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Several anti-tumor cell lines and carbonic anhydrase Ⅱ model were established. More than 10000 compounds and extracts from plants were screened using these models and about 10 compounds showed strong inhibitory activities. Two species of plants Inula helianthus-aquatica and Saussurea deltoidea were chosen to investigate chemical and bioactivity constituents based on the results of screening of extracts and fractions. 58 compounds were isolated and identified from these two plants, 6 compounds were found to be new and 14 compounds showed anti-tumor activities. We also studied the anti-tumor mechanism of the compound bigelovin isolated from Inula helianthus-aquatica. Bigelovin was found with apoptotic activity against cell line U266 by lowering the amount of important transcription factor E2F-1 which inhibits the cell cycle at G0/G1 stage. Docking study on 7 natural new phenolic inhibitors of CA Ⅱ and 3D-QSAR study on 61 sulfonamide inhibitors of CA Ⅱwere also investigated. The calculated results were in good correlation with experimental results.

基于以上两种重要疾病和研究组方向，本论文工作开展了多个肿瘤细胞株和碳酸酐酶Ⅱ靶标模型的建立和筛选工作，累计筛选1万多个/次样品，发现10余个活性较强化合物；从粗提取物筛选结果中选取两种抗肿瘤活性强的菊科植物水朝阳旋覆花(Inula helianthus-aquatica)和三角叶凤毛菊进行了系统化学和活性成分研究，分离鉴定了58个化合物，发现6个新化合物和14个抗肿瘤活性化合物；通过合作对水朝阳旋覆花中活性较强的bigelovin进行了抗肿瘤作用机制研究，发现它可能是通过降低G2期重要的转录因子E2F-1，致使细胞周期阻滞在G0/G1期，引起多发性骨髓瘤U266细胞凋亡；开展了7个新的天然酚类CAⅡ抑制剂的对接研究和61个合成的系列磺酰胺类CAⅡ抑制剂的3D-QSAR分析，结果表明计算与实验一致。

Objective: To identify five constituents in the aqueous extract of Isatis indigotica Fort .

目的：鉴定大青叶水提液中的化学成分。

Objective To isolate and identify the chemical constituents in leaves of Isatis indigotica Fort.

摘要目的对十字花科植物菘蓝（Isatis indigotica Fort。

Berberine, one of the main constituents of the plant Rhizoma coptidis, is a type of isoquinoline alkaloid, reported to have anticancer effects in different human cancer cell lines.

黄连素是黄连主要的结构，是一种异奎啉类生物碱的型式，报告指出在不同的人类癌细胞有抗癌作用。

A comparison study of constituents of the absolute extracted from flower of Jasminum sambac by supercritical CO 2 and petroleum ether was made using GC and GC MS.

利用 GC和 GC- MS联用仪对超临界 CO2 萃取茉莉浸膏的净油进行化学成分分析，分离出 131个组分，鉴定出其中的 35个化合物，所鉴定的成分占分离成分的 85%以上。

Object:To study the chemical constituents in the green peel of Juglans Mandshurica.

目的：研究中药核桃楸青果皮的化学成分。

The result showed all the characteristic absorption peaks of hydroxyl-naphthaoquinone in the FT-IR spectrum of the product. The constituents of the product were determined by GC-MS to be: 1, 4-naphthaoquinone, 5-hydroxy-1,4-naphthaoquinone and 7-methoxy-1-tetralone, and the content of juglone in the product was 96.42%. The structure of juglone in the product was confirmed by 1H NMR. This study offered a simple and effective method to get high purity juglone from bark of J. mandshurica.

分别用FT-IR表征了产品的有机官能团、用GC-MS分析了产品的化学组成和产品中胡桃醌的相对含量（GC含量达96.42%）、通过1H NMR确认了产品的胡桃醌结构本研究提供了一种从核桃揪树皮中简便快捷地提取制得高纯度的胡桃醌产品的方法。

PartⅢStudy on the chemical constituents of Juniperus SabinaJuniperus Sabina is groveling shrub plant from Cupressaceaed,and distribut in Xinjiang,Qinghai and Gansu region,China.S.vulgaris has effect of dreving wind and sedation,promoting blood circulation to stop pain,and treat rheumatic arthritis, difficult urination etc.

第三部分新疆圆柏化学成分及生物活性研究新疆圆柏Juniperus Sabina L，又名沙地柏，为柏科Cupressaceae常绿匍匐灌木，主要分布于我国的新疆、青海、甘肃等地，药用果实和枝叶，具有驱风镇静、活血止痛之功效，维吾尔族民间用于风湿性关节炎、小便不利等病症的治疗。

Objective the chemical constituents of the ethyl acetate extract of Lagerstroemia reginae Roxb, Lagerstroemia calyculata Kurz and Lagerstroemia floribunda Jack were studied in this research.

目的：本研究对大叶紫薇、副萼紫薇和多花紫薇乙酸乙酯萃取部分的化学成分进行研究。

Objective To investigate the chemical constituents of Lappula echinata and determine the antibacterial activity.

目的 对东北鹤虱的化学成分进行分离和结构鉴定并进行抗菌活性测定。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。