查询词典 cisplatin

However, this contradicts other experiments that have demonstrated that treated tumor cells do not contain bare platinum, but rather undegraded cisplatin—accumulated in certain organelles.

其中就含有一些完整的顺式铂氨。小泡接着进入胞内，并且和包括细胞核在内的细胞器发生接触。

Methodsthe diuretic effect was studied by weighing method and metabolic cage to observe the urine volume of mice and rat;the emesis induced by both bluestone and cisplatin were studied by observing the incubation period of emesis of pigeon and the vomitive times of pigeon.

方法采用称重法和代谢笼法研究受试药对小鼠及大鼠的利尿作用；采用硫酸铜和顺铂致家鸽呕吐的模型，观察受试药的镇吐作用。

MethodsThe diuretic effect was studied by weighing method and metabolic cage to observe the urine volume of mice and rat;the emesis induced by both bluestone and cisplatin were studied by observing the incubation period of emesis of pigeon and the vomitive times of pigeon.

作者：崔桂梅，陈宝田，胡琼力，冯佳目的研究天麻止眩颗粒的利尿、镇吐作用。方法采用称重法和代谢笼法研究受试药对小鼠及大鼠的利尿作用；采用硫酸铜和顺铂致家鸽呕吐的模型，观察受试药的镇吐作用。

The cell cycle and apoptosis and the expression of P-pg, bcl-2, P53 in the MG63 and MG63/R cell lines were analyzed by flow cytometry. Results The resistance index of the MG63/R cells to cisplatin was 83.557±4.841. The cells also had resistance to doxorubicin, vincristin, methotrexate and cyclophosphamide. Disordered structure of the MG63/R cells was observed through microscopy. The cells appeared in triangle, polygon and polynucleation. The increase of granular endoplasmic reticulums and apophyses was observed through transmission electron microscopy. The proliferation ability of MG63/R increased significantly, with a low apoptosis index.

结果 经顺铂186d的诱导，建立了MG63/R，其对顺铂的耐药指数为83.557±4.841，对阿霉素、长春新碱、氨甲基蝶吟、环磷酰氨亦产生不同程度的交叉耐药；光镜观察可见MG63/R细胞排列不规则，形态呈三角形、多角形及多核现象；透射电镜显示MG63/R细胞表面突起增加，粗面内质网丰富；细胞周期分析显示细胞增殖能力明显增加而细胞凋亡明显降低；MG63/R细胞 P-pg、bcl-2阳性表达较MG63细胞明显增加，P53表达则明显降低。

AIM: To study the mechanism of cisplatin interaction with DNA, and the attenuating effects of 6,7-dimethoxycoumarin on crosslink .

目的：研究顺铂与肾近端小管DNA的作用机制，和茵陈素的干预作用，方法：原代培养兔肾近端小管细胞。

Radioactivity of 〓Tc-MIBI incepted by A549DDP cells in controlling group, Rh2 group, DDP group and Rh2＋DDP group account for 0.94%, 1. 08%, 1. 13% and 2. 0% respectively of the total radioactivity. There was evident difference between the former three groups and Rh2＋DDP group P＜(0.05 . Radioactivity of 〓Tc-MIBI incepted by A549 cells was 2. 38% of the total radioactivity, obviously higher than that in controlling group (P ＜O. 05). conclusions: gensenoside Rh2 of no toxicity concentration can reverse resistance of lung adenocarcinoma A549DDP cells to cisplatin.

对照组的A549DDP细胞摄取〓Tc-MIBI的放射性活性与总放射性活性的百分比为0.94%为，Rh2组的A549DDP细胞摄取〓Tc-MIBI的放射性活性与总放射性活性的百分比为1.08%，DDP组的A549DDP细胞摄取〓Tc-MIBI的放射性活性与总放射性活性的百分比为1.13%，这两组分别与对照组比较无显著性差别（P＞0.05）；Rh2+DDP组的A549DDP细胞摄取。

Metformin can inhibit the growth of lung adenocarcinoma cell lines significantly and potentiate cisplatin in a dose- and time-dependent manner in vitro. Cell-cycle progression is arrested in G1 stage and apoptosis is indued after metformin treatment.

二甲双胍可以使细胞周期循环阻滞于G1期，并诱导细胞的早期凋亡增加，从而有效抑制肺腺癌细胞株的体外增殖，其作用呈浓度及时间依赖性增强；二甲双胍与顺铂共同作用可以增强对肺腺癌细胞生长的抑制作用。

They significantly potentiated the cytotoxicity of cisplatin, but did not affect sensitivity to UVC.

它们的毒性大大强化铂，但并未影响到控灵敏度。

HEL has shown potentiating effect on cisplatin- induced cytotoxicity to cancer cells.

化合物HEL能强化顺铂对肿瘤细胞的细胞毒性。

Objective: The purpose of this study was to determine whether potentiating induction of apoptosis in cervical cancer cell line SiHa lacking full-length FHIT transcripts and endogenous FHIT protein by cisplatin via introduction of extopic FHIT gene. Meanwhile, to investigate if the apoptosis of the SiHa cells is induced by FHIT gene.

目的 验证外源性脆性组氨酸三联体抑癌基因的导入是否诱导宫颈癌SiHa细胞凋亡，观察FHIT导入与顺铂联合应用诱导宫颈癌SiHa细胞凋亡的作用是否有协同效应，为联合基因治疗和化疗药物治疗人宫颈癌提供实验依据。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