查询词典 cox

To investigate the expression of cyclooxygenase-2(COX-2) in carcinogenesis lesions of oral submucous fibrosis, and the effects of arecoline on the expression of COX-2 in cultured human oral keratinocytes.

目的 探讨环氧合酶－2(COX-2)在口腔黏膜下纤维性变癌变组织中的表达，观察槟榔碱对人口腔角质形成细胞COX-2表达的影响。

First, the individuals who would be most likely to benefit need to be identified, writes editorialist Sanford Markowitz, MD, PhD, from Case Western Reserve University, in Cleveland, Ohio. Then, it needs to be shown that certain persons reproducibly demonstrate high COX-2 expression in independent adenomas or cancers, because of genetic predisposition or environmental exposures. And third, the work of Dr. Chan and colleagues needs to be extended by demonstrating that prevention of colon adenomas by aspirin or COX-2 inhibitors also involves blocking the development of the highest COX-2–expressing lesions, he says.

俄亥俄州克里夫兰Case Western Reserve大学的Case Western Reserve医师表示，首先，必须要拿找出最能受益的一群病患；接著，必须要能证实部分病患的独立腺瘤或癌症，因为基因及环境的影响，会一再地是高度表现COX-2的；第三，Chan医师与其同事的研究，需要透过aspirin或是COX-2抑制剂可以预防大肠腺瘤的作用，也牵涉到阻断COX-2表现病灶的生成。

In previous studies, Cyclooxygenase-2(COX-2) is believed to be linked with inflammations and tumors. But in recent reports, COX-2 is found to play important roles in osteoblastic mechanotransduction and in bone remodification and resorptions in some ways. It was found that mechanical stretches, such as hydrostatic forces and pulsating fluid flow, could increase the expressions of COX-2 mRNA and then prostaglandins, and activate many signal pathways in osteoblasts.

环氧合酶-2(cyclooxygenase-2，COX-2)以往被认为与炎症、肿瘤等有密切关系，近年研究发现它在骨骼重建、骨质吸收以及成骨细胞力学信号转导中发挥着重要作用，主要表现为机械牵拉、流体力、节律性液体流(pulsating fluid flow，PFF)等机械刺激均能引起成骨细胞COX-2高水平表达，进而引起前列腺素(prostaglandins，PGs)量的增加，激活成骨细胞内多条信号传导通路。

On the basis of the above study, we used COX-2 as the functional target point to observe therapeutic effects of selective COX-2 inhibitor on enteral and apenteric lesions of the FAP patients and analyze the clinical significance of selective COX-2 inhibitor in preventing and curing colorectal cancers.

同时以FAP为研究对象，分析COX-2基因在大肠肿瘤发生发展过程中的意义，初步探讨COX-2基因的表达调控机制。

Results］ the expression of cox-2 in hepatocellular carcinoma and its adjacent tissues with cirrhosis were 70.0% and 92.0% respectively, and they were higher than that in normal liver tissue (20.0%). the cox-2 expression in carcinoma adjacent tissues with cirrhosis was higher than that in hcc. expression of cox-2 in well differential hcc was higher than that in poor differential hcc, and higher in case with metastasis than that without metastasis(p＜0.01).the expression of cox-2 in hcc did not relate to tumor size, tumor capsula and the level of afp.

结果］ cox-2蛋白在hcc、癌旁肝硬化中表达阳性率分别为70.0%和92.0%，显著高于在正常肝组织中的20.0%（p＜0.05），而cox-2在癌旁肝硬化组织中的表达高于hcc组织。cox-2蛋白在分化好hcc中的表达显著高于分化差的hcc（p＜0.05），转移组中cox-2蛋白表达显著高于无转移组（p＜0.01）；而cox-2蛋白的表达与肿瘤大小、有无包膜及afp水平无关。

Expression of COX-2 in well differential HCC was higher than that in poor differential HCC, and higher in case with metastasis than that without metastasis(P＜0.01).The expression of COX-2 in HCC did not relate to tumor size, tumor capsula and the level of AFP.

COX-2蛋白在分化好HCC中的表达显著高于分化差的HCC（P＜0.05），转移组中COX-2蛋白表达显著高于无转移组（P＜0.01）；而COX-2蛋白的表达与肿瘤大小、有无包膜及AFP水平无关。

Despite evidence implicating prostaglandins as critical factor in male reproductive functions, little is known about expression and function of COX-2 in the male reproductive system. By using immunohistochemistry, RT-PCR and Western-blot, the content of this research included:(1) The expression and localization of COX-2 in mature rat and human testis were examined.(2) We investigated the changes of spermatogenesis and testosterone levels in testis after by using the COX-2 specific inhibitor-rofecoxib at 2, 4 and 8 weeks.(3) To explore the relationship between the intratesticular level of testosterone and expression of COX-2 by completely destroying the Leydig cells of mature male rats with injection of a single I.

