查询词典 daphnetin

Objective To investigate the therapeutic effect of a combination of artemether and daphnetin against Plasmodium berghei ANKA strain in mice. Methods Groups of P.

目的 研究蒿甲醚与瑞香素伍用对感染伯氏疟原虫ANKA株小鼠的疗效及其联合作用方式。

Results In vitro ,daphnetin exhibited potent schizontocidal activity comparable to chloroquine at the dose range of 1～10 μmol/L. In vivo ,50 or 100 mg/kg.d -1 ×4 d daphnetin i.g. and 10,50 or 100 mg/kg.d -1 ×4 d dephnetin i.p. showed antimalarial efficacy comparable to CQ 10 mg/kg.d -1 ×4 d i.g. in mice infected with P. berghei ANKA, evaluated by both the reduction rate of parasitemia on D 4 and the average surviving days in 30 days.

结果 体外试验中瑞香素在 1～ 10 μmol L剂量范围内有明显杀灭裂殖体作用，而体内试验中按D4减虫率与感染鼠在 30d内的平均生存天数评价，5 0或 10 0mg kg 。d- 1 × 4d瑞香素灌胃以及 10 ，5 0或 10 0mg kg.d- 1 × 4d瑞香素腹腔注射给药在伯氏鼠疟原虫ANKA株感染鼠中的抗疟作用与 10mg kg 。d- 1 × 4d氯喹灌胃的疗效相似。

The inhibition level by daphnetin for 1, 2, 3 and 4 h were 7%, 51%, 69% and 75% respectively, while the values treated by daphnetin-Fe complex were 8%, 6%, 11% and 9% respectively. The inhibition level by daphnetin at different concentrations （0.1, 1, 100 and 1 mmol/L） for 6 h was 3%, 31%, 58% and 93% respectively and while the values treated by daphnetin-Fe complex were 8%, 6%, 11% and 9%.

经瑞香素（100 μmol/L）作用1、2、3和4 h后RNR活性分别被抑制7%、51%、69%和75%；在瑞香素浓度为0.1、1、100和1 000 μmol/L，作用6 h后，RNR活性分别被抑制3%、31%、58%和93%；而瑞香素-Fe复合物作用6 h后RNR活性分别被抑制8%、6%、11%和9%。

Result The parasites synchronized with sorbitol in vitro was treated by daphnetin and daphnetin-Fe complex.

经瑞香素（100μmol／L）作用1、2、3和4h后RNR活性分别被抑制7％、51％、69％和75％；在瑞香素浓度为0.1、1、100和1000μmol／L，作用6h后，RNR活性分别被抑制3％、31％、58％和93％；而瑞香素-Fe复合物作用6h后RNR活性分别被抑制8％、6％、11％和9％。

Methods:The Caco-2 cell monolayer model was used to study the bi-directional transport of daphnetin and the effects of time,temperature,pH,drug concentration and P-gp inhibitor on the daphnetin absorption.Drug concentration was measured by HPLC and the apparent permeability coefficients were calculated.

采用Caco-2细胞单层模型研究祖师麻甲素的摄取和跨膜转运，采用HPLC法检测药物浓度，计算其表观渗透系数，考察时间、温度、pH值、药物浓度以及P-gp抑制剂对祖师麻甲素吸收的影响。

The inhibition level of the COX activity by daphnetin after being treated for 2, 4, 8 and 12 h were 0.6%, 73% and 80% respectively and the inhibition level by daphnetin at different concentrations （0.1, 1, 100 and lmmol/L） for 6h was 3%, 31%, 53% and 84%, respectively.

在体外瑞香素可显著降低恶性疟原虫的细胞色素C氧化酶及核糖核酸还原酶活性。

Methods The effect of daphnetin, daphnetin-Fe complex and desferrioxamine B on SOD activity of P. falciparum FOCI in vitro was determined with a SOD test-kit.

方法在恶性疟原虫FCC1株体外培养体系中，以SOD试剂盒检测瑞香素、瑞香素铁盐及去铁胺对疟原虫SOD活性的影响。

The effect of daphnetin and daphnetin-Fe complex on COX and RNR activity of P.falciparum was tested by ultraviolet spectrophotometer and electron spin resonance respectively.

结果 体外同步培养的恶性疟原虫经瑞香素（100μmol／L）作用2、4、8和12h后，COX活性分别被抑制了0、6％、73％和80％；在瑞香素浓度为0.1、1、100和1000μmol／L，作用6h后，COX活性分别被抑制3％、31％、53％和84％；而瑞香素-Fe复合物对COX的影响几乎消失。

The passive diffusion is the major transport of daphnetin uptake and absorption by Caco-2 monolayer.P-gp has no efflux effects on the uptake and transepithelial transport of daphnetin.

祖师麻甲素是以被动扩散为主要方式被小肠上皮细胞摄取和转运，此过程不受P-gp的外排作用。

The formation and characters of the vesicles were demonstrated by negative-staining TEM and dynamic light scattering. Using the vesicles as the delivery of daphnetin, we carried out the research on the effect of formation and temperature upon entrapment efficiency. Research had also been carried out upon the release circumstance of daphnetin contained in the vesicles in simulated gastric and intestinal fluid.

选择生理上能接受的2种表面活性剂，即仿生磷酯阳离子表面活性剂PTA与阴离子表面活性剂SDS，按一定比例复配能自发形成稳定性囊泡，用负染色透射电镜和动态光散射对其进行表征，并以其作为药物瑞香素的载体开展其组成、温度对包封率的影响，以及在模拟胃液及模拟肠液中的释放情况的研究。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

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