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Multiple genetic changes have been found in ESCC,but little is known about major oncogenes and tumor suppressor genes involved in this disease.To surveying chromosome imbalances in this disease,we analyzed statistically high-frequency chromosomal changes of ESCC from the previous studies by multicolour fluorescence in situ hybridization and comparative genomic hybridization.

为鉴定与食管癌关系密切的基因，本研究从染色体畸变的角度出发，在实验室前期工作及相关文献的基础上，统计分析食管癌染色体畸变谱，发现3、5、8号染色体重排及着丝粒断裂再重组可能是最常见的结构改变，3q、8q增益是最常见的数目异常。

Here we used an in vivo assay to characterize different DNA polymerases and to understand their roles in simple end joining and chromosomal rearrangement in Saccharomyces cerevisiae.

在这篇研究我们在酵母菌系统中使用生体内分析方式来探讨不同的DNA聚合酶在简单末端连结与染色体重组中所扮演的角色。

Genetic changes by chromosomal rearrangements provide the variation among species and lead to natural selection during the process of evolution.

在物种演化的过程当中，可能因为基因序列的重新排列而造成个体间不同的差异产生，进而推动了物种天择。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。