查询词典 cox

The development, molecular base, Structure-activity relationship and classification of the COX-2 inhibitor as well as pharmic character , development status and trend of Lumiracoxib were reviewed in this paper.

本论文综述了COX-2抑制剂的发展、分子基础、构效关系、分类以及氯美昔布的药学特性和发展现状及趋势。

Objective To investigate the expression pattern of COX-2 in adult rat pilosebaceous unit.

目的研究环氧合酶-2（cyclooxygenase-2， COX-2）在成年大鼠毛囊皮脂腺单位中的表达模式。

In our stydy, we explored the expression pattern of COX-2 in normal rat Pilosebaceous Unit and hair follicle cycle adopting immunochemistry and RT-PCR methods.

毛囊皮脂腺单位中COX-2仅在表皮基底上层细胞和皮脂腺中，而在毛囊各层细胞中基本未见表达(仅在特化的触须毛囊外根鞘有轻微表达)。

Results COX-2 expression in pilosebaceous unit of adult rat showed strongly positive at sebaceous gland, positive in bulge region and negative in hair matrix.

而COX-2在正常毛囊皮脂腺单位(pilosebaceous unit，PSU)中是否具有作用尚少见研究报道。

Objective To investigate the expression and the significance of cyclooxygenase-2 (COX-2)and survivin in the benign and malignant pleomorphic adenoma of saliva ry gland.

目的 探讨环氧合酶- 2 (COX- 2 )及生存素在良、恶性涎腺多形性腺瘤中的表达及其与肿瘤发生发展的关系。

GLM specific models: Binomial regression, polytomous regression, Cox proportional hazard, log linear.

GLM。特殊模型：二项回归，多项回归， Cox 比例风险，对数线性模型。

Objective The purpose of present study was to evaluate the relative contributions of prostacyclin (PGI2) and the expression of COX mRNA in the hyperdynamic circulatory state of chronic portal hypertensive rats. Methods Twenty male Sprague-Dawley rats were divided into three groups: intrahepatic portal hypertension by injection of CC14, prehepatic portal hypertension by partial stenosis of the portal vein and sham-operated controls.

目的 研究门静脉高压症鼠血浆前列环素(PGI2)水平、血管和小肠中环加氧酶基因表达以及内脏血流动力学的变化，探讨PGI2、COX mRNA表达与门静脉高压症高血流动力学之间的关系。

In the tumor model of pyretic syndrome, contents of PGE2、IL-8、TNF-α、and COX-2 proteinum high and contents of ICAM-1 and VEGF proteinum was low. There are the inhibited action on tumor in the group of Xiaotansanjie、Qingrexiaotan and chemotherapy. Results The the tumor model of pyretic syndrome was successful to be established.

结果成功建立热邪干预下S180肉瘤模型，并且此模型动物PGE2水平升高，符合热邪本质；在热邪干预下S180肉瘤模型中炎性因子PGE2、IL-8、VEGF以及COX-2表达明显增强，而TNF-α、ICAM-1表达增强不明显。

Cells were immediately fixed and processed for immuno?uorescence and tested for translocation ofβ-catenin.β-catenin and target genes of Wnt/β-catenin signaling COX-2, cyclinD1, c-fos, c-Jun mRNA expression were examined by RT-PCR. Saos-2 osteoblastic cells were co-transfected with a wild type or mutant Tcf luciferase reporter gene and Renilla luciferase plasmid. Posttransfection cells were subjected to 1 hour of 12% elongation.

作用1h、2h和4h后，用免疫荧光的方法检测β-catenin的表达和在细胞上定位的变化；用半定量RT-PCR检测β-catenin mRNA表达的变化；用质粒转染的方法检测荧光素酶报告基因Tcf转录的情况；用半定量RT-PCR检测Wnt/β-catenin通路下游基因COX-2，cyclinD1， c-fos， c-Jun mRNA表达的情况；用免疫共沉淀的方法检测β-catenin和E-Cadherin的结合情况。

Results(1) Group of electroacupuncture in Shu and dense wave can significantlyreduce the degree of ankle swelling(P＜0.05, P＜0.01), which shows thatelectroacupuncture has obvious anti-inflammatory and repercussive roles;(2) Theresults of HE staining showed that group of electroacupuncture in Shuand dense wave can significantly reduce inflammatory cell infiltration,inhibit synovial cell proliferation, and decrease proliferation of granulationtissue in rats joints;(3) group of electroacupuncture in dense-wave can increase the pain thresholdof experimental rats (P＜0.05, P＜0.01), reduce the content of peripheral painmediums, such as K~+, DA and 5-HT(P＜0.05, P＜0.01), which shows thatelectroacupuncture has significant analgesic effect;(4) In the local lesion of joints, electroacupuncture can significantly reducethe content of IL-1β, IL-8, TNF-a, increase IL-4 content, decrease theexpression of COX-2mRNA, and significantly promote the expression ofHSP-70 protein in synovial tissues of acute gouty arthritis rats (P＜0.05,P＜0.01),thus restrain the occurrence of synovial tissue inflammation.

结果：(1)电针疏密波组能显著减轻踝关节肿胀度(P＜0.05，P＜0.01)，表明电针有明显的抗炎消肿作用；(2)HE染色显示：电针疏密波组可使大鼠关节炎症细胞浸润明显减轻，滑膜细胞增生明显被抑制，肉芽组织增生明显减少；(3)电针密波组能提高实验性大鼠痛阈(P＜0.05，P＜0.01)，降低外周疼痛介质K~+、DA、5-HT的含量(P＜0.05，P＜0.01)，表明电针有明显的镇痛作用；(4)在病变关节局部，电针能显著降低急性痛风性关节炎大鼠滑膜组织IL-1β、IL-8、TNF-α含量(P＜0.05，P＜0.01)，升高IL-4的含量(P＜0.05，P＜0.01)，并降低关节滑膜内COX-2mRNA的表达(P＜0.05，P＜0.01)，可促使急性痛风性关节炎大鼠滑膜内HSP-70蛋白表达显著增加(P＜0.05，P＜0.01)，从而抑止滑膜组织炎症发生。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。