查询词典 cholic

Objective: To search for effective drug that can lower the concentration of cholic acid in the regurgitation bile.

目的：探索降低反流胆汁中胆酸浓度的有效国产药物。

So the cholic acids may be the ringleader in fetal mechanisms in ICP.

因此胆酸可能是ICP中导致胎儿及新生儿死亡的罪魁祸首。

24H treatment group compared with 24h model group: the density of light of HSP70 of the group increased and which of TGF-β〓, is not different with the model group; the density of the light the HSP70 of the Baicalin group increased and which of it the TGF-β〓, increased with the model group; the density of light of the Concha Margatitifera Usta is not different and which of TGF-β〓, increased with the model group; the density of light of the Cholic Acid group is not different and the density of light of it of TGF-β〓 increased with the model group; the density of light of the Hefang Group is not different and which of TGF-β〓 is not different than the model group.

合方治疗脑缺血12小时组缺血脑组织TGF-β1光密度值较缺血12小时模型组无显著性差异（p＞0.05）。本实验结果发现，与单纯缺血12小时、24小时大鼠相比，药物干预组缺血侧大脑皮层TGF-β1免疫反应明显增强，计算机辅助图像半定量分析两组间缺血侧大脑皮层TGF-β1免疫阳性细胞数差异非常显著。说明药物对局灶性脑缺血损伤可能有一定保护作用，其机制可能与诱导脑细胞TGF-β1合成增加有关。然而，药物调控TGF-β1表达，其促TGF-β1表达增强的机制可能是这样的：脑缺血时TGF-β1mRNA表达增加可能与缺氧诱导神经和胶质细胞刺激生长因子表达有关。

12H treatment group compared with 12h model group: the density of light of HSP70 of the Gardenoside group is not different and which of it of TGFβ〓 increased with the model group; the density of light of the HSP70 of the Baicalin group in not different and which of the TGF-β〓 is no different with the model group, the density of HSP70 of the Concha Margatitifera Usta is not different and which of TGFβ〓 increased than the model group; the density of the HSP70 of the Cholic Acid group is no different and the density of TGF-β〓 increased than the model; the density of the light of HSP70 of the Hefang Group increased and which of TGF-β〓 increased than the model group.

合方治疗脑缺血12小时组缺血脑组织TGF-β1光密度值较缺血12小时模型组明显升高（p＜0.01）。大鼠局灶性脑缺血24小时模型组缺血脑组织TGF-β1光密度值含量较正常组明显增高（p＜0.01）。珍珠母治疗脑缺血24小时组缺血脑组织TGF-β1光密度值较缺血24小时模型组明显升高（p＜0.01）。胆酸治疗脑缺血24小时组缺血脑组织TGF-β1光密度值较缺血24小时模型组明显升高（p＜0.01）。栀子苷治疗脑缺血24小时组缺血脑组织TGF-β1光密度值较缺血24小时模型组无显著性差异（p＞0.05）。黄芩苷治疗脑缺血24小时组缺血脑组织TGF-β1光密度值较缺血24小时模型组明显升高（p＜0.01）。

12H treatment group compared with 12h model group: the level of MCP-1 of the Gardenoside group decreased and MIP-1 is no different with the model group; the level of the MCP-1, MIP-1 of the Baicalin group are no different with the model group; the level of MCP-1, MIP-1 of the Concha Margatitifera Usta decreased than the model; the level of MCP-1 of the Cholic Acid group is no different and the level of MIP-1 decreased than the model; the level of MCP-1 of the Hefang Group decreased and the level of MIP-1 of it decreased than the model group.

