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They have been shown to control cell growth, differentiation and apoptosis; consequently, impaired miRNAs expression has been implicated in tumorigenesis. Recently evidence indicates that patterns of misexpression of miRNAs in cancer suggest key functions of miRNAs in tumorigenesis.

很多研究报告指出特定的miRNAs在特定的肿瘤细胞中扮演重要角色，例如：miR-221与miR-222会负向调控p27Kip1而促进PC3前列腺癌细胞增生，因此，如果将miR-221与miR-222的表现抑制掉或是降低，就可以造成PC3细胞的增生减缓。

The mixotrophic culture of extreme halotolerant D.viridis improved the biomass of algae greatly and brought forwards the exponential period of algae,consequently it shortened the time,increased the production, decreased the manufacturing cost,strengthened our product competition in the international market and obtained considerable economic and social benefits.

混合培养能大大提高藻的生物量使藻提前进入生长指数期，缩短培养时间，增加产量，大幅降低产品成本，增强绿色杜氏藻的国际市场竞争力，从而会取得可观的经济效益和社会效益。

The following Ju and Moism made the situation more serious. Consequently, the people were at a loss: they were happy at the time when they should not; they were angry at the time when they should not. Their moods, such as happiness, anger, sadness and joy, were disordered.

紧跟的儒家及墨家更是变本加利，结果弄得人心大乱，不该高兴的时候高兴，不该生气的时候生气，喜怒哀乐的情绪都被搅乱了。

In light of the literatures in the recent years on anoxic pulmonary hypertension treated by Chinese medicine,Chinese medicine had selective hypotensive effect on pulmonary circulation and little effect on systemic circulation,consequently resulted in positive cardiac myodynamia and did no harm to blood gas.Thus Chinese medicine had better applied prospect and potential developmental value.

从近年来中医药治疗缺氧性肺动脉高压的文献报道看，中医药对肺循环有选择性降压作用，对体循环的影响较小，有正性心脏肌力作用，对血气无不利影响，中医中药有较好的应用前景和潜在的开发价值。

Consequently, clinicians should always consider nonadherence when topical therapies fail.

因此，当局部治疗失败时，临床医师应始终考虑到非依从性。

Fourth, it conducts the formula deduction, analysis and numerical calculations of the noncollinear quasi-phase matching gains and the output parametric spectrum, which leads to the conclusions that under the same circumstances, the gains of noncollinear interaction will be much less than those of the collinear interaction, and consequently the noncollinear interaction possesses the larger acceptance bandwidths than that of the collinear interaction.

对非共线准相位匹配的增益和输出参量光的允许波长进行了公式推导、分析和计算，得到了允许信号光波长的精确公式和关系曲线。

As for the mesh screen type, its volume multiplied by 100% its porosity was the desirable filling amount. Having considered the forgoing findings, the researchers add up the amounts of the above two types as the filling amount of the composite micro structure, with the filling fluid being acetone. In fabricating the heat spreader, a copper pipe is added to serve the filling purpose. What is more, because the manufacturing process is not carried out in a totally clean environment, there is some noncondensible gas left, which will have a negative effect on the performance of the heat spreader. Consequently, the copper pipe has to be reserved so that the exhaust gases can be evacuated after the filling is done.

Kempers 文中可知，沟槽结构之填充量以微结构体积之80%为最佳，网格结构则是以网格体积乘上孔隙率(porosity，φ)之100%为最佳，故本研究便以两者之加总做为复合式微结构之填充量，填充液为丙酮；在均温基板之制造程序中，会加装一铜管做充填之用，且而由于制造过程并非于一完全干净之环境下完成，故板内会有一些不利于均温基板作用之非凝结性气体noncondensible gas (NCG残留，因此铜管需保留一定的长度，以方便充填完成后将废气排出之用。

It provides the data commuication with integrity, confidentiality, authenticity and nonrepudiation. Consequently, secure network communication can be ensured by identifying the two parties involved in the communication.

数字签名为数据提供完整性、匿名性、身份识别和认证、以及不可否认性等安全服务，保证了网络中通信双方信息的安全传输。

Through adding new state variable and using supplement functions,the problem with restriction conditions was converted into nonrestriction problem.In addition,the dynamic searching method of optimal step coefficient was developed to modify the conventional gradient method,consequently the calculation problem of the multivariable optimal periodic control was able to be resolved better.

通过增加新的状态变量和用补偿函数法，将本课题的有约束条件问题化为无约束条件问题，并提出了最优步长参数的动态搜索法来修改传统的梯度法，从而较完善地解决了多变量最优周期控制的计算问题。

Consequently, we have to test whether the variables are nonstationary and then cointegration in a system.

因此，我们首先必须检验系统中变量的平稳性与协整性。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了