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The results showed that the D50 of Astragalus membranaceus and Epimedium brevicornum ultra-fine powder were 6.82μm and 8.40μm separately. The broken cellular walls of two ultra-fine herbal powder were bigger than those of the commonly cribble, and intact cells were not visible under SEM, and it improved the mixed uniformity. On the contrary, organization blocks of the commonly cribble were clearly discernible, also the shape and granularity were irregular, and the organization cells were still complete. The bulk density and liquidity of Astragalus membranaceus and Epimedium brevicornum increased significantly after ultra-fine Smashing. The component icariin extraction content of the ultra-fine powder was enhanced by 18.31% compared with the cribble by the chromatograph analysis of icariin. At the same time, Astragalus membranaceus polysaccharide and Epimedium brevicornum polysaccharide content of the ultra-fine powder were enhanced by 117.13% and 315.15% compared with the cribble.

结果发现黄芪和淫羊藿经超微粉碎后，粉体的粒度分布中心D_(50)分别为6.82μm和8.40μm，经电镜观察均难以看到完整的细胞形态，只能看到细胞碎片，破壁率远远大于普通粗粉，其混合的均匀度显著提高，而普通粗粉在显微镜下，组织块清晰可见，且形状不规则，粒径分布不均匀，组织细胞仍然完整；超微粉碎后，黄芪和淫羊藿的堆密度和流动性显著增强；通过对淫羊藿有效成分淫羊藿苷的色谱分析，其中淫羊藿超微粉的淫羊藿苷体外溶出量较淫羊藿粗粉中提高了18.31%；同时黄芪、淫羊藿超微粉多糖的提取率分别较黄芪、淫羊藿粗粉提高了117.13%，315.15%。

Results: Tyroserleutide can significantly increase the life span of H22 tumor-bearing mice by 50-70% in dosages of 20ug/kg/d-80ug/kg/d,specially the high dosage of 80ug/ml can significantly increase the life span by 69.24%; Tyroserleutide can inhibit the growth of transplanted hepatocellular tumor BEL-7402 in nude mice,the rate of tumor inhibition was25-50% in dosages of 40-320ug/ml ,the inhibition rate of 160ng/ml was 44.03%; Tyroserleutide could inhibit the growth of H22 and BEL-7402 tumor in a dose-dependent manner. Simultaneously, tumoricidal activity of tyroserleutide against BEL-7402 cell line in vitro was observed hinger when compared with the control group(P.05).The inhibition effect of 72hrs was higher than 24hrs,48hrs,96hrs.And specially the high dosage of 160ug/ml can significantly inhibit growth of tumor cell by 19.36%. Tyroserleutide can activated PEM and marked enhance cytotoxicity andphagocytosis functions in vitro and in vivo. The OD values of cytotoxicity were observed hinger when compared with the control group(P.05).The cytotoxicity of macrophages activated by tyroserleutide against BEL-7402 and B16-F10 was 35.58%,61.2% in vitro and21.39%,47.63% in vivo. The cytotoxicity rate of nude mice PEM was 32.86%,73.07% in vivo. Furthermore, tyroserleutide alone could stimulated the production of IL-1B TNF- a and NO by M . Tyroserleutide and LPS could synergistically activated M producing more cytotoxicity effectors. Conclusion: Tyroserleutide had inhibition functions against hepatoma carcinoma .Its possible mechanisms were related to the affect that Tyroserleutide could inhibit tumor cell directively and induce tumor cells apoptosis or death effectively.

结果：酪丝亮肽能显著延长腹水型肝癌H_(22)小鼠的生存时间，给药剂量为80μg／kg／d时疗效最显著，达到69.24％，在20μg／kg／d-80μg／kg／d剂量范围内生命延长率为50-70％，给药剂量与荷瘤鼠生存时间呈现一定量效关系；酪丝亮肽能显著抑制人肝癌BEL-7402移植瘤裸鼠的肿瘤生长，给药剂量为160μg／kg／d时疗效最显著，抑制率为44.03％，并且在40-320μg／kg／d剂量范围内抑制率为25-50％，给药剂量与肿瘤抑制率呈现一定量效关系；酪丝亮肽体外对人肝癌BEL-7402细胞生长有一定的抑制作用，在作用72hrs时各浓度酪丝亮肽对肿瘤细胞的抑制作用较24hrs、48hrs、96hrs明显，其中浓度为100μg／ml时抑制率达19.36％；酪丝亮肽体内外均能增强小鼠腹腔巨噬细胞对肿瘤细胞的杀伤：体外作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强，与效应细胞对照组相比有显著性差异(P＜0.05)杀伤率分别达到35.58％、61.2％；体内作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强，与生理盐水对照组相比有显著性差异(P 。05)，杀伤率分别达到21.39%、47.63%；裸鼠腹腔巨噬细胞经酪丝亮肤作用后对BEL一7402、B 16一F10杀伤功能明显增强，与生理盐水对照组相比有显著性差异(P.05)，最高杀伤率分别达到32.86%、73.07%；酪丝亮肤能增强单核巨噬细胞系统的吞噬功能，吞噬指数与生理盐水组比较有显著性差异(P.05)；酪丝亮肤体外作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO，与效应细胞对照组相比有显著性差异(P.05)；酪丝亮肤体内作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO，与生理盐水对照组相比有显著性差异(P.05)；酪丝亮肤能促进鼠巨噬细胞株R戌W264.7分泌合成IL一1p和NO，IL一1日、NO水平分别在酪丝亮肤作用24hrs、12hrs时达到高峰，酪丝亮肤单独应用能提高巨噬细胞的分泌合成功能，而且酪丝亮肤能与LPS协同作用刺激巨噬细胞的细胞毒效应分子分泌合成。

