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The existence of dextran sulphate to the native ovalbumin leads to decrease about 60％ in fluorescence intensity following high pressure treatment. Complexation of polysaccharide with ovalbumin seems to protect the protein against pressure induced conformational change and aggregation; The presence of τ-carrageenan in glycinin solution is also found to protect the protein against pressure.

经超高压处理后，加入硫酸右旋糖苷的鸡蛋清蛋白溶液中的ANS荧光强度显著降低，降低约60％；这表明，硫酸右旋糖苷的加入可以和鸡蛋清蛋白相互作用，从而在超高压处理中起到稳定蛋白质天然构象的作用；对于大豆豆球蛋白溶液而言，ι-角叉菜胶的加入有维持高压下大豆豆球蛋白构象稳定性的作用。

Density functional theory study on conformational conversion between crystal conformation and cctive conformation of herbicidal monosulfuron.

单嘧磺隆除草剂的晶体构象-活性构象转换的密度泛函理论研究。

The conformational spaces of a protein are huge, and chances are rare that any heuristically generated structures will directly fall in the neighborhood of the native structure.

蛋白质摺叠的结构范围相当广阔，直接利用计算方法产生出类似自然结晶结构的结构有相当的难度；在理想的情况下，非自然的摺叠结构或许可以提供相当的助益，利用非自然的摺叠结构来修正计分函式或能量函式，并利用修正过后的计分函式或能量函式来分辨出自然和非自然的结构，也许是个可行的方法。

We have investigated the conformational features of four short peptide fragments of Staphylococcal nuclease by homonuclear two-dimensional NMR and circular dichroism with a view to examining the early events in the folding process of SNase.

本论文工作用四个金黄色葡萄球菌核酸酶N-末端短片段作为新生肽链折叠的模型，用同核二维核磁共振谱和远紫外圆二色谱研究了它们的溶液构象特征。

We have investigated the conformational features of four short peptide fragments of Staphylococcal nuclease by homonuclear two-dimensional NMR and circular dichroism with a view to examining the early events in the folding process of SNase.

中文题名金黄色葡萄球菌核酸酶折叠起始位点：N-末端短肽段的NMR研究副题名外文题名 Folding initiation sites of staphylococcal nuclease：exploring the solution conformation of N-terminal fragments by nuclear magnetic resonance 论文作者戴继勋导师王金凤研究员学科专业分子生物学研究领域\研究方向学位级别博士学位授予单位中国科学院生物物理研究所学位授予日期2001 论文页码总数68页关键词金黄色葡萄球菌核酸酶蛋白质折叠核磁共振馆藏号BSLW /2001 /Q71 /89 本论文工作用四个金黄色葡萄球菌核酸酶N-末端短片段作为新生肽链折叠的模型，用同核二维核磁共振谱和远紫外圆二色谱研究了它们的溶液构象特征。

Oxidation of amino acid residues results in conformational changes and exposure of hydrophobic residues at the protein surface.

氧化的氨基酸残基，结果在构象变化，并有更多机会接触疏水残留在蛋白质表面。

Based on our intensive studies on the lactonization of oligo/polysialic acids, we proposed for the first time that the lactone-ring formation of oligo/polysialic acids has three stages. We also provided a novel model to explain the conformational changes of oligo/polysialic acids caused by the repulsing forces among the carboxyl groups of sialic acid residues. Our results should provide novel approaches for further investigation of the structural-functional relationships of oligo/polysialic acids.

在对多/寡聚唾液酸内酯化过程进行深入研究的基础上，于国际上率先提出多/寡聚唾液酸内酯的形成具有三个阶段的观点，并首创性地提出了羧基排斥所致多/寡聚唾液酸分子空间构象改变的模型，为深入研究多/寡聚唾液酸结构与功能的关系提供了新生长点。

Effects of perturbing various model parameters on the equilibriums between native-like states with other conformational states were considered.

我们考虑扰动不同力场参数对天然态和其它构象态之间平衡的影响。

We predict the optimized structures of macrocyclic ligands of cyclononane and cyclododecane systems in different environments; furthermore, we analyze the protonated sites, preorganization, conformational changes and calculated energies.

利用此模拟方法，我们针对不同环境下之九员环以及十二员环系列的大环配位子进行结构最佳化之预测，进而可分析 protonation sites 、配位子是否会发生 preorganization 与结构的变化，以及能量的计算。

In this review, we focus on such protein conformational disorders and on the role that altered function of intracellular proteolytic systems, in particular autophagy, plays in the evolution of these diseases.

在这回顾中，我们集中在上述的蛋白质的构象无序和细胞内的蛋白水解系统功能改变的作用，特别自噬，在疾病演变的作用。

Plunder melds and run with this jewel!

掠夺melds和运行与此宝石！

My dream is to be a crazy growing tree and extend at the edge between the city and the forest.

此刻，也许正是在通往天国的路上，我体验着这白色的晕旋。