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Within carboxylic groups, the coordination properties of carbonyl were studied and tn SEM graphs of picolinic acid, meta-methyl benzoic acid and 2-chloro-benzoic acid systems, a large amount of chains like structures probably caused by crystal growth have been firstly observed.

首次在杯[4]芳烃下沿羟基引进亲电性的三乙氧基硅基异腈酸丙酯,并且根据能量传递与匹配的机理合成了五种新型以改性超分子为功能片段的强键型杂化材料,其中与铽能量传递与发射情况最为优异。

The synthetic conditions of 4,4 dimethyl 3 oxopentanenitrile prepared sequentially from acetone through pinacol , pinacol one and α chloro pinacol one were investigated.

对以丙酮为原料、先依次制得片呐醇、片呐酮、α氯代片呐酮、最后由α氯代片呐酮与NaCN反应制得 4,4 二甲基 3 氧戊腈最后两步的反应条件进行了研究。

In order to find new pyrazole leading compounds, 14 1--4-(pyrazol- 5-ylcarbony)semicarbazide devivatives were synthesized from 4-chloro-3-ethyl-1-methyl-5-pyrazole car-bonydrazide and substituted phenylisocyanate.

为了寻求新的吡唑先导化合物,用4-氯-1-甲基-3-乙基-5-吡唑甲酰肼与取代苯基异氰酸酯反应得到了14个新的1-吡唑酰基-4-芳基氨基脲类化合物。

A compound of formula wherein R1 is hydrogen, halo or methoxy; R2 is hydrogen, halo, methyl, ethyl or methoxy; R3 is carboxy, tetrazolyl, or -CONHSO2R where R is methyl, ethyl, phenyl, 2,5-dimethylisoxazolyl or trifluoromethyl; T is -CH2- or -SO2-; and ring A is 3-chlorophenyl, 4-chlorophenyl, 3-trifluoromethylphenyl, 3,4-dichlorophenyl, 3,4-difluorophenyl, 3-fluoro-4-chlorophenyl, 3-chloro-4-fluorophenyl or 2,3-dichloropyrid-5-yl; or a pharmaceutically acceptable salt or prodrug thereof, as well as pharmaceutical compositions containing them are described and claimed.

本发明涉及一种式化合物,其中R 1 是氢原子、卤素或甲氧基;R 2 是氢原子、卤素、甲基、乙基或甲氧基;R 3 是羧基、四唑基或-CONHSO 2 R 4 ,其中R 4 是甲基、乙基、苯基、2,5-二甲基异∴唑基或三氟甲基;T是-CH 2 -或-SO 2 -;环A是3-氯苯基、4-氯苯基、3-三氟甲基苯基、3,4-二氯苯基、3,4-二氟苯基、3-氟-4-氯苯基、3-氯-4-氟苯基或2,3-二氯吡啶-5-基;或其药用允许的盐或前药,还包括所阐述和要求权利的含有它们的药用组合物。

Correlation analysis of both chlorotic plants and plants staying green of the F3populations revealed that there was a significant positive correlation between yield index values and the physiological indices net photosyn- thetic rate, stomatal conductance, and chloro- phyll, as well as a significant negative correlation between yield index values and the physiological indi- ces intercellular CO2 concentration and malondial- dehyde.

相关性分析表明收获指标与生理指标,如净光合速率、气孔导度、叶绿素含量等呈显著正相关;而与细胞间CO2 浓度及丙二醛含量呈显著负相关。

In this study, new benzo[l,2,3]thiadiazole derivatives were designed according to relationship of structure and efficacy. The 9 novel compounds were synsthesized with following reactions. The chlorine atom in 2-chloro-3,5-dinitro-benzoic acid as beginning raw material was substituted by 2-methylpropane-2-thiol, esterified then with bromoethane, reduced by iron powder and cyclized to obtain ethyl benzo[l,2,3]thiadiazole-7 after diazonation reation.

本论文根据苯并噻二唑诱导剂的构效关系设计了新的苯并噻二唑的结构,并合成了9个未见文献报道的化合物,合成步骤如下:采用2-氯-3,5-二硝基苯甲酸为起始原料,苯环上的氯原子被叔丁基硫醇置换,羧酸由溴乙烷酯化,硝基由铁粉还原,随后经重氮化关环生成苯并[1,2,3]噻二唑-7-羧酸乙酯。

Tetraphenyl-1,2-ethanediol and a S-S bond type thermal iniferter, i.e., tetraethyl thiuram disulfide were used to consist of new reverse ATRP initiation systems TPED/FeCl3/PPh3 and TD/FeCl3/PPh3, respectively.

这比文献(Sawamoto et al, 1998)报道的由2-氯-2,4,4-三甲基戊二酸二甲酯(dimethyl 2-chloro-2,4,4-trimethylglutarate)/RuCl2(PPh3)/Al引发体系引发MMA聚合的方法制备α-H,ω-Cl-PMMA要简便。

Syntheses of Grignard precursor, N - tert -butyl-4-chloro-piperidine, were accomplished via transamination with a quaternary ammonium piperidone or via addition of methylmagnesium chloride to an iminium ion.

氏体合成, N-叔丁基-4-氯哌啶、出自同一个经转氨酶哌季铵盐或透过增设methylmagnesium亚胺离子的氯化物。

As the paper industry,important addition agents,3-chloro-2-hydroxypropyl trimethyl ammonium chloride was useful the activity intermediates.

3-氯-2-羟丙基三甲基氯化铵可作为造纸工业中的重要助剂,是有用的活性中间体。

In the process, 2, 4-difluoroaniline is used to carry out ammoniated reaction. Then through a series of similar reactions, the important intermediate of temafloxacin, which is called 7-chloro-6-fluoro-1-(2, 4-difluorophenyl)-1, 4-dihydro-4-oxo-3-quinoline acid, is gained.

与环丙沙星和二氟沙星类似,用2,4-二氟苯胺进行胺化反应,再进行一系列类似的反应,制得合成替马沙星的关键中间体7-氯-6-氟-1-(2,4-二氟苯基)-1,4-二氢-4-氧代喹啉-3-羧酸。

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