Results the weight was increased significantly in OVX rats as compared with normal group(P. 05). As compared with the OVX group, the weight in the nilestriol group, water pharmaceutical preparation of drynaria group,ethanol pharmaceutical preparation of drynaria group were decreased P.

结果：模型组与正常对照组大鼠比较体重显著增加(P＜0.05)；与模型组比较，尼尔雌醇组体重降低(P＜0.05)；骨碎补水提、醇提组体重降低，差异有显著性(P＜0.05)；与正常对照组相比，骨碎补水提、醇提组均无显著性差异(P＞0.05)。

At endpoint, every cardiac function parameter in group MSCs and TXL was not significantly different compared with group control (all P＞0.05), however, the number of dyskinetic segments (P=0.039) and infarcted size (P=0.0061) in group simvastatin, and the number of dyskinetic segments (P=0.04) in group atorvastatin, were remarkably decreased compared with group control.

终点时，MSCs组、通心络超微粉组和对照组无显著差异(47.3±13.2％，44.8±13.9％vs 47.8±11.1％，P＞0.05)，而辛伐他汀组和阿托伐他汀组灌注缺损面积均小于对照组(39.3±12.4％，38.7±13.1％vs47.8±11.1％，P＜0.05)；尤其是通心络超微粉+MSCs组、辛伐他汀+MSCs组、阿托伐他汀+MSCs组的灌注缺损面积进一步显著减小(27.6±7.4％，28.3±7.7％，29.3±9.0％vs 47.8±11.1％，P＜0.05)。

Results : Learning disorder and dysmnesia were obvious in the model group as compared with the control group as compared with the control group.

结果：与对照组比较，模型组大鼠学习记忆明显障碍，眼针组、尼莫通组学习记忆能力明显改善，与模型组比较（P〈0.01）。

In the HDT 30th day, the maximal exercise time in control group and limb muscular group decreased significantly (P.05), but in bicycle ergometric group did not reach significance compared with pre-HDT and increased significantly (P.05) compared with control group and limb muscular group.

卧床第30 d，对照组和下肢肌力训练组的最大运动时间较卧床前显著降低(P.05)，而自行车功量计训练组较卧床前无明显变化，且较对照组和下肢肌力训练组显著升高(P.05)。

The results showed that in the HDT 30th day, the orthostatic tolerance decreased significantly (P.01) in control group compared with pre-HDT, but in the limb muscular group and bicycle ergometric group, the orthostatic tolerance decreased insignificantly compared with pre-HDT.

结果发现：卧床第30 d，对照组的立位耐力较卧床前显著降低(P.01)，而下肢肌力训练组和自行车功量计训练组的立位耐力较卧床前有所降低，但未达到显著水平。

Compared with pre-HDT, body weight trended to decrease in control group and increase in limb muscular group, but had no significant changes in bicycle ergometric group during HDT; in the HDT 10th day, body weight increased significantly (P.05) in limb muscular group compared with bicycle ergometric group.

卧床期间，对照组体重较卧床前有降低趋势，下肢肌力训练组有升高趋势，自行车功量计训练组无明显变化；卧床第10 d，下肢肌力训练组体重较对照组显著增加(P.05)。

Results: Compared with sham operation group, the ability of vascular dementia model mouse for learning and memory reduced, which showed extending the time for swimming the whole process, and increasing times of mistakes, and the activity of SOD in hippocamp was decreased and the content of MDA was increased(P.01). Compared with model group, Danggui Shaoyao-San could make the time for swimming the whole process shorten and times of mistakes decreased, and increase the activity of SOD and decrease the content of MDA in hippocamp, which were excellent than that of contrast medicine.

结果：与假手术组比较，模型小鼠学习与记忆能力下降，表现为游全程时间延长，错误次数增加(P.01)，脑海马SOD活性明显降低，MDA含量明显升高(P.01)；与模型组比较，当归芍药散组可使游全程时间缩短，错误次数减少，脑海马SOD活性明显升高，MDA含量明显降低(P.01)，并优于对照药物(P.05)。

Months later, BMD in Sham and OVX-2 were (1.22±0.07)g/cm2 and (0.86±0.09)g/cm2. BMD in OVX-2 decreased by 29.5% compared with that in Sham group. Histomorphologically, trabecular bone decreased significantly in OVX-2 group compared with that in control groups.

组织学切片观察发现，去势12个月后，绵羊椎体松质骨骨小梁明显稀疏，局部存在骨小梁骨折及骨缺损，而对照组骨小梁结构完整，呈圆形或椭圆形拱形结构。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。