查询词典 collagen

The human cartilages are composed of chondrocyte and extracellular matrix , the form of chondrocytes are hypertrophy and the quantity are less; the ECM of cartilage are compised of type Ⅱ collagen and proteoglycan. Articular cartilages are all hyaline with little fibers. Trauma and arthritis are the main cause of cartilage injury, the ommilayer injury ofcartilage can be recovered by marrow, but because of without stimulation mechanism, the new tissues are merely fibrocartilages, they can not be coincide with hyaline cartilage in menchanics; the purely damage of articular cartilage can not stimulate chondrocyte to regenerate because of without blood circulation, thus, the plerosis of articular catilage can not depend on the proliferation of local chondrocyte. Ever since, people tried their best to find a way to reconstruct articular cartilage.

中文题名人骨髓基质干细胞成软骨诱导及多孔复合材料作为细胞载体的体外实验研究副题名外文题名 Cartilage induction of human mesenchymal stem cells and experiment on compound porous materials as cells' scaffold in vitro 论文作者刘晓岚导师周江南学科专业外科学研究领域\研究方向学位级别博士学位授予单位中南大学学位授予日期2003 论文页码总数68页关键词骨组织工程软骨细胞骨髓基质干细胞壳聚糖高分子外消旋聚乳酸馆藏号BSLW /2003 /R68 /10 造成人体关节软骨损伤的原因主要为创伤和关节炎，关节软骨全层损伤可由于骨髓中间充质干细胞的高速增殖修复，但这种修复由于缺乏相应的刺激机制，只能形成纤维软骨，而不能形成符合关节生理、力学要求的透明软骨；单纯软骨部分损伤软骨组织内无血管，软骨细胞迁移迟缓，无法使损伤区域软骨细胞再生，因此，关节炎及关节创伤后的软骨修复不能依赖于软骨细胞的增殖和迁移。

The mechanism of action maybe include the depression in content of collagen, inhibition to proliferation of lung fibroblast, action of anti free redical and anti lipid peroxidation, and elevation of content of GSH-PX.So we think phenol total base of plumula nelumbinis is a sort of promising drug to healing PF.

综上所述，我们认为莲子心酚性总碱可能对肺纤维化的病理过程有多靶点作用：前期通过抗自由基作用，从而减轻肺泡炎损伤：后期直接抑制肺成纤维细胞的增殖及蛋白沉积，减轻纤维化病变程度。

Finally, it was preliminarily to make use of compound enzyme in the collagen enzyme-degrading reaction.

最后，在对单酶的研究基础上，初步探讨了复合酶对骨胶原的酶解反应。

Results It showed that the prolabium of complete BCL had no muscle, there were only weblike collagen fibers of bundles of them, capillaries, fats and fats and fiber－blasts. There were muscle fibers in prolabium and bridges of incomplete BCL,but ultra structure variations were found. The prolabium of complete BCL operated on with straight line suture method had muscle fibers proliferated from the lateral lips, but the fibers were sparse and also had ultra structure variations.

结果 发现完全性双侧唇裂的前唇部无肌纤维，双侧不完全性唇裂的前唇及桥部有少量肌纤维，但其超微结构有变异；用直线缝合法修复的完全性双侧唇裂的前唇部，有从侧唇增生的肌纤维，但稀少，超微结构亦有变异。

Additionally, a homogeneous staining for collagen prolyl 4-hydroxylase and fibronectin was observed.

此外，极少的细胞表达CK-18或CK-19但未发现白蛋白阳性细胞。

Co-expression of collagen genes and cDNAs encoding the subunits of prolyl hydroxylase has lead to the synthesis of completely hydroxylated, thermostable collagens.

胶原基因和编码羟化酶亚单位的 cDNAs 的共表达已经可以使胶原完全的羟基化并耐热。

As seen in other recombinant expression systems, transgenic silkworms, tobacco, and mice lack sufficient endogenous prolyl hydroxylase activity to produce fully hydroxylated collagen.

如前所述，这些转基因系统本身缺乏羟化酶活性，但是同样可以生产出羟化胶原。

RESULTS: The extract of Aml could reduce the abnormally high levels of ALT and AST. Examined by light microscope , the degeneration and necrosis level of hepatocytes and the distribution of collagen fibrosis were markedly increased in the model group. The pathological changes and the c ollagen fibrosis associated with hepatic fibrosis decreased significantly in the prophylactically treated groups.

结果： 蓍草提取物预防给药能降低 CCl 4所致大鼠血清中异常增高的 ALT 、 AST 含量，光镜下观察肝纤维化模型组大鼠肝细胞严重变性、坏死，胶原纤维明显增加，蓍草预防各组大鼠肝细胞病理损伤得到明显改善。

In 29 cases, infiltrated regien tissue, scar-like collagen, surrounding soft tissue, envelope or vessel: frozen section to paraffin section 86.2%/96.6%, 100%/100%, 37.9%/41.4%, 13.8%/41.4% and 0.0%/10.3%, respectively. Referenced criteria line of psammoma bodies, necrosis and cells heteromorphism appeared in frozen section and paraffin section 62.1%/58.6%, 13.8%/10.3% and 37.9%/24.1% respectively.

主要指标为浸润局部组织、瘢痕样胶原、周围软组织、包膜或血管：冷冻切片与石蜡切片分别占86.2%/96.6%，100%/100%，37.9%/41.4%，13.8%/41.4%或0.0%/10.3%；辅助指标为沙砾体、坏死或细胞异型性：冷冻切片与石蜡切片分别占62.1%/58.6%，13.8%/10.3%或

RESULTS: HE stained cells were fusiform-shaped with pseudopodia, round or oval nucleus. The cytoplasm was blue after stained with the toluidine blue. The immunohistochemical test revealed that there existed positive expression of type Ⅰ collagen in the cells. In the presence of 10% calf serum, IGF-Ⅰ significantly improved cell proliferative activity in a dose-dependent manner within effective dose range.

结果：苏木精－伊红染色细胞多为梭形，有伪足伸出，细胞核为圆形或椭圆形；甲苯胺蓝染色，胞浆为深蓝色；免疫细胞学方法检测表明纤维环细胞有Ⅰ型胶原表达；在体积分数为0.1的血清条件下，胰岛素样生长因子Ⅰ能提高细胞的增殖活性，并且在有效浓度范围内呈剂量效应关系。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。