性贫血。

He sings in a Taipei pub these days and is burdened with amounting debts and unsurmountable alcohol he consumed over the years are now having deleterious effect on his life.

十年了，他长期在台北城市的一间Pub里驻唱娱乐观众，而满身的债务和酒精捆绑著他，让他失去了快乐的权利。

Endothelin-1 (ET-1) is a potent vasoconstrictive peptide that was isolated initially from the conditioned medium of cultured endothelial cells. It is a pathogenic mediator with a number of deleterious effects, including vasoconstriction, fibrosis, vascular hypertrophy,and inflammation.Atrial natriuretic peptide, angiotensin II and nitric oxide also takes an important role in cardiovascular system.

内皮素-1(endothelia-1，ET-1)是一种由内皮细胞合成和分泌的、具有强烈收缩血管作用和促进细胞增生的血管活性多肽，心钠素(atrialnatriuretic peptide，ANP)、血管紧张素Ⅱ(angiotensin Ⅱ，AⅡ)、NO等在心血管系统功能的调节中也起着重要作用。

The anion has as follows 8 big benefit: Sterilize surpass the oxygen negative ion free radical but kill various pneogaster infectious disease bacterium; Dust removal makes air middle dust heavy getting together, suspension pellet the brute force is collected; Deodorization dislodges various the peculiar smell living , bad smell , improves a bag; Eliminate cigarette smoke fog , dust in wiping out air rapidly , completely eradicate the second-hand cigarette; The various deleterious chemistry volatilizes a gas , wipes out "the invisible killer " in getting rid of poison dislodging air; Work efficiency, removes health care rise becoming fagged , improve the heart-lung function, strengthen the human body immunocompetence; Improve the looks making an epithelium bring negative charge along , make germs lose the go at ability to the cell , keep skin glossy; Except that static electricity is positive static electricity in general in life, will be physically and mentally healthy to the human body bringing about hidden trouble, the anion has an effect to neutralize this static electricity.

负离子有如下8大好处：杀菌——超氧阴离子自由基可杀灭各种呼吸道传染病菌；除尘——使空气中尘埃聚沉，强力收集悬浮颗粒；除臭——去除各种生活异味、臭味，改善生活环境；消烟——快速消灭空气中的烟雾、尘埃，杜绝二手烟；去毒——去除空气中各种有毒化学挥发气体，消灭&隐形杀手&；保健——提高工效、消除疲劳，改善心肺功能，增强肌体免疫能力；美容——使上皮细胞带负电荷，使病菌失去对细胞的攻击能力，保持皮肤光滑；除静电——生活中一般为正的静电，会对人体身心健康带来隐患，负离子有效中和这种静电。

We have proven that the accumulation of superoxide will be dangerous by disproportioning to other deleterious ROS such as H〓O〓 and ·OH, although superoxide is less harmful than singlet oxygen because of the capability of artificial quinone to partially prevent PS Ⅱ reaction center complexes from photodamage.

发现受到光抑制破坏的PS Ⅱ仍能生成O〓，尽管重组醌对PS Ⅱ反应中心复合物的保护作用表明O〓对PS Ⅱ的破坏性可能不如单线态氧强，但它可以通过诱发生成的其它活性氧物种，如H〓O〓和·OH等，导致对PS Ⅱ造成显著的破坏，因而过多的O〓生成对高等植物是有害的。

What is "significant" about these developments, but in a way potentially deleterious for scholarship, is that they conspire to create availability cascades that result in inferior work getting the most scholarly attention and, in the process, lowering the general quality of scholarly discourse.

对这些动向而言，&重要的&是它们可能会导致叠加效应，即可能对学术又潜在的危害，其结果是劣质的作品吸引了最多的学术注意力，并在这个过程中降低学术交流的整体质量，。

PN carries the considerable risk of overfeeding which can be as deleterious as underfeeding.

PN可能导致营养过度，营养过度与营养不足同样有害。

This would lead to a selective pressure on men to take the task of propositioning very seriously indeed. Making a bad mistake would be almost as deleterious to the potential for reproduction, as forgetting to bring a dagger to a knife fight.

这就导致选择性的压力，当一个男人必须相当严肃的对待他试图接近的异性时，一个的错误都可能导致这个男人传宗接代的可能性成为泡影，而这无异于自杀，就像拼刺刀时不带刺刀一般。

Normally the lysosomes may be protecting the cell from the deleterious effects of such ions, by sequestering them.

在正常情况下，容酶体将这些金属离子隔离，保护细胞免受其有害的作用。

Normally the lysosomes may be protecting the cell from the deleterious effects of such metal ions, by sequestering them

在正常情况下，溶酶体将这些金属离子隔离，保护细胞免受其有害的作用。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。