查询词典 cultures

For most viruses,there is aneed for antimicrobials that target unique viral molecular properties.Acycloviris one such drug.It is activated into ahuman herpesvirusDNA polymerase inhibitor exclusively by HHV kinases and,thus,does not suppress other viruses.Here,we show that ACV suppresses HIV-1in HHV-coinfected human tissues,but not in HHV-free tissue or cell cultures.However,addition of HHV-6-infected cells renders these cultures sensitive to anti-HIV ACV activity.We hypothesized that such HIV suppression requires ACV phosphorylation by HHV kinases.Indeed,an ACV monophosphorylated prodrug bypasses the HHV requirement for HIV suppression.Furthermore,phosphorylated ACV directly inhibits HIV-1reverse transcriptase,terminating DNA chain elongation,and can trap RT at the termination site.These data suggest that ACV anti-HIV-1activity may contribute to the response of HIV/HHV-coinfected patients to ACV treatment and could guide strategies for the development of new HIV-1RT inhibitors.

对大多数病毒而言，都需要有针对其分子特性的靶向杀毒剂阿昔洛韦就是这样一种靶向药物在人疱疹病毒酶的特定作用下，阿昔洛韦被激活成为人疱疹病毒DNA聚合酶抑制剂，因此不能再抑制其它的病毒我们的研究发现阿昔洛韦在共感染人疱疹病毒的组织中可以抑制HIV-1，但在无人疱疹病毒感染的组织或细胞中无此作用然而，加入人疱疹病毒-6感染的细胞却使得其对抗HIV的阿昔洛韦变得敏感我们推测这种抑制作用依赖于人疱疹病毒酶导致的阿昔洛韦磷酸化实际上，单磷酸化的阿昔洛韦前体药物无需人疱疹病毒的参与即可抑制HIV此外，磷酸化的阿昔洛韦能直接抑制HIV-1逆转录酶，将其阻止在终止位点，从而终止DNA链的延长这些结果提示阿昔洛韦的抗HIV-1活性决定了艾滋病病毒/人疱疹病毒共感染的患者对阿昔洛韦的治疗反应，也有助于开发新的HIV-1逆转录酶抑制剂

Khevsureti - one of the most beautiful mountainous region of east Georgia. It was there over a period of centuries that the unique cultures Khevsurs, Pshavs, Tush's were created. One of basic elements of these original cultures was a systematized military infrastructure.

克黑苏拉提为格鲁吉亚东部风景极为优美的山区，在数个世纪的漫长岁月中，这里形成了独特的克黑苏、普夏夫和塔什文化，严密军事体系为这些山地文明的重要组成部分。

In some cultures graphic depictions of sexual behaviors are uncontroversial and helpful, but in other cultures they may be counterproductive.

在一些文化中，性行为的图表公布的统计数据是无可争辩的和有用的，但是在其他的文化中，性行为的统计数据可能恰好相反，这让许多人反感不已。

There are more and more researches on such basketball cultures as nba, cba and cuba, especially on professional basketball cultures, but most of the researches are theoretical researches, there is a lack of empirical study, and the research methods and means are undiversified.

摘 要：篮球运动的文化属性已被学界认可，但是篮球文化的公认定义并没有形成，对篮球文化的概念及结构的研究还存在分歧。nba、cba、cuba等篮球文化的研究越来越多，特别是职业篮球文化的研究，但多数研究是理论研究，缺乏实证研究，方法和手段较为单一。

His diasporic identity, on the one hand, makes him always have the feeling of vagabondism and guest, but on the other hand, enables him to stand on the margin of the two different cultures and offers him the priority to observe and retrospect the two cultures.

他的流散身份一方面带给他身在异乡为异客的感觉，同时又使得他站在两种文化的边缘，对其加以观察和反思。

"We cannot absolutize or dehumanize the protection of ethnic minority cultures and must take into account the evolution and development of these cultures," he told reporters, adding that preservation does not mean isolation.

&我们不能绝对化或非人性化少数民族文化的保护，我们必须考虑到这些文化得发展和进步&，他对记者说。他还加了一句，保护并不意味着孤立。

To identify whether our previous founding were exist in the series of our newly established cell cultures with the same genetic background and different metastatic potentials, and to make clear what are congenerous and various traits in the chromosomal or DMA sequence levels between these cells, in this study, a combination of conventional G-banding, comparative genomic hybridization, multiplex fluorescence in situ hybridization and arm or locus-specific fluorescence in situ hybridization were used to comprehensively characterize molecular cytogenetics aberrations of the above cell cultures.

为查明我所新建立的这些具有同一遗传背景而又在肝癌的转移潜能上存在明显差异的细胞是否也具有8p的缺失，并弄清它们在其它染色体及其区段的DNA水平上有着怎样的相似和不同，这些相似与不同又有着怎样的意义，本课题联合应用G显带技术、比较基因组杂交技术、多重荧光原位杂交技术和位点或臂特异荧光原位杂交技术，对上述细胞进行细胞及分子遗传学研究，以期了解其分子细胞遗传学异常的特征、找出转移相关的遗传学标记，为探讨肝癌转移机制提供材料。

The concept of creolization has been refined by examining the ways in which "dominant" cultures are influenced by "minority" cultures e.g.

正是在这个意义上，赫尔曼·古特曼把&克里奥耳化&定义为&从非洲的到非裔美国的变形&。

Genital tract HIV-1 shedding, defined as HIV-1 RNA or culturable virus in genital secretions, was found in 80% of women with detectable plasma RNA and in 78% of women with positive peripheral blood mononuclear cell cultures. One-third of women with low or undetectable plasma RNA and 39% of those with negative PBMC cultures also had genital tract shedding.

应用细胞质内核醣核酸检测技术，80%的妇女被检测到HIV-1阳性的生殖道分泌物，检测物件可以是HIV-1的核醣核酸，也可以是从生殖道分泌物中培养出来的HIV-1病毒。78%的妇女的周边血液单核细胞培养结果呈现阳性。

However, the 3 groups from medium A exhibited the highest microbial diversity and best decolorization results with 99.53% and 97.42% color removal rate of Reactive Red M-3BE and Acid Red. From them, 16 strains of fungi were isolated and primarily identified as Saprolegniaceae, Eurotiaceae, Erysiphaceae and Physodermataceae . Fungi groups from medium B and D exhibited a bit lower color removal rate of various dyes and only 3 and 2 isolates primarily classified as Saccharomycetaceae and Eurotiaceae were obtained from them. Fungi cultures in medium A and B could produce lignin peroxidase, and those in medium D could be detected higher activity of laccase. All the fungal cultures exhibited very weak activity of manganese dependant peroxidase.

来自A培养基的3组菌群显示出最好的脱色效果和最大的菌群丰富度，对50mg/L的活性红M-3BE和酸性红A溶液的脱色率最高达到99.53%和97.42%，从中分离到了16株真菌，初步鉴定分属于水霉科、曲霉科、节壶菌科和白粉菌科；而B和D培养基中所获得的菌群脱色效果稍差，从中仅得到3株和2株真菌，初步鉴定属于酵母和青霉。A、B两种培养基在各种染料存在下更易产生木质素过氧化物酶，产漆酶能力较弱，而D培养基产漆酶活性较高。

But this is impossible, as long as it is engaging in a market economy, there are risks in any operation.

但是，这是不可能的，只要是搞市场经济，是有风险的任何行动。

We're on the same wavelength.

我们是同道中人。