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In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.
综合全部实验结果,本研究提示:夏季和低龄是托吡酯引起泌汗障碍的主要危险因素,而托吡酯剂量对泌汗功能的影响较小;托吡酯可以抑制小鼠汗液的分泌,小鼠的年龄并不影响这种抑制作用,但托吡酯对小鼠体温无明显影响;托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗;托吡酯不影响汗腺形态及Na,K-ATP酶活性;汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关,而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。
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The biggest contributor to the PA last year was the Arab League, which gave $448 million.
最大的贡献者向巴勒斯坦权力机构去年是阿拉伯联盟,提供了四万四千八点零零零万美元。
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He also is a frequent contributor to various trade publications on topics related to Web site and architectural design psychology and trends.
他还经常是各捐助国贸易相关议题的出版物和建筑设计心理学网站和趋势。
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The present study demonstrates that sudden arrhythmic death is an important contributor to SIDS.
本研究指出,突然的心律失常性死亡在SIDS中占很重要的地位。
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He writes about Chinese and South Asian politics, business and international diplomacy, and he is a regular contributor to the China Blog on TIME.com.
他主要报道中国和南亚的政治、商业和国际外交,他也在TIME.com的中国博客上发布文章。
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Fellow Bleacher Report contributor William Smith wrote a very popular article in which he stated his case for Kobe Bryant deserving this year's MVP award.
Bleacher Report的撰稿人同事威廉姆斯密斯曾写了一篇很受欢迎的文章,文中他表明了认为科比应该获得今年MVP的观点。
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The growing tendency to burn the candle at both ends may be a significant contributor to the current epidemic of diabetes.
日益严重的趋势,烧蜡烛两头可能是一个重大贡献者,以目前流行的糖尿病。
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But we are still by all odds the largest contributor.
但我们仍然是最大的"贡献者"
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The cease-fire is seen as a major contributor to the reduction in violence in Iraq over the last year.
这项方案被认为是去年伊拉克暴力减少的一个主要因素。
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China is a very important market for Celanese. It is a key link in our global business strategy and a significant contributor to our growth and development.
对塞拉尼斯而言,中国的重要战略意义不仅在于它是我们全球发展战略上的关键一环,同时也是公司未来发展的重要动力。
- 推荐网络例句
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On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.
另一方面,更重要的是由于城市住房是一种异质性产品。
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Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.
气候直方图是将所收集的降水量测定值,分为几个相等的区间作为横轴,并将各区间内所测定值依所出现的次数累积而成的面积,用柱子排起来的图形,也叫做柱状图。
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You rap, you know we are not so good at rapping, huh?
你唱吧,你也知道我们并不那么擅长说唱,对吧?