本课题应用免疫组织化学、RT-PCR和Western-blot等方法检测以下内容：(1)在mRNA和蛋白水平检测正常成年男性及大鼠睾丸组织中COX-2的表达及定位情况；(2)实验组大鼠持续给予COX-2酶的特异性抑制剂Rofecoxib，分别于用药后2周、4周和8周检测大鼠的精子生成以及睾丸组织内睾酮浓度的变化；(3)另一组实验大鼠给予特异性Leydig细胞灭活剂EDS，在特定时间内抑制睾丸组织内合成的睾酮，于用药后2周和4周，采用免疫组织化学及RT-PCR方法观察大鼠睾丸组织内睾酮浓度变化对COX-2合成的影响。

Methods: immunohistochemical assay was used to detect cox 2 in 29 cervical cancer, 14 chronic cervitis and 18 normal cervixes. immunohistochemistry and in situ hybridization were used to detect the cox 2 protein and mrna in cervical cancer cell lines: siha and hela. the relationship between the expression of cox 2 and the clinicopathologic parameters of cervical cancer was analyzed.

用免疫组化方法检测29例宫颈癌患者cox 2的表达水平，并以14例慢性宫颈炎症患者和18例正常宫颈上皮为对照组；用免疫细胞化学方法和原位分子杂交法检测宫颈癌细胞株siha和hela中cox 2蛋白及基因表达。

The results showed that (1) COX-2 mRNA and protein existed in the mature male rat testis. COX-2 was localized in spermatocytes by immunohistochemistry.(2) COX-2 also existed in adult man testis. COX-2 protein was positively stained in spermatocytes and Leydig cells.(3) 2 weeks after administration of rofecoxib, the level of testosterone in the whole testis reached its lower values, being only 50% of control values. However, testosterone level recovered during 4 weeks. After such treatment, histologic examination of these testes showed atrophy of the seminiferous tubules and maturation arrest of spermatogenesis.(4) 2 weeks post-EDS, expression of COX-2 decreased significantly (P.005), in comparison with vehicle-treatment control. 4 weeks after treatment, a new generation of fetal like Leydig cells repopulated in the testicular interstitium resulting in COX-2 expression partially recovered. Although the expression of COX-2 mRNA and protein are enhanced at 8th week after using external testosterone, it wasn't significant higher than control group.

实验研究证明：(1)正常成年雄性大鼠睾丸组织中COX-2在mRNA和蛋白质水平均存在表达，免疫组织化学结果显示COX-2定位于曲细精管内的生精细胞；正常成年男性睾丸组织中同样存在COX-2表达，免疫组织化学结果显示COX-2定位于曲细精管内的生精细胞和Leydig细胞；(2)服用特异性COX-2酶抑制剂rofecoxib 2周后，实验组大鼠睾丸组织内睾酮的含量减少，为正常对照组的50％；持续用药4周后睾丸组织内睾酮浓度逐渐恢复至正常水平；COX-2酶活性降低后病理组织切片显示睾丸内曲细精管萎缩，生精紊乱，持续用药4周时影响最明显；(3)注射特异性Leydig细胞杀灭剂EDS 2周后，实验组大鼠睾丸组织内睾酮浓度降至极低水平时，COX-2的蛋白和基因表达水平也显著低于正常空白对照组（P.005）；使用EDS后第4周，睾丸组织中的睾酮浓度逐渐回升，同样组织中COX-2蛋白表达和mRNA表达水平也相应提高接近正常水平；使用EDS后4周开始给予外源性睾酮，6周和8周时COX-2表达水平的绝对值虽有提高，但与正常大鼠空白对照组比较并无显著性差异，说明外源性雄激素刺激睾丸合成COX-2的作用并不明显。

Results: COX-2 and VEGF levels in prostate cancer were much higher than those in BPH;the degree of cancer malignant and invasion positively correlated with the expression of COX-2 and VEGF;COX-2 level positively corr...

结果：前列腺癌组织中COX-2和VEGF的阳性表达均明显高于BPH；COX-2和VEGF在前列腺癌中的表达水平与其病理分级和临床分期均呈正相关；前列腺癌中的COX-2表达水平和VEGF的表达水平呈正相关。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。