查询词典 crocin

Objective: To investigate the changes of gene expression profile in transitional cell carcinoma of bladder T24 cell after crocin treatment, in order to find the possible crocin targets.

中文摘要：目的：应用基因表达谱芯片研究藏花素对膀胱移行细胞癌T24细胞基因表达谱的影响。

Objective: To study the effect of Crocin on the expression of VEGF-C in transitional cell carcinoma of bladder T24 cell. Methods: 24 cells were treated with Crocin.

目的：研究藏花素对膀胱移行细胞癌T24细胞血管内皮生长因子C(Vascular endothelial growth factor， VEGF-C)表达水平的影响。

The crocin synthesis mechanism was investigated at the molecular level by studying the genes related to crocin syntheses.

对藏红花苷合成的相关基因进行了初步分离与克隆实验研究，旨在分离与藏红花苷合成相关的特异性表达的cDNA克隆，为进一步从分子水平上研究藏红花素的合成机理奠定基础。

Result: The growth of T24 cells was remarkably inhibited after treatment of crocin. Flow cytometric profiles revealed that crocin led to the increase of the cells in G0/G1 phase, the percentage of cell apoptosis was also increased.

结果：Crocin能明显抑制人膀胱癌T24细胞的生长，并使T24细胞呈明显的G0/G1 期阻滞现象；T24细胞早期凋亡率随crocin作用时间的延长而逐渐增加。

Crocin can induce the significant alteration of gene expression profile of T24 cell. It is suggested that the widly konwn anti-tumor effects of crocin are medicated at least in part by regulating the cell cycle controlling gene expression.

藏花素可以诱导T24细胞基因表达谱广泛的改变，并可能通过调控细胞周期相关基因的表达来抑制T24细胞的增殖。

When 3 mmol·L-1 crocin treated T24 cells for 48h, the difference was significant compared with the control group ( P .05). Crocin induced wide changes of the gene expression profile of T24 cells. A total of 836 genes were up-regulated or down-regulated by more than 2 times, which were involved cell cycle controlling, DNA cell apoptosis, replication factor, and so on.

基因芯片检测发现3 mmol·L-1藏花素作用T24细胞48 h引起该细胞系基因表达谱广泛地改变，其中表达差异2倍以上的基因共836个，这些差异表达基因的功能涉及多个方面，最为明显的是与细胞生长调节相关的细胞周期调节基因、细胞凋亡调控基因、DNA复制相关基因等类型。

After treatment with 50 mmol·L-1 crocin, the inhibited growth of tumor was observed. Electronic microscope was used to observe the morphological changes. The expressions of Bcl-2, Bax, Survivin and Cyclin D1 were detected by immunohistochemistry.

随机分为对照组和处理组。50 mmol·L-1 crocin处理后，观察其对肿瘤的抑制作用；电镜观察肿瘤组织形态改变；SP-免疫组织化学法分析Bcl-2，Bax，survivin，Cyclin D1蛋白表达。

Crocin exerts both in vitro and in vivo anti-cancer effect on TCCB T24 cell line. The mechanisms may change tumour cell cycle and induce tumour cell apoptosis by down-regulating the expression of Bcl-2, Survivin, Cyclin D1 and up-regulating the expression of Bax.

Crocin对人膀胱癌T24细胞株的体内外增殖均具有良好的抑制作用，其机制可能是改变细胞周期分布和诱导细胞凋亡，作用机制与下调Bcl-2， survivin，Cyclin D1基因表达和上调Bax的基因表达有关。

Results: The growth of T24 cells was inhibited significantly P.05 at 3mmol/L Crocin when treated for 48h. And there was a marked positive correlation between Crocin concentration, time and inhibition rate.

结果：MTT显示藏花素抑制T24细胞生长具有时间和剂量依从性，3mmol/L藏花素作用48h对T24细胞的抑制率最高。

Crocin could inhibit the growth of BALB/c xenograft tumor. The morphology changes of cell apoptosis were observed. Bcl-2, Cyclin D1 and survivin expressions determined by immunohistochemical staining were down-regulated after treatment with Bax expression up-regulated.

Crocin对人膀胱癌裸鼠移植瘤的生长具有抑制作用，电镜观察可见细胞凋亡的形态学改变，免疫组化结果显示，经Crocin处理后Bcl-2， survivin，Cyclin D1的表达下调，而Bax的表达上调。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。