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The difference of fluorescence quenching between light-adapted and dark-adapted bacteriorhodopsin showed this quencher can be used in the study of conformational change of Biomembrane proteins.

竹红菌乙素对明暗适应菌紫质荧光猝灭的差别，说明这种猝灭剂可用于生物膜体系的蛋白质构象变化的研究。

Mainly using protein - film voltammetric technique, we have achieved direct electrochemical response of lots of proteins such as hemoglobin, myoglobin, cytocrome c, cytocrome b5, horseradish peroxiase, GOD ,Vitreoscillia sp. haemoglobin, etc., at a series of protein membrane modified electrodes, for instance, protein/kieselgubr, protein/polyethylene glycol, protein/polyethyleneimine, protein/phosphatidylcholine, protein/DNA, protein/montmorillonite/polyvinyl alcohol, protein/silver nanoparticle/ cysteamine membrane modified electrode, etc., which are prepared by casting, incorperating or layer by layer self-assembly methods. Electrochemical behavior of these proteins in the films have been studied, and their structural and conformational changes have also been examined with spectrometric techniques.

三年来，在基金委的支持下，我们以蛋白膜伏安法这一新技术作为主要的研究手段，并结合其他生物、化学技术，研究了血红蛋白、肌红蛋白、细胞色素C、细胞色素b5、辣根过氧化物酶、葡萄糖氧化酶以及好氧革兰式阴性菌透明颤菌中的血红素类蛋白等多种蛋白质在以涂布和自组装方法制成的蛋白质/硅藻土膜、蛋白质/聚乙二醇膜、蛋白质/卵磷脂膜、蛋白质/聚乙烯亚胺膜、蛋白质/蒙托石/聚乙烯醇自组装膜以及蛋白质/银胶/半胱胺自组装膜等修饰电极上的直接电化学行为，结合各种光谱技术，对蛋白质在膜中的构象进行表征，探索其电子传递机理。

The conformational variation of a polymer chain terminally attached to a surface at different temperatures was studied by using Monte Carlo and simulated annealing methods.The model polymer chain was a self-avoiding walk with non-bonded nearest-neighbor interactions on a simple cubic lattice.

借Monte Carlo和模拟退火方法研究了端基附壁高分子尾形链在不同温度下的形态变化，链的模型采用有最近邻相互吸引作用的自避行走。

It is feasible to indicate the conformational changes by the exposed speed of thiol buried with DTNB when the pH is changed.

在pH变化时，利用DTNLB测定CK内埋巯基的暴露来反映构象的变化是成功的。

The theoretical model of molecular interaction was researched by conformational analysis of trehalose through computer software.

利用计算机软件，开展了亲和作用的分子模型和动力学方面的理论研究。

According to the spetial conformational analysis and physical/chemical property analysis and by the aid of computer it can make molecular design of mimic polypeptide and designs the polypeptide molecule with activity for neutralizing LPS, and adopts the solid phase polypeptide chemical synthesis method to synthesize antibacterial/antiendotoxin mimic peptide with total or partial BPI bio-function.

本发明公开了通过计算机模拟设计、人工合成的66个抗菌／抗内毒素模拟肽，根据对BPIN端三个LOOP区的空间构象分析及物理化学性质分析，在计算机辅助下进行模拟多肽的分子设计，设计出具有中和LPS活性的多肽分子，用固相多肽化学合成方法合成抗菌／抗内毒素模拟肽，本发明的抗菌／抗内毒素模拟肽具有全部或部分BPI的生物功能，可以用于治疗G－细菌感染、人内毒素血症，具有分子量小、可以稳定重复生产的特点。

DFT were carried out to optimize the conformational isomers with minimum energies. Peak separations in the methyl and azomethine signals were also found to originate from the rotation hindrance of the N-N bond. After N'-acylideneacetohydrazides were converted to 1, 3, 4-oxadiazole compounds, the proton signal of the methyl group appeared as a single peak.

端甲基质子和次甲基质子信号裂分也来源于N-N键旋转受阻。N'-苄基酰腙通过缩合反应转变成1，3，4-二唑化合物，消除了甲基空间取向的差异，其信号变为单峰。

Therelative rates of the Rh-mediated carbenoid insertion into the benzylic C - H bonds of aseries of para-substituted phenyl substrates: methyl 2-diazo-3-oxo-6-(4-substituted phenyl)-4-propylhexanoate 47a - g, have been measured by an indirect intramolecular competitionmethod under the condition in which the possible steric and conformational effects have beenminimized.

为了将立体因素和构象因素最大程度减小，以便较为准确地评价电子效应对该反应的影响，设计并合成了不同对位取代基的化合物4-丙基-6-(4-取代苯基)-2-重氮基-3-氧代己酸甲酯47a-g，并研究了它们在不同Rh催化剂作用下的分子内C-H插入反应。

The screening was carried out by single strand conformational polymorphorsim : the PCR product precipitation was dissolved in 20μl denaturing and loading buffer (95%+20mMEDTA+ 0.05% bromophenol blue+0.05% xylene cyanol), heat-denatured in 95 ℃ to two single DNA strands.

通过单链构象多态性分析筛查RDS基因突变；沉淀回收的PCR产物以20μl变性上样液（95%甲酰胺+20mMEDTA+0.05%溴酚蓝+0.05%二甲苯蓝）溶解后热变性为两条DNA单链后，上样于8%非变性聚丙烯酰胺凝胶（含5%甘油），700伏电压、4℃电泳16小时。

We suggest the low enzymatic activity of these mutants is due to the conformational change.

因此，我们认为这些突变株的低水解活性是由於其蛋白构型改变所导致。

Plunder melds and run with this jewel!

掠夺melds和运行与此宝石！

My dream is to be a crazy growing tree and extend at the edge between the city and the forest.

此刻，也许正是在通往天国的路上，我体验着这白色的晕旋。