查询词典 changes

The expressions of VEGF mRNA in renal cortex in B and group C increased greatly compared with A group at 8th week(P.01), And the expression was decreased more in C group than that in B group at the 8th week;④The light microscopes results showed that no pathological changes in group A; pathological changes were much obvious in group B:glomerular capillary lumen tumbling,lumens blocked,mesangial region widened,basal lamina thicking,mesenterium base inceased,the volume of glomerulus become large,cell population increased,renal tubule vacuolization, renal interstitium was infiltrated by lots of lymphocyte and mononuclear macrophage; pathological changes in group C was light,only see glomerular capillary lumen lightly stegnosis,few lymphocyte infiltrating.

免疫组化结果显示第8周B组大鼠肾皮质VEGF蛋白含量较A组显著增加(P.01)，C组VEGF含量较B组有明显减少(P.01)，C组较A组表达量仍然增加(P.01)；③第8周B组肾皮质VEGF mRNA表达较A组有明显上调(P.01)，与B组相比，辛伐他汀可以明显减少C组肾皮质VEGF mRNA表达；④光学显微镜下A组肾小球毛细血管腔均匀一致，无狭窄，肾小管-间质无炎症细胞浸润。B组则病变较明显：大鼠肾小球毛细血管袢塌陷，管腔闭塞，系膜区增宽，基膜增厚和系膜基质增多，肾小球体积增大，出现玻璃样变；肾小管尤其是近区小管肿胀、变性、空泡形成，肾间质可见大量淋巴细胞和单核巨噬细胞浸润。C组病变较轻，可见肾小球毛细血管管腔轻度狭窄，肾小管-间质见少量淋巴细胞浸润。

Structural magnetic resonance imaging include lineal mesure, volume measure and volume rendered. They can detect the abnormal brain structure, especially the change of mesial temporal lobe in early onset of Alzheimer s disease. Recent studies more focused on functional imaging which can find the functional changes in brain. Prior to structural changes, functional changes happen, so it can reflect the sutile pathological process in Alzheimer s disease.

磁共振成像结构影像学主要介绍了磁共振成像线性和面积测量、磁共振成像体积测量和磁共振容积再现三方面，其研究热点主要集中于阿尔茨海默病患者异常脑结构的分布，以及特征性结构内侧颞叶，尤其是海马，杏仁核，以及内嗅皮质在结构在阿尔茨海默病早期诊断治疗中的作用。

Methods The acute necrotizing pancreatitis model was made by retrograde injection of3.5%Sodium Taurocholic Acid into the rat's pancreatic duct.Through mirabilit for external application and qing yi decoction,the changes of serum endothelin,nitric oxide,amylase and the weight changes ofmirabilit for external application and the pathological changes of pancreas,lungs were observed.

应用牛磺胆酸钠逆行胰胆管穿刺注射造成大鼠急性坏死性胰腺炎（acute necrotizing pancreatitis，ANP）模型，通过芒硝外敷与清胰汤内服联合应用，观察大鼠血清内皮素（endothelin，ET）、一氧化氮（nitric oxide，NO）、血清淀粉酶（amylase，AMY）的变化及芒硝外敷前后自身重量的变化和胰腺、肺脏的病理变化。

Meanwhile, the three-dimensional mechanical characteristics of calcium thenardite salt rock take great changes after a period of solution pervasion actions. The compression strength of calcium thenardite rock salt changes from 46.53MPa to 11.42MPa after 49h solution pervasion with 2.0MPa confining pressure. Accordingly, the elastic modulus changes from 43.700MPa to 0.834MPa.

由于溶解渗透使得矿物组成及其结构的变化，钙芒硝盐岩在溶解渗透前后三轴力学特性差异也很大，在2.0MPa围压的作用条件下，溶解渗透49h之后，钙芒硝盐岩的强度由未溶解渗透时的46.53MPa，降低为溶解渗透后的11.42MPa；与此同时，弹性模量也由43.700MPa降低为0.834MPa。

Reactive oxygen species causing DNA oxidative damage comes from two kinds of ways:one is from cellular normal physiological metabolism;the other is from outer environment.Redox-sensitive green fluorescent protein was expressed in Saccharomyces cerevisiae.Recombinant cells were evaluated in monitoring the changes in the redox state of living cells when challenged with toxicologically relevant metal ions NaAsO_2 or Pb(NO_3)_2 by measuring emission intensity at 510 nm with a Hitachi F6500 fluorescence spectrophotometer,roGFP expressed in yeast responded not only to typical membrane-permeant oxidants H_2O_2 and reductants DTT,but also to toxicological metal ion-induced intracellular redox changes in a dose-dependent manner.Moreover,exposure of yeast cells to NaAsO_2 or Pb(NO_3)_2 at concentrations that induced redox changes reported by roGFP caused up to 2～3 fold increases in DNA mutation frequency.This mutagenic effect was largely caused by oxidative stress since blocking the production of hydryl radicals with thiourea significantly reduced the mutation rate as well as delayed the cell death.

