查询词典 chromatin

RESULTS: Confocal microscopic evaluation of FITC-labeled TUNEL positive cells revealed nuclei with morphologic characteristics of apoptosis, consisting of typical crescent-shaped chromatin margination, nuclear fragmentation and formation of numerous micronuclei, especially in apoptosis of HCC-9204 cell line induced by adriamycin.

采用德国宝灵曼公司生产的原位末端标记试剂盒对福尔马林固定、石蜡包埋的肝组织和培养肝癌细胞进行TUNEL染色，激光共聚焦显微镜观察肝细胞凋亡的形态特征。

The apoptotic effects of LPS are detected by various skills such as fluorescence staining, TUNEL reaction, DNA agarose gel electrophoresis, electron microscopy and fluorescence activated cell sorting. Our results demonstrated that fish lymphocytes would be apoptotic under different LPS concentrations(above 10μg/ml) and different time(above 6h) inducing, which is characterized by condensation and margination of chromatin, the formation of apoptotic bodies.

结果显示，在10μg/ml以上浓度的内毒素作用18后或以100μg/ml浓度的LPS作用6h以上，淋巴细胞即可出现明显的凋亡形态学变化，表现为染色质凝集和周边化，核断裂，形成凋亡小体，DNA发生特异降解产生典型的"梯状"电泳图谱，呈现TUNEL阳性标记等，并通过流式细胞术证实这种凋亡具有时问和剂量的依赖性。

In light and electronic microscopy, they appeared cell shrinkage, cell density increasing and eosinophilic, aggregation of cytoplasmic organelles, nucleolus fragmentation, and chromatin margination, condensation, and fragmentation. Those changes could be detected by TUNEL method.

在光镜和电镜下癌细胞凋亡表现为细胞体积缩小，胞浆浓缩嗜酸性，胞浆出泡、细胞器缩小或减少，核仁松解，染色质聚集、靠边、浓聚、断裂，在TUNEL法检测凋亡癌细胞时也可观察到相应的形态特点。

The bulk of cells in the positive control group were dead.2 Treated with different dosages of DMF for 24h, it can be observed that green,nuclear margination and chromatin condensation were distinct in cells exposed to DMF.

研究结果 1。二甲基甲酰胺致人肝细胞凋亡形态学观察： 1不同剂量DMF染毒12h后，AO／EB染色可见阴性对照组无明显凋亡细胞，50mmol／L剂量组开始出现细胞形态接近正常，胞质为亮绿色，核出现固缩呈圆珠状，与正常细胞比较核质比变大的细胞。

The ultrastructural changes of the embryos cell in group Ⅳ were observed by transmission electronmicroscope,which showed condensation of the nuclear chromatin with margination,mitochondria swelling.etc.

照射30 min组小鼠胚胎细胞电镜检查发现染色质浓缩边集、线粒体肿胀等超微结构变化。

And the repression of NO-induced cell death with Ppbi-1 overexpression in transgenic lines was apparent even at SNP concentrations up to 1mM.In addition work,we found that most of suspension cells treated with 0.5mM SNP can be stained by Sytox green,some PCD morphologic characteristics such as chromatin condensation and margination can be observed.DNA Ladder was also detected with these cells.As to the control and the cell treated with 0.5mMSNP+20μM Est,the above-mentioned characteristics can\'t be detected.

对0.5mM SNP和0.5mM SNP+20μM Est处理的飞廉转基因细胞培养三天后用特异性核染料sytox染色，0.5mMSNP单独处理的细胞大部分核被染色，而且细胞核出现了核凝聚、以及染色质边集等凋亡细胞的特征；提取细胞DNA电泳分析，观察到了DNA LADDER，这说明，该细胞可能已经发生凋亡，而Est诱导Ppbi-1基因表达的细胞均未出现这些凋亡特征。

Methylation is negative correlation with genetic transcription , and the mechanism is probably as follows : directly interfere the combination of specific transcripton and recognition site of each promoter ; mediated transcription inhibition by change the construction of chromatin; induced gene silencing by combination of methylation site and transcription inhibition. P16 gene is also called multiple tumor supresser gene , which is the best easily to methylate in the anti-oncogenes. P16 gene locates in 9p21 of mankind-chromatosome , and it's total length is 8.5kb .

甲基化与基因转录呈负相关，其机制可能是[3]：直接干扰特异的转录子和各自启动子识别位点的结合；通过改变染色质结构，介导转录抑制；甲基化DNA位点直接与转录抑制子结合，诱导基因沉默。p16基因又称为多肿瘤抑制基因( multiple tumor suppressor 1 ，MTS1) [4] ，是肺癌中最易发生甲基化的抑癌基因，该基因位于人类染色体9p21上，全长8.5kb ，由两个内含子和三个外显子组成。

Misdivision of translocation chromosome at anaphase Ⅰ and rye chromatin micronucleus at tetrad stage were observed.

在遗4212×遗4095的F2代中检测到一个具有中间偃麦草染色体小片段易位到小麦染色体端粒部分的小麦-中间偃麦草易位植株。

The occurence of cytomixis or intercellular migrating chromatin substance exists widely in the pollen mother cell...

花粉母细胞间染色质穿壁转移现象在高等植物中广泛存在，但就其产生的原因素有争议。

We demonstrate that both the IL-5 mRNA expression and IL-5 protein production were stimulated by TSA and NaBu treatments. Chromatin immunoprecipitation assays showed that treatments of TSA and NaBu caused hyperacetylation of histones H3 and H4 at the IL-5 gene promoter in Jurkat cells, which consequently promoted the exogenous luciferase activity driven by this promoter.

TSA和丁酸钠能促进IL-5基因的mRNA和蛋白的表达水平，并增强该基因启动子所介导的外源荧光素酶报告基因的活性，这一增强作用与两种抑制剂介导的IL-5基因启动子上组蛋白H3和H4的高乙酰化有关。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