合方治疗脑缺血24小时组缺血脑组织nNos光密度值较缺血24小时模型组明显降低（p＜0.01）。细胞的死亡分为坏死和凋亡两种方式，凋亡是细胞为避免对机体造成更大损伤而采取的一种程序性的死亡方式。珍珠母、胆酸、栀子苷、黄芩苷、合方治疗组较脑缺血24小时模型组可明显降低P53阳性表达，考虑药物抑制细胞凋亡可以起到对缺血脑组织的保护作用。

12H treatment group compared with 12h model group: the level of SOD, MDA of the Gardenoside group is no different with the model group; the level of the SOD of the Baical in group increase and the level of MDA is no different; the level of SOD of the Concha Margatitifera Usta is no different and the MDA of it decreased than the model; the level of SOD of the Cholic Acid group increased and the level of MDA decreased; the level of SOD of the Hefang Group increased and the level of MDA of it decreased than the model group.

考虑nNos可能只是参与缺血早期的神经毒性作用。到缺血24小时这一时程已经减低或耗竭。大鼠局灶性脑缺血12小时模型组缺血脑组织P53光密度值含量较正常组明显增高（p＜0.01）。珍珠母治疗脑缺血12小时组缺血脑组织P53光密度值较缺血12小时模型组明显降低。胆酸治疗脑缺血12小时组缺血脑组织P53光密度值较缺血12小时模型组明显降低（p＜0.05）。栀子苷治疗脑缺血12小时组缺血脑组织P53光密度值较缺血12小时模型组明显降低（p＜0.05）。

24H treatment group compared with 24h model group: the level of MCP-1 of the Gardenoside group decreased, but the level of MIP-1 of it is no different with the model group; the level of the MCP-1 of the Baicalin group increase and the level of MIP-1 of it all decreased; the level of MCP-1 and MIP-1 of the Concha Margatitifera Usta all decreased; the level of MCP-1 of the Cholic Acid group decreased and the level of MIP-1 is no different with the model group; the level of MCP-1 and MIP-lof the Hefang Group decreased than the model group.

在本实验中，脑缺血能够诱导P53蛋白表达，P53蛋白可能参与调控缺血后神经细胞延迟性死亡的病理生理过程，药物通过抑制细胞凋亡，从而发挥治疗作用。五、大鼠局灶性脑缺血12小时模型组缺血脑组织HSP70光密度值含量较正常组明显增高（p＜0.05）。珍珠母治疗脑缺血12小时组缺血脑组织HSP70光密度值较缺血12小时模型组无显著性差异（p＞0.05）。胆酸治疗脑缺血12小时组缺血脑组织HSP70光密度值较缺血12小时模型组无显著性差异（p＞0.05）。

12H treatment group compared with 12h model group: the density of light of nNos of the Gardenoside group decreased and P53 decreased with the model group; the density of light of the nNos of the Baicalin group decreased and which of the P53 is no different with the model group, the density of nNos of the Concha Margatitifera Usta decreased and which of P53 decreased than the model; the density of of nNos of the Cholic Acid group is no different and the density of P53 decreased than the model; the density of the light of nNos of the Hefang Group is no different and which of P53 decreased than the model group.

珍珠母治疗脑缺血24小时组缺血脑组织HSP70光密度值较缺血24小时模型组无显著性差异（p＞0.05）。胆酸治疗脑缺血24小时组缺血脑组织HSP70光密度值较缺血24小时模型组无显著性差异（p＞0.05）。栀子苷治疗脑缺血24小时组缺血脑组织HSP70光密度值较缺血24小时模型组明显增高（p＜0.01）。黄芩苷治疗脑缺血24小时组缺血脑组织HSP70光密度值较缺血24小时模型组明显增高（p＜0.01）。合方治疗脑缺血24小时组缺血脑组织HSP70光密度值较缺血24小时模型组无显著性差异（p＞0.05）。

The stone in the neck of gallbladder is one of the important factors contributing to cholecystalgia, which plays a significant role in the emergency cases of cholic diseases.

胆囊颈部结石是发生胆绞痛的重要原因之一，在胆病急诊中占有十分重要的地位。

Cholic acid and deoxycholic acid are main components of bile and have an important biological function in human body.

胆酸和脱氧胆酸是胆汁酸中的主要成分，是人体中重要的生物表面活性剂。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。