查询词典 cml.

Inclinical,CML has been divided into chronic period,acceleration period andblast period.Each period has distinct heterogenicity,and,extra variations ofchromosomes and genes emerge in blast period.

CML在临床上分为慢性期、加速期和急变期，它们在细胞遗传学及分子生物学上存在着较大异质性，在急变期常会出现额外的染色体和基因的变异。

Critically, the combination of a tyrosine kinase inhibitor, i.e., IM, nilotinib, or dasatinib, with inhibitors of autophagy resulted in near complete elimination of phenotypically and functionally defined CML stem cells.

关键的是，联合应用酪氨酸激酶抑制剂，如IM、尼洛替尼、达沙替尼和自噬抑制剂可几近全部消除表型及功能定义的CML干细胞。

A 1. 13kb part of the BCR promotor region was amplified and sequenced from 30 CML patients and 19 controls.

BCR基因启动子区用PCR方法扩增了1.13kb的序列范围，通过测序的方法获得了30例CML和19例对照的启动子区序列。

Previously, Dr. Mahon and colleagues conducted a pilot study and explored the feasibility of discontinuing imatinib in CML patients who had experienced a complete molecular response. Of the 15 patients included in the cohort, 7 relapsed within 6 months, but they were able to reattain a complete molecular response after imatinib was restarted. The other 8 patients remain in remission after the discontinuation of imatinib (median follow-up is 37 months).

之前，Mahon医师等人主导一个先驱研究，探索完整分子生物学上缓解之CML病患停用imatinib的可能性，在总共15名病患中，7人在6个月内復发，但他们可以在再度使用imatinib之后再度达到完整分子生物学上缓解，其他8个病患在停用imatinib之后持续缓解(平均追踪期为37个月)。

Previously, Dr. Mahon and colleagues conducted a pilot study and explored the feasibility of discontinuing imatinib in CML patients who had experienced a complete molecular response. Of the 15 patients included in the cohort, 7 relapsed within 6 months, but they were able to reattain a complete molecular response after imatinib was restarted. The other 8 patients remain in remission after the discontinuation of imatinib (median follow-up is 37 months).

之前，Mahon医师等人主导一个先驱研究，探索完整分子生物学上缓解之CML病患停用imatinib的可能性，在总共15名病患中，7人在6个月内复发，但他们可以在再度使用imatinib之后再度达到完整分子生物学上缓解，其他8个病患在停用imatinib之后持续缓解(平均追踪期为37个月)。

Previously, Dr. Mahon and colleagues conducted a pilot study and explored the feasibility of discontinuing imatinib in CML patients who had experienced a complete molecular response. Of the 15 patients included in the cohort, 7 relapsed within 6 months, but they were able to reattain a complete molecular response after imatinib was restarted. The other 8 patients remain in remission after the discontinuation of imatinib (median follow-up is 37 months).

之前，Mahon医师等人主导一个先驱研究，探索完整分子生物学上缓解之CML病患停用imatinib的可能性，在总共15名病患中，7人在6个月内复发，但他们可以在再度使用imatinib之后再度达到完整分子生物学上缓解，其它8个病患在停用imatinib之后持续缓解(平均追踪期为37个月)。

Methods Real-time quantitative retroverse polymerase chain reaction method was used for detecting RbAp46 expression levels in BM cells of 140 patients with acute leukemia,13 with chronic myelogenous leukemia in chronic phase, 7 with CML in blast crisis and 32 with non-leukemic disorders.

方法建立实时定量RTPCR方法，利用SYBRGreenⅠ染料检测140例急性白血病、13例慢性粒细胞白血病慢性期和7例CML急变期患者以及32例非白血病患者骨髓细胞RbAp46基因的表达水平。

The Third chapter analyses the chaos feature possessed by disequilibrium economy system in detail, reveals universality of economy chaos studies the problem of disequilibrium Economy system's foreost and control analysis economy's strategy management problem using chaos'principle of unexactness in measuring Meanwhile, this chapter introduces the CML model, which reveals of economy, and probes into the space-time chaos character of economy system.

第三章详细分析了非均衡经济系统所具有的混沌特征，揭示了经济混沌的普遍性；研究了非均衡经济系统的预测与控制问题；应用混沌的测不准原则分析了经济的战略管理问题。同时把揭示湍流规律的CML模型引入经济分析，探讨了经济系统的时空混沌特征。

Methods We detected c-Myc, Bcl-2 and Fas proteins and performed immunophenotyping by flow cytometry in 21 cases of CML marrows and 9 normal bone marrows.

采用流式细胞术，测定21例CML及12例正常骨髓标本单个核细胞的髓系免疫表型及三种与PCD有关的调节蛋白――c-Myc、Bcl-2、Fas的表达。

The different types of bcr/abl splicers were present in CML patients in phases and there may be a certain relevance of splicing and hematological parameters.

结论不同阶段CML患者体内大都存在着不同的bcr/abl剪切型转录本，不同剪切型的存在具有一定的血液学相关性。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。