本文将对氧化还原状态变化敏感的绿色荧光蛋白roGFP1-R12，在酵母细胞中实现了多拷贝强表达；荧光扫描经强氧化剂H_2O_2和还原剂DTT以及环境中重金属NaAsO_2或Pb(NO_3)_2处理后的酵母细胞悬液，测定510 nm处的荧光发射强度结果显示，表达的绿色荧光蛋白对氧化还原水平敏感，且在510 nm处的荧光强度与一定的重金属浓度呈正相关，即roGFP1-R12在510nm处的荧光发射值随重金属浓度的增高而增强，从而说明重金属对细胞的毒性在一定程度上很可能是通过破坏细胞内的氧化还原平衡发生作用；同时通过该绿色荧光蛋白对胞内氧化还原状态变化的响应情况可以来实时检测环境中的重金属；遗传学的点突变频率及致死率实验数据表明，重金属能导致菌体的点突变频率和致死率升高，且活性氧的清除剂巯基脲能明显降低这种点突变和致死率，说明由重金属引发的这种点突变和致死效应在很大程度上是依赖于重金属对细胞诱导产生的氧化胁迫。

Materials and methods: The lung preparation of 6 SARS death patient (died in 9,14,20,29,33,38d) and 6 macaque model (killed in 7,12,14,14, 32, 35d)were objects. Pathological changes, collagen fibers, lattice fibers, elastic fibers, collagen I and III in lungs and fine structure changes were studied by routine H.E dyeing, trigeminy dyeing, trinitrophenol- sirius red staining and polarization microscope, electron microscope and image analysis. Expression of Vimentin、 TGFβ_1、 TNF α、 IL-1β and MMP-2 were detected by immunohistochemistry.Results:1. Pathological changes of SARS death patient.

材料与方法：以6例SARS死亡患者(分别于发病后9、14、20、29、33、38d死亡)和6只猕猴实验模型(分别于染毒后7、12、14、14、32、35d活杀取材)肺标本为对象，应用H.E染色、三联染色、苦味酸-天狼猩红-偏振光法、电镜和图像分析等技术，对比性观察SARS肺组织病理变化和纤维化的病理过程、胶原纤维、网状纤维和弹力纤维的变化特点、Ⅰ型与Ⅲ型胶原纤维的数量和分布规律，旨在探讨SARS肺纤维化的病变经历过程及特点；利用免疫组织化学和形态计量学技术检测SARS死亡患者肺脏的Vimentin、TGFβ_1、TNFα、IL-1β和MMP-2等与炎症反应和纤维化相关活性因子，探讨其发病机制。

Results: in control group, there were no atherosclerotic changes on endarterium; in model group, there were obviously atherosclerotic changes on endarterium, in "National pits1573" 520、450、380 Alcohol group and 450 control Alcohol group, there were unconspicuously atherosclerotic changes on endarterium.

结果：空白对照组主动脉内膜未见粥样硬化改变；模型组主动脉内膜粥样硬化斑块形成，部分斑块病灶范围较大；45°对照酒组仅见少量散在脂质条纹；&国窖1573&52°、45°组，仅见轻度主动脉粥样硬化改变；38°组，主动脉壁见散在少量小范围脂质条纹。

We observed the changes of the proprioceptors in the partly injuried ACL and the xenogeneic graft/artificial graft being used to reconstructing the injuried ACL with gold chlorid staining method and laser copolymerization electron micrography method to observe the morphological changes of the neuromechanism in the ligament tissue,with RT-PCR method to evaluate the proportion and the regeneration of the nerve component and with HRP retrograde tracking technology and electrophysiologic study to judge the functional changes of the neuromechanism in the ligament tissue,respectively.

本研究分别制作兔ACL部分损伤动物模型、异种肌腱移植物重建损伤ACL动物模型和LARS人工韧带重建损伤ACL动物模型，分别于术后不同时间点对损伤ACL/移植物进行氯化金染色光学显微镜检查和PGP9.5免疫荧光染色后激光共聚焦电子显微镜检查观察韧带内神经结构形态学变化，用RT-PCR法检测韧带中GAP-43和PGP 9.5的mRNA表达情况以评价损伤ACL/移植物内神经成分比例及神经再生情况，通过HRP逆行追踪技术和电生理检查(包括体感诱发电位和腘绳肌肌电图)评价损伤ACL/移植物内神经结构的功能情况。

The execution of new curriculum makes Politics in Junior Middle School become lively, and students become enthusiastic in class, which changes the hollow moralisation before, changes speaking all the time and changes the situation that students only can study passively.

新课程的实施使初中思品课堂变得生动活泼，学生参与课堂活动热情高涨，改变了以往枯燥空洞的说教，改变了以往&一言堂&、&满堂灌&，改变了学生只能被动学习的状况。

Schizophrenic CSF can result in significant pathologically ultrastructural changes of neurons and cerebral capillaries of macaque' brain. CSF of patients with brain atrophy can produce more serious pathological changes than CSF of patients without that. Abnormal microvessel milieus may probably contribute the neuron pathological changes and play an important role in biological mechanism of schizophrenia.

（ 1 ）精神分裂症病人脑脊液可导致食蟹猴大脑神经元超微结构发生明显病理改变，脑结构异常者的影响更为明显和严重；（ 2 ）精神分裂症病人脑脊液可造成食蟹猴大脑毛细血管超微结构发生血管周围水肿和内皮细胞病变等病理改变；（ 3 ）微血管环境异常可能在精神分裂症病理机制中具有重要作用。